ASXL3

ASXL3
Identifiers
Aliases	ASXL3, BRPS, KIAA1713, additional sex combs like 3, transcriptional regulator, ASXL transcriptional regulator 3
External IDs	OMIM: 615115; MGI: 2685175; HomoloGene: 19371; GeneCards: ASXL3; OMA:ASXL3 - orthologs
Gene location (Human) Chr. Chromosome 18 (human) Band 18q12.1 Start 33,578,219 bp End 33,751,195 bp
Gene location (Mouse) Chr. Chromosome 18 (mouse) Band 18|18 A2 Start 22,477,303 bp End 22,663,284 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell secondary oocyte sperm testicle ganglionic eminence Brodmann area 23 middle temporal gyrus sural nerve endothelial cell ventricular zone Top expressed in superior cervical ganglion Rostral migratory stream hand trigeminal ganglion genital tubercle maxillary prominence otolith organ mandibular prominence utricle ganglionic eminence More reference expression data BioGPS n/a
Gene ontology Molecular function metal ion binding DNA binding chromatin binding peroxisome proliferator activated receptor binding Cellular component nucleus PR-DUB complex Biological process regulation of transcription, DNA-templated transcription, DNA-templated animal organ morphogenesis positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 80816 211961 Ensembl ENSG00000141431 ENSMUSG00000045215 UniProt Q9C0F0 Q8C4A5 RefSeq (mRNA) NM_030632 NM_001167777 RefSeq (protein) NP_085135 NP_001161249 Location (UCSC) Chr 18: 33.58 – 33.75 Mb Chr 18: 22.48 – 22.66 Mb PubMed search
Wikidata
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Putative Polycomb group protein ASXL3 is a protein that in humans is encoded by the ASXL3 gene.

See also

• Bainbridge–Ropers syndrome
• Polycomb-group proteins
• ASXL1
• ASXL2

Further reading

• Fisher CL, Randazzo F, Humphries RK, Brock HW (March 2006). "Characterization of Asxl1, a murine homolog of Additional sex combs, and analysis of the Asx-like gene family". Gene. 369: 109–18. doi:10.1016/j.gene.2005.10.033. PMID 16412590.
• Katoh M, Katoh M (June 2004). "Identification and characterization of ASXL3 gene in silico". International Journal of Oncology. 24 (6): 1617–22. PMID 15138607.