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Edward Thomas Ryan

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Edward Thomas Ryan
Born (1962-09-05) September 5, 1962 (age 62)
New York City
Alma materPrinceton University (A.B.)
Harvard University (M.D.)
Scientific career
InstitutionsMassachusetts General Hospital Harvard University
WebsiteLaboratory Webpage

Edward Thomas Ryan (born September 5, 1962) is an American microbiologist, immunologist, and physician at Harvard University and Massachusetts General Hospital. Ryan served as president of the American Society of Tropical Medicine and Hygiene from 2009 to 2010. Ryan is Professor of Immunology and Infectious Diseases at the Harvard T.H. Chan School of Public Health, Professor of Medicine at Harvard Medical School, and Director of Global Infectious Diseases at the Massachusetts General Hospital. Ryan's research and clinical focus has been on infectious diseases associated with residing in, immigrating from, or traveling through resource-limited areas. Ryan is a Fellow of the American Society of Microbiology, the American Society of Tropical Medicine and Hygiene, the American College of Physicians, and the Infectious Diseases Society of America.

Ryan's investigative work has focused on tropical, emerging and global infectious diseases, especially understanding host-pathogen interactions, and relating that knowledge to the discovery, development, and implementation of advanced diagnostics and vaccines. Particular areas of focus include cholera, typhoid, shigella, COVID-19 and the transmission of infectious diseases by humans crossing international borders.

Career

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Early career and training

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Ryan was born in New York City and educated at the Horace Mann School. He received his bachelor's degree in biochemical sciences at Princeton University. He received a doctorate in medicine from Harvard University. He performed medical residency and fellowship training in infectious diseases at the Massachusetts General Hospital. Ryan received additional training at the London School of Hygiene and Tropical Medicine and the International Center for Diarrhoeal Disease Research (ICDDRB) in Dhaka, Bangladesh. Ryan was also an overseas fellow of the Center for the Study of the Society and Medicine, Columbia University College of Physicians and Surgeons. Following his training, Ryan joined the faculty of Harvard University and the staff of the Massachusetts General Hospital. He was appointed Professor at Harvard University in April, 2012. Ryan resides in Wellesley, Massachusetts.

Cholera

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Together with Dr. Stephen Calderwood, Dr. Jason Harris, Dr. Regina LaRocque, Dr. Daniel Leung, Dr. Richelle Charles and colleagues at Harvard, and Dr. Firdausi Qadri and colleagues at the ICDDRB, Ryan has focused on advancing understanding of host-pathogen and immune responses during cholera, a human-restricted infection that largely afflicts impoverished individuals in resource-limited areas of the world. Ryan's investigative work is supported by the U.S. National Institutes of Health. Significant contributions include the finding that contrary to the previously established paradigm, cholera induces a pro-inflammatory response in afflicted humans, and that this response correlates with magnitude and duration of immunity against cholera.[1][2][3] Ryan has particularly focused on analyzing immune responses against the polysaccharide coating of the Vibrio cholerae organism, the O-specific polysaccharide (OSP), working with Dr. Paul Kovac of the National Institutes of Health.[4][5] Immune responses to OSP mediate protection against cholera in humans,[3] and Ryan et al have shown that this protection is associated with the ability of antibodies targeting V. cholerae OSP to inhibit the normally highly mobile bacteria from swimming inside the intestinal lumen.[6][7] This work has informed advanced vaccine development.[8][9][10] Ryan has been awarded a MERIT Award from the NIH in support of these efforts.

