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CLC (gene)

From Wikipedia, the free encyclopedia

CLC
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesCLC, GAL10, Gal-10, LGALS10, LGALS10A, LPPL_HUMAN, Charcot-Leyden crystal galectin, galectin-10
External IDsOMIM: 153310; HomoloGene: 130498; GeneCards: CLC; OMA:CLC - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001828

n/a

RefSeq (protein)

NP_001819

n/a

Location (UCSC)Chr 19: 39.73 – 39.74 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Galectin-10 is an enzyme that in humans is encoded by the CLC gene.[3][4]

Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene is a lysophospholipase expressed in eosinophils and basophils. It hydrolyzes lysophosphatidylcholine to glycerophosphocholine and a free fatty acid. This protein may possess carbohydrate or IgE-binding activities. It is both structurally and functionally related to the galectin family of beta-galactoside binding proteins. It may be associated with inflammation and some myeloid leukemias.[4]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000105205Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Mastrianni DM, Eddy RL, Rosenberg HF, Corrette SE, Shows TB, Tenen DG, Ackerman SJ (Jun 1992). "Localization of the human eosinophil Charcot-Leyden crystal protein (lysophospholipase) gene (CLC) to chromosome 19 and the human ribonuclease 2 (eosinophil-derived neurotoxin) and ribonuclease 3 (eosinophil cationic protein) genes (RNS2 and RNS3) to chromosome 14". Genomics. 13 (1): 240–2. doi:10.1016/0888-7543(92)90237-M. PMID 1577491.
  4. ^ a b "CLC Charcot-Leyden crystal galectin [ Homo sapiens (human) ]".

Further reading

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