Adenosylhomocysteinase
| S-adenosylhomocysteine hydrolase | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | AHCY | ||||||
| NCBI gene | 191 | ||||||
| HGNC | 343 | ||||||
| OMIM | 180960 | ||||||
| RefSeq | NM_000687 | ||||||
| UniProt | P23526 | ||||||
| Other data | |||||||
| EC number | 3.3.1.1 | ||||||
| Locus | Chr. 20 q11.22 | ||||||
| |||||||
Adenosylhomocysteinase (EC 3.3.1.1, S-adenosylhomocysteine synthase, S-adenosylhomocysteine hydrolase, adenosylhomocysteine hydrolase, S-adenosylhomocysteinase, SAHase, AdoHcyase) is an enzyme that converts S-adenosylhomocysteine to homocysteine and adenosine.[1][2] This enzyme catalyses the following chemical reaction
- S-adenosyl-L-homocysteine + H2O L-homocysteine + adenosine
The enzyme contains one tightly bound NAD+ per subunit.
References
- ^ de la Haba, G.; Cantoni, G.L. (1959). "The enzymatic synthesis of S-adenosyl-L-homocysteine from adenosine and homocysteine". J. Biol. Chem. 234: 603–608. PMID 13641268.
- ^ Palmer, J.L.; Abeles, R.H. (1979). "The mechanism of action of S-adenosylhomocysteinase". J. Biol. Chem. 254: 1217–1226. PMID 762125.
External links
- Adenosylhomocysteinase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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