Typhoid

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Ryan's efforts in typhoid have largely focused on using high throughput analyses to characterize both pathogen responses during typhoid fever, including bacterial gene expression in infected humans, and human immune responses to bacterial infection.[11][12][13] This collaborative work with Charles and Qadri has identified a biomarker of chronic carriage of the bacillus that causes typhoid fever (YncE; STY1479),[14] and included the first transcriptional (gene expression) analysis of a bacterial pathogen directly in the bloodstream of an infected human;[15][16] work that was performed in humans with typhoid and paratyphoid fever in Bangladesh. This work has informed diagnostic assay development.[17][18]

Shigella

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Ryan's efforts on shigellosis have focused on vaccine development and host-pathogen interactions.[19][20] In 2006, Ryan showed that administration of antibiotics to children with shigellosis in Bangladesh did not increase toxin production by the bacterium.[20] This finding supports targeted antimicrobial treatment of humans with shigellosis. Such treatment is usually contraindicated in humans infected with Shiga-toxin expressing E. coli infection (STEC/EHEC: enterohemorrhagic E. coli, Verotoxin-producing Escherichia coli), in whom such treatment substantially increasing the risk of renal failure.[21]

Global TravEpiNet

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Ryan co-directs the Global TravEpiNet (GTEN) consortium and program with Dr. Regina LaRocque. GTEN's focus has been to advance the health of U.S. residents who cross international borders. The GTEN network and its support tools were developed with support from the Centers for Disease Control and Prevention with the goal of lessening illness relating to crossing international borders and the likelihood of disease importation into home communities. This program has included the development of a number of public health programs and resources, including web tools that provide up-to-date recommendations on health interventions and risks; these resources are maintained within the Heading Home Healthy Program.[22]

COVID-19

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When the COVID-19 pandemic began, Ryan pivoted his focus to working collaboratively on COVID-19. Efforts included development of an EUA (Expanded Access Authorized) laboratory-based PCR test, development of serologic assays for SARS-CoV-2 (the virus that causes COVID-19), analysis of persistence and decay of human antibody responses in COVID-19 patients, assessment of test performance characteristics of available serological and PCR assays against SARS-CoV-2, development of ultrasensitive antigen and antibody detection systems for SARS-CoV-2, assessment of immunologic cross-reactivity of SARS-CoV-2 with other coronaviridae, assessment of immune responses to SARS-CoV-2 in children, assessment of COVID-19 in Bangladesh, analysis of antibody functionality and signature during SARS-CoV-2 infection in relationship to mortality outcome, comparison of immune responses following vaccination to those induced by SARS-CoV-2 infection, assessment of plasma viral load with severity and mortality, and evaluation of the genomic epidemiology of SARS-CoV-2 in the Boston area. The detailed genomic epidemiology research identified that SARS-CoV-2 was imported repeatedly into the Boston area in early 2020 through international and domestic travel, and that a single superspreading event in Boston was genetically linked to over 300,000 subsequent cases in multiple states and in at least 9 countries in Europe, Asia and Oceania.[23]

Clinical activities

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Ryan is a staff Physician and Pediatrician at the Massachusetts General Hospital. He is Board certified in both Internal Medicine and Infectious Diseases, and has expertise in global infectious diseases and tropical medicine, including clinical parasitology, virology, bacteriology and mycology. Ryan is the Director of Global Infectious Diseases at Massachusetts General Hospital, and in 2006 isolated a new bacterial species (Bartonella rochalimae) in the blood of a woman with fever and splenomegaly who had recently been in Peru. The bacterium was characterized with colleagues at the University of California at San Francisco and the Centers for Disease Control and Prevention.[24] Ryan served with the Massachusetts General Hospital field deployment team aboard the USNS Mercy hospital ship in Banda Aceh, Indonesia following the December 26, 2004 Indian Ocean earthquake and tsunami.[25][26]

Teaching

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Ryan teaches at Harvard College, Harvard Medical School and the Harvard School of Public Health. He trains post-doctoral fellows and students in his laboratory, as well as intern, resident, fellow and student clinicians-in-training at the Massachusetts General Hospital. He directs a Fogarty International Center Training program between the Massachusetts General Hospital and the ICDDRB in Bangladesh.

Service

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Ryan has served on advisory and review committees for the National Institutes of Health, the US Centers for Disease Control and Prevention, and the Institute of Medicine.

