Butamisole

Butamisole
Identifiers
	IUPAC name 2-Methyl-N-[3-(2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazol-6-yl)phenyl]propanamide;
CAS Number	54496-44-5;
PubChem CID	166572;
ChemSpider	145767;
ChEMBL	ChEMBL2110807;
CompTox Dashboard (EPA)	DTXSID8057770 ;
Chemical and physical data
Formula	C15H19N3OS
Molar mass	289.40 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(C)C(=O)NC1=CC=CC(=C1)C2CN3CCSC3=N2;
	InChI InChI=1S/C15H19N3OS/c1-10(2)14(19)16-12-5-3-4-11(8-12)13-9-18-6-7-20-15(18)17-13/h3-5,8,10,13H,6-7,9H2,1-2H3,(H,16,19); Key:YWDWYOALXURQPZ-UHFFFAOYSA-N;

Butamisole is a pharmaceutical drug used in veterinary medicine.^[1] It is an anthelmintic of the imidazothiazole class.^[2] In dogs it is used for the treatment of infections with whipworms such as Trichuris vulpis and with hookworm such as Ancylostoma caninum.^[3] It acts as a nicotinic acetylcholine receptor agonist that causes sustained muscle contraction in the parasite followed by depolarizing neuromuscular blockade which leads to paralysis.^[3]

References

^ B. T. Alford, G. T. Wang, T. R. Garces, R. B. Dougherty, R. E. Bradley (1979). "The efficacy and safety of injectable butamisole in dogs". Veterinary Medicine & Small Animal Clinician. 74 (4): 487–495. PMID 256371.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^ Martin, R.J. (1997). "Modes of action of anthelmintic drugs". The Veterinary Journal. 154 (1): 11–34. doi:10.1016/S1090-0233(05)80005-X. PMID 9265850.
^ ^a ^b "Butamisole". Inxight Drugs. National Center for Advancing Translational Sciences.

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