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ARFRP1

From Wikipedia, the free encyclopedia
ARFRP1
Identifiers
AliasesARFRP1, ARL18, ARP, Arp1, ADP ribosylation factor related protein 1
External IDsOMIM: 604699; MGI: 1923938; HomoloGene: 2425; GeneCards: ARFRP1; OMA:ARFRP1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001165991
NM_001165992
NM_001165995
NM_029702

RefSeq (protein)

NP_001159463
NP_001159464
NP_001159467
NP_083978

Location (UCSC)Chr 20: 63.7 – 63.71 MbChr 2: 181 – 181.01 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

ADP-ribosylation factor-related protein 1 is a protein that in humans is encoded by the ARFRP1 gene.[5][6]

Function

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The protein encoded by this gene is a membrane-associated GTP-ase and localizes to the plasma membrane. It is related to the ADP-ribosylation factor (ARF) and ARF-like (ARL) genes. The gene is located in a gene cluster that includes the a gene (M68) that is overexpressed in some tumors.[6]

Interactions

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ARFRP1 has been shown to interact with PSCD1.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000101246Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038671Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Schurmann A, Massmann S, Joost HG (Jan 1996). "ARP is a plasma membrane-associated Ras-related GTPase with remote similarity to the family of ADP-ribosylation factors". J Biol Chem. 270 (51): 30657–63. doi:10.1074/jbc.270.51.30657. PMID 8530503.
  6. ^ a b "Entrez Gene: ARFRP1 ADP-ribosylation factor related protein 1".
  7. ^ Schürmann A, Schmidt M, Asmus M, Bayer S, Fliegert F, Koling S, Massmann S, Schilf C, Subauste MC, Voss M, Jakobs KH, Joost HG (April 1999). "The ADP-ribosylation factor (ARF)-related GTPase ARF-related protein binds to the ARF-specific guanine nucleotide exchange factor cytohesin and inhibits the ARF-dependent activation of phospholipase D". J. Biol. Chem. 274 (14): 9744–51. doi:10.1074/jbc.274.14.9744. PMID 10092663.

Further reading

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