Publications

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Ryan has authored or co-authored over 300 publications, including over 200 in the peer-reviewed literature. He also has served in editorial capacities for PLoS Neglected Tropical Diseases, the CDC Yellow Book[27] (Health Information for International Travel), Microbes and Infections,[28] and is Senior Editor of Hunter’s Tropical Infectious Diseases.

References

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  1. ^ Karlsson, Elinor K.; Harris, Jason B.; Tabrizi, Shervin; Rahman, Atiqur; Shlyakhter, Ilya; Patterson, Nick; O'Dushlaine, Colm; Schaffner, Stephen F.; Gupta, Sameer (2013-07-03). "Natural Selection in a Bangladeshi Population from the Cholera-Endemic Ganges River Delta". Science Translational Medicine. 5 (192): 192ra86. doi:10.1126/scitranslmed.3006338. ISSN 1946-6234. OCLC 730088152. PMC 4367964. PMID 23825302.
  2. ^ Arifuzzaman, Mohammad; Rashu, Rasheduzzaman; Leung, Daniel T.; Hosen, M. Ismail; Bhuiyan, Taufiqur Rahman; Bhuiyan, M. Saruar; Rahman, Mohammad Arif; Khanam, Farhana; Saha, Amit (2012-08-01). "Antigen-Specific Memory T Cell Responses after Vaccination with an Oral Killed Cholera Vaccine in Bangladeshi Children and Comparison to Responses in Patients with Naturally Acquired Cholera". Clinical and Vaccine Immunology. 19 (8): 1304–1311. doi:10.1128/CVI.00196-12. ISSN 1556-6811. OCLC 1064928926. PMC 3416086. PMID 22739692.
  3. ^ a b Patel, Sweta M.; Rahman, Mohammad Arif; Mohasin, M.; Riyadh, M. Asrafuzzaman; Leung, Daniel T.; Alam, Mohammad Murshid; Chowdhury, Fahima; Khan, Ashraful I.; Weil, Ana A. (2012-06-01). "Memory B Cell Responses to Vibrio cholerae O1 Lipopolysaccharide Are Associated with Protection against Infection from Household Contacts of Patients with Cholera in Bangladesh". Clinical and Vaccine Immunology. 19 (6): 842–848. doi:10.1128/CVI.00037-12. PMC 3370438. PMID 22518009.
  4. ^ Johnson, Russell A.; Uddin, Taher; Aktar, Amena; Mohasin, M.; Alam, Mohammad Murshid; Chowdhury, Fahima; Harris, Jason B.; LaRocque, Regina C.; Kelly Bufano, Meagan (2012-11-01). "Comparison of Immune Responses to the O-Specific Polysaccharide and Lipopolysaccharide of Vibrio cholerae O1 in Bangladeshi Adult Patients with Cholera". Clinical and Vaccine Immunology. 19 (11): 1712–1721. doi:10.1128/CVI.00321-12. PMC 3491541. PMID 22993410.
  5. ^ Leung, Daniel T.; Uddin, Taher; Xu, Peng; Aktar, Amena; Johnson, Russell A.; Rahman, Mohammad Arif; Alam, Mohammad Murshid; Bufano, Meagan Kelly; Eckhoff, Grace (2013-06-01). "Immune Responses to the O-Specific Polysaccharide Antigen in Children Who Received a Killed Oral Cholera Vaccine Compared to Responses following Natural Cholera Infection in Bangladesh". Clinical and Vaccine Immunology. 20 (6): 780–788. doi:10.1128/CVI.00035-13. ISSN 1556-6811. PMC 3675980. PMID 23515016.
