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DCHS2

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DCHS2
Identifiers
AliasesDCHS2, CDH27, CDHJ, CDHR7, PCDH23, PCDHJ, dachsous cadherin-related 2
External IDsOMIM: 612486; HomoloGene: 130686; GeneCards: DCHS2; OMA:DCHS2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001142552
NM_001142553
NM_017639
NM_199348
NM_001358235

n/a

RefSeq (protein)

NP_001136024
NP_001345164

n/a

Location (UCSC)Chr 4: 154.23 – 154.49 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Protein dachsous homolog 2, also known as protocadherin-23 (PCDH23) or cadherin-27 (CDH27), is a protein that in humans is encoded by the DCHS2 gene.[3][4]

DCHS2 has been implicated in the nose angle (how much a nose is upturned).[5] As well as facial genetics [6][7]

References

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  1. ^ a b c ENSG00000284227 GRCh38: Ensembl release 89: ENSG00000197410, ENSG00000284227Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Entrez Gene: dachsous 2 (Drosophila)".
  4. ^ Hoeng JC, Ivanov NV, Hodor P, Xia M, Wei N, Blevins R, et al. (March 2004). "Identification of new human cadherin genes using a combination of protein motif search and gene finding methods". Journal of Molecular Biology. 337 (2): 307–317. doi:10.1016/j.jmb.2004.01.026. PMID 15003449.
  5. ^ Adhikari K, Fuentes-Guajardo M, Quinto-Sánchez M, Mendoza-Revilla J, Camilo Chacón-Duque J, Acuña-Alonzo V, et al. (May 2016). "A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation". Nature Communications. 7: 11616. Bibcode:2016NatCo...711616A. doi:10.1038/ncomms11616. PMC 4874031. PMID 27193062.
  6. ^ Richmond S, Howe LJ, Lewis S, Stergiakouli E, Zhurov A (2018). "Facial Genetics: A Brief Overview". Frontiers in Genetics. 9: 462. doi:10.3389/fgene.2018.00462. PMC 6198798. PMID 30386375.
  7. ^ Firger J (19 May 2016). "Your nose--Big or small--is shaped by your DNA". Newsweek.

Further reading

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