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CAB39

From Wikipedia, the free encyclopedia
CAB39
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCAB39, MO25, CGI-66, calcium binding protein 39
External IDsOMIM: 612174; MGI: 107438; HomoloGene: 69212; GeneCards: CAB39; OMA:CAB39 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001130849
NM_001130850
NM_016289

NM_133781
NM_001355046
NM_001355047

RefSeq (protein)

NP_001124321
NP_001124322
NP_057373

NP_598542
NP_001341975
NP_001341976

Location (UCSC)Chr 2: 230.71 – 230.82 MbChr 1: 85.72 – 85.78 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Calcium-binding protein 39 is a protein that in humans is encoded by the CAB39 gene.[5]

The protein encoded by this gene associates with STK11 (Serine/Threonine Kinase 11) and STRAD (STE20-Related ADaptor protein).[6] CAB39 enhances formation of STK11/STRAD complexes and stimulates STK11 catalytic activity. CAB39 may function as a scaffolding component of the STK11/STRAD complex and regulates STK11 activity and cellular localization.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000135932Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036707Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: CAB39 calcium binding protein 39".
  6. ^ a b Boudeau J, Baas AF, Deak M, Morrice NA, Kieloch A, Schutkowski M, Prescott AR, Clevers HC, Alessi DR (October 2003). "MO25α/β interact with STRADα/β enhancing their ability to bind, activate and localize LKB1 in the cytoplasm". EMBO J. 22 (19): 5102–14. doi:10.1093/emboj/cdg490. PMC 204473. PMID 14517248.
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Further reading

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