  6. ^ Charles, Richelle C.; Kelly, Meagan; Tam, Jenny M.; Akter, Aklima; Hossain, Motaher; Islam, Kamrul; Biswas, Rajib; Kamruzzaman, Mohammad; Chowdhury, Fahima; Khan, Ashraful I.; Leung, Daniel T. (2020-11-17). "Humans Surviving Cholera Develop Antibodies against Vibrio cholerae O-Specific Polysaccharide That Inhibit Pathogen Motility". mBio. 11 (6). doi:10.1128/mBio.02847-20. ISSN 2150-7511. PMC 7683404. PMID 33203761.
  7. ^ Kauffman, Robert C.; Adekunle, Oluwaseyi; Yu, Hanyi; Cho, Alice; Nyhoff, Lindsay E.; Kelly, Meagan; Harris, Jason B.; Bhuiyan, Taufiqur Rahman; Qadri, Firdausi; Calderwood, Stephen B.; Charles, Richelle C. (2021-04-20). "Impact of Immunoglobulin Isotype and Epitope on the Functional Properties of Vibrio cholerae O-Specific Polysaccharide-Specific Monoclonal Antibodies". mBio. 12 (2). doi:10.1128/mBio.03679-20. ISSN 2150-7511. PMC 8092325. PMID 33879588.
  8. ^ Xu, Peng; Alam, Mohammad Murshid; Kalsy, Anuj; Charles, Richelle C.; Calderwood, Stephen B.; Qadri, Firdausi; Ryan, Edward T.; Kováč, Pavol (2011-10-19). "A Simple, Direct Conjugation of Bacterial O-SP–Core Antigens to Proteins: Development of Cholera Conjugate Vaccines". Bioconjugate Chemistry. 22 (10): 2179–2185. doi:10.1021/bc2001984. ISSN 1043-1802. OCLC 499596220. PMC 3197769. PMID 21899371.
  9. ^ Alam, Mohammad Murshid; Bufano, Megan Kelly; Xu, Peng; Kalsy, Anuj; Yu, Y.; Freeman, Y. Wu; Sultana, Tania; Rashu, Md. Rasheduzzaman; Desai, Ishaan (2014-02-06). "Evaluation in Mice of a Conjugate Vaccine for Cholera Made from Vibrio cholerae O1 (Ogawa) O-Specific Polysaccharide". PLOS Neglected Tropical Diseases. 8 (2): e2683. doi:10.1371/journal.pntd.0002683. ISSN 1935-2727. OCLC 1052652955. PMC 3916310. PMID 24516685.
  10. ^ Sayeed, Md. Abu; Bufano, Meagan Kelly; Xu, Peng; Eckhoff, Grace; Charles, Richelle C.; Alam, Mohammad Murshid; Sultana, Tania; Rashu, Md. Rasheduzzaman; Berger, Amanda (2015-07-08). "A Cholera Conjugate Vaccine Containing O-specific Polysaccharide (OSP) of V. cholerae O1 Inaba and Recombinant Fragment of Tetanus Toxin Heavy Chain (OSP:rTTHc) Induces Serum, Memory and Lamina Proprial Responses against OSP and Is Protective in Mice". PLOS Neglected Tropical Diseases. 9 (7): e0003881. doi:10.1371/journal.pntd.0003881. PMC 4495926. PMID 26154421.
  11. ^ Harris, Jason B.; Baresch-Bernal, Andrea; Rollins, Sean M.; Alam, Ashfaqul; LaRocque, Regina C.; Bikowski, Margaret; Peppercorn, Amanda F.; Handfield, Martin; Hillman, Jeffery D. (2006-09-01). "Identification of in vivo-induced bacterial protein antigens during human infection with Salmonella enterica serovar Typhi". Infection and Immunity. 74 (9): 5161–5168. doi:10.1128/IAI.00488-06. ISSN 0019-9567. OCLC 231008590. PMC 1594849. PMID 16926408.
