EF-1502

EF-1502
Names
	IUPAC name 4-[4,4-bis(3-methylthiophen-2-yl)but-3-enyl-methylamino]-4,5,6,7-tetrahydro-1,2-benzoxazol-3-one
Identifiers
CAS Number	684645-54-3 ;
3D model (JSmol)	Interactive image;
ChEMBL	ChEMBL1773934;
ChemSpider	9375888.html : 9375888;
PubChem CID	11200819;
	InChI InChI=1S/C22H26N2O2S2/c1-14-9-12-27-20(14)16(21-15(2)10-13-28-21)6-5-11-24(3)17-7-4-8-18-19(17)22(25)23-26-18/h6,9-10,12-13,17H,4-5,7-8,11H2,1-3H3,(H,23,25) Key: CUESOMOCKVRNIW-UHFFFAOYSA-N;
	SMILES CC1=C(SC=C1)C(=CCCN(C)C2CCCC3=C2C(=O)NO3)C4=C(C=CS4)C;
Properties
Chemical formula	C22H26N2O2S2
Molar mass	414.58 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

EF-1502 is a GABA reuptake inhibitor. It could potentially be used to treat seizures.

Mechanism of action

Tests in mice have shown that this compound possesses and anticonvulsant effect due to its GABA reuptake inhibiting properties.^[3]^[4]

^ Madsen, Karsten K.; White, H. Steve; Schousboe, Arne (March 2010). "Neuronal and non-neuronal GABA transporters as targets for antiepileptic drugs". Pharmacology & Therapeutics. 125 (3): 394–401. doi:10.1016/j.pharmthera.2009.11.007. ISSN 1879-016X. PMID 20026354.
^ Schousboe, Arne; Larsson, Orla M.; Sarup, Alan; White, H. Steve (2004-10-01). "Role of the betaine/GABA transporter (BGT-1/GAT2) for the control of epilepsy". European Journal of Pharmacology. 500 (1–3): 281–287. doi:10.1016/j.ejphar.2004.07.032. ISSN 0014-2999. PMID 15464040.
^ Madsen, Karsten K.; Hansen, Gert H.; Danielsen, E. Michael; Schousboe, Arne (February 2015). "The subcellular localization of GABA transporters and its implication for seizure management". Neurochemical Research. 40 (2): 410–419. doi:10.1007/s11064-014-1494-9. ISSN 1573-6903. PMID 25519681.
^ Schousboe, Arne; Sarup, Alan; Larsson, Orla M.; White, H. Steve (2004-10-15). "GABA transporters as drug targets for modulation of GABAergic activity". Biochemical Pharmacology. 68 (8): 1557–1563. doi:10.1016/j.bcp.2004.06.041. ISSN 0006-2952. PMID 15451399.