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3-hydroxyisobutyryl-CoA hydrolase

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3-hydroxyisobutyryl-CoA hydrolase
3-hydroxyisobutyryl-CoA hydrolase monomer, Human
Identifiers
EC no.3.1.2.4
CAS no.9025-88-1
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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PMCarticles
PubMedarticles
NCBIproteins

The enzyme 3-hydroxyisobutyryl-CoA hydrolase (EC 3.1.2.4) catalyzes the reaction

3-hydroxy-2-methylpropanoyl-CoA + H2O CoA + 3-hydroxy-2-methylpropanoate

This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. The systematic name is 3-hydroxy-2-methylpropanoyl-CoA hydrolase. Other names in common use include 3-hydroxy-isobutyryl CoA hydrolase, and HIB CoA deacylase. This enzyme participates in 3 metabolic pathways: valine, leucine and isoleucine degradation, β-alanine metabolism, and propanoate metabolism. 3-hydroxyisobutyryl-CoA hydrolase is encoded by HIBCH gene.[1]

References

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  1. ^ "OMIM Entry - * 610690 - 3-HYDROXYISOBUTYRYL-CoA HYDROLASE; HIBCH". www.omim.org. Retrieved 2017-11-20.
  • Rendina G, Coon MJ (March 1957). "Enzymatic hydrolysis of the coenzyme A thiol esters of β-hydroxypropionic and β-hydroxyisobutyric acids". The Journal of Biological Chemistry. 225 (1): 523–34. PMID 13457352.