  12. ^ Charles, Richelle C.; Sheikh, Alaullah; Krastins, Bryan; Harris, Jason B.; Bhuiyan, M. Saruar; LaRocque, Regina C.; Logvinenko, Tanya; Sarracino, David A.; Kudva, Indira T. (2010-08-01). "Characterization of Anti-Salmonella enterica Serotype Typhi Antibody Responses in Bacteremic Bangladeshi Patients by an Immunoaffinity Proteomics-Based Technology". Clinical and Vaccine Immunology. 17 (8): 1188–1195. doi:10.1128/CVI.00104-10. OCLC 1064928926. PMC 2916242. PMID 20573880.
  13. ^ Sheikh, Alaullah; Khanam, Farhana; Sayeed, Md. Abu; Rahman, Taibur; Pacek, Marcin; Hu, Yanhui; Rollins, Andrea; Bhuiyan, Md. Saruar; Rollins, Sean (2011-06-07). "Interferon-γ and Proliferation Responses to Salmonella enterica Serotype Typhi Proteins in Patients with S. Typhi Bacteremia in Dhaka, Bangladesh". PLOS Neglected Tropical Diseases. 5 (6): e1193. doi:10.1371/journal.pntd.0001193. PMC 3110156. PMID 21666798.
  14. ^ Charles, Richelle C.; Sultana, Tania; Alam, Mohammad Murshid; Yu, Yanan; Wu-Freeman, Ying; Bufano, Meagan Kelly; Rollins, Sean M.; Tsai, Lillian; Harris, Jason B. (2013-08-01). "Identification of Immunogenic Salmonella enterica Serotype Typhi Antigens Expressed in Chronic Biliary Carriers of S. Typhi in Kathmandu, Nepal". PLOS Neglected Tropical Diseases. 7 (8): e2335. doi:10.1371/journal.pntd.0002335. PMC 3731212. PMID 23936575.
  15. ^ Sheikh, Alaullah; Charles, Richelle C.; Rollins, Sean M.; Harris, Jason B.; Bhuiyan, Md. Saruar; Khanam, Farhana; Bukka, Archana; Kalsy, Anuj; Porwollik, Steffen (2010-12-07). "Analysis of Salmonella enterica Serotype Paratyphi A Gene Expression in the Blood of Bacteremic Patients in Bangladesh". PLOS Neglected Tropical Diseases. 4 (12): e908. doi:10.1371/journal.pntd.0000908. PMC 2998432. PMID 21151879.
  16. ^ Sheikh, Alaullah; Charles, Richelle C.; Sharmeen, Nusrat; Rollins, Sean M.; Harris, Jason B.; Bhuiyan, Md. Saruar; Arifuzzaman, Mohammad; Khanam, Farhana; Bukka, Archana (2011-12-13). "In Vivo Expression of Salmonella enterica Serotype Typhi Genes in the Blood of Patients with Typhoid Fever in Bangladesh". PLOS Neglected Tropical Diseases. 5 (12): e1419. doi:10.1371/journal.pntd.0001419. PMC 3236720. PMID 22180799.
  17. ^ Khanam, Farhana; Sheikh, Alaullah; Sayeed, Md. Abu; Bhuiyan, Md. Saruar; Choudhury, Feroza Kaneez; Salma, Umme; Pervin, Shahnaz; Sultana, Tania; Ahmed, Dilruba (2013-07-11). "Evaluation of a Typhoid/Paratyphoid Diagnostic Assay (TPTest) Detecting Anti-Salmonella IgA in Secretions of Peripheral Blood Lymphocytes in Patients in Dhaka, Bangladesh". PLOS Neglected Tropical Diseases. 7 (7): e2316. doi:10.1371/journal.pntd.0002316. PMC 3708850. PMID 23951368.
  18. ^ Charles, Richelle C.; Liang, Li; Khanam, Farhana; Sayeed, M. Abu; Hung, Chris; Leung, Daniel T.; Baker, Stephen; Ludwig, Albrecht; Harris, Jason B. (2014-03-01). "Immunoproteomic Analysis of Antibody in Lymphocyte Supernatant in Patients with Typhoid Fever in Bangladesh". Clinical and Vaccine Immunology. 21 (3): 280–285. doi:10.1128/CVI.00661-13. PMC 3957676. PMID 24371257.
  19. ^ Gaston, J. S. Hill; Inman, Robert D.; Ryan, Edward T.; Venkatesan, Malabi M.; Barry, Eileen M.; Hale, Thomas L.; Bourgeois, A. Louis; Walker, Richard I. (2009-09-04). "Vaccination of children in low-resource countries against Shigella is unlikely to present an undue risk of reactive arthritis". Vaccine. 27 (40): 5432–5434. doi:10.1016/j.vaccine.2009.06.107. ISSN 1873-2518. OCLC 1033745520. PMID 19643213.
  20. ^ a b Bennish, Michael L.; Khan, Wasif A.; Begum, Monira; Bridges, Emily A.; Ahmed, Sabeena; Saha, Debasish; Salam, Mohammad A.; Acheson, David; Ryan, Edward T. (2006-02-01). "Low risk of hemolytic uremic syndrome after early effective antimicrobial therapy for Shigella dysenteriae type 1 infection in Bangladesh". Clinical Infectious Diseases. 42 (3): 356–362. doi:10.1086/499236. ISSN 1537-6591. OCLC 237361199. PMID 16392080.
  21. ^ Wong, Craig S.; Jelacic, Srdjan; Habeeb, Rebecca L.; Watkins, Sandra L.; Tarr, Phillip I. (2000-06-29). "The Risk of the Hemolytic-uremic Syndrome After Antibiotic Treatment of Escherichia coli O157:H7 Infections". The New England Journal of Medicine. 342 (26): 1930–1936. doi:10.1056/NEJM200006293422601. ISSN 0028-4793. OCLC 783824088. PMC 3659814. PMID 10874060.
  22. ^ "Home - Heading Home Healthy - Helping travelers stay healthy when they are returning home to visit friends and relatives". www.headinghomehealthy.org. Retrieved 2016-02-04.
  23. ^ Lemieux, Jacob E.; Siddle, Katherine J.; Shaw, Bennett M.; Loreth, Christine; Schaffner, Stephen F.; Gladden-Young, Adrianne; Adams, Gordon; Fink, Timelia; Tomkins-Tinch, Christopher H.; Krasilnikova, Lydia A.; DeRuff, Katherine C. (2021-02-05). "Phylogenetic analysis of SARS-CoV-2 in Boston highlights the impact of superspreading events". Science. 371 (6529). doi:10.1126/science.abe3261. ISSN 1095-9203. PMC 7857412. PMID 33303686.
  24. ^ Eremeeva, Marina E.; Gerns, Helen L.; Lydy, Shari L.; Goo, Jeanna S.; Ryan, Edward T.; Mathew, Smitha S.; Ferraro, Mary Jane; Holden, Judith M.; Nicholson, William L. (2007-06-07). "Bacteremia, fever, and splenomegaly caused by a newly recognized bartonella species". The New England Journal of Medicine. 356 (23): 2381–2387. doi:10.1056/NEJMoa065987. ISSN 1533-4406. OCLC 474758153. PMID 17554119.
  25. ^ Kao, Ann Y.; Munandar, Rus; Ferrara, Stephen L.; Systrom, David M.; Sheridan, Robert L.; Cash, Sydney S.; Ryan, Edward T. (2005-06-23). "Case records of the Massachusetts General Hospital. Case 19-2005. A 17-year-old girl with respiratory distress and hemiparesis after surviving a tsunami". The New England Journal of Medicine. 352 (25): 2628–2636. doi:10.1056/NEJMcpc059015. PMID 15972870.
  26. ^ McDaniel, Bill (2014). Faces of the Tsunami. CreateSpace Publishing. ISBN 978-1500172565.
  27. ^ "2016 Yellow Book Home | Travelers' Health | CDC". wwwnc.cdc.gov. Retrieved 2019-02-07.
  28. ^ D.M. Ojcius (ed.). "Microbes and Infection". Microbes and Infection. Elsevier. ISSN 1286-4579. OCLC 177511751.
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