Radiation Oncology/Online tools

Online Tools

Radiobiology

Linear Quadratic / BED / EQD Calculators:

• 2 Gray Equivalent Calculator (Kathmandu, Nepal)
  • Gives 2 Gy equivalent dose at different α/β.
• Site down: http://www.radiotherapy.com/calculate Radiotherapy Dose Calculator (radiotherapy.com) - BED, alpha-beta calculator (Java applet)
• RBApp - BED, EQD2, alpha-beta calculator (Web App, Android, BlackBerry)
• eLQ - linear quadratic calculator

Brachytherapy:

• See "calculation tools" at: Radiation_Oncology/Cervix/Brachytherapy#Equivalent_doses
  • e.g. HDR vs LDR BED calculations

Cancer: General

• Memorial Sloan Kettering Nomograms
• Cleveland Clinic Risk Calculators
• Adjuvant Online (account required)

Cancer: Site Specific

Bladder Cancer

• MSKCC Bladder Survival After Surgery

Breast Cancer

• Ipsilateral Breast Tumor Recurrence
  • Invasive Disease
    • IBTR!- https://www.tuftsmedicalcenter.org/ibtr/
      • 10-year prediction of ipsilateral breast cancer recurrence after BCS and axilla evaluation, with and without RT
      • 2010: PMID 20048188 -- "Validation of a Web-Based Predictive Nomogram for Ipsilateral Breast Tumor Recurrence After Breast Conserving Therapy." (Sanghani M, JCO)
    • IBR - http://research.nki.nl/ibr/ibr/index.html
      • 10-yr prediction of ipsilateral breast recurrence free probability for RT w/ or w/o boost.
      • 2011: PMID 21821304 -- "Nomogram to predict ipsilateral breast relapse based on pathology review from the EORTC 22881-10882 boost versus no boost trial." (van Werkhoven, RO)
  • DCIS
    • MSKCC DCIS Recurrence Calculator - http://nomograms.mskcc.org/Breast/DuctalCarcinomaInSituRecurrencePage.aspx
      • Estimates 5 and 10 yr risks of ipsilateral recurrence after lumpectomy and different adjuvant therapy choices (eg RT, endocrine therapy)
      • 2010: PMID 20625132 -- "Nomogram for predicting the risk of local recurrence after breast-conserving surgery for ductal carcinoma in situ." (Rudloff, JCO)

• Risk of Positive Nodes
  • Probability of Finding Additional Positive Nodes AFTER Sentinel Lymph Node Biopsy (SLNBx):
    • MSKCC Additional Node Nomogram - http://nomograms.mskcc.org/Breast/BreastAdditionalNonSLNMetastasesPage.aspx
      • Predicts probability of finding more positive nodes on completion axillary dissection after positive SLNBx.
      • 2003: PMID14654469 -- A nomogram for predicting the likelihood of additional nodal metastases in breast cancer patients with a positive sentinel node biopsy." (Van Zee, ASO)
    • MDACC Additional Nodes WITHOUT Neoadjuvant Chemotherapy - http://www3.mdanderson.org/app/medcalc/bc_nomogram2/index.cfm?pagename=nsln
      • Predicts probability of finding more nodes on completion axillary dissection after positive SLNBx in patients who have NOT received neoadjuvant chemotherapy.
      • 2010: (Mittendorf, SABC)
    • MDACC Additional Nodes AFTER Neoadjuvant Chemotherapy - http://www3.mdanderson.org/app/medcalc/bc_nomogram/index.cfm?pagename=nsln
      • Predicts probability of finding more nodes on completion axillary dissection after positive SLNBx in patients who have received neoadjuvant chemotherapy.
      • 2008: PMID 18442039 -- "Factors Predicting Additional Disease in the Axilla in Patients with Positive Sentinel Nodes after Neoadjuvant Chemotherapy." (Jeruss, Cancer)
• Breast Cancer Risk Assessment Tool (NCI) - risk of developing breast cancer
  • link

Cholangiocarcinoma

• Oregon: Extrahepatic cholangiocarcinoma, post-op RT

Colon Cancer

• MSKCC Colon Cancer DFS After Surgery

Glioblastoma

• EORTC Calculator

Gallbladder

• Oregon Adjuvant RT

Lung Cancer

• MSKCC Lung Cancer Risk After Smoking
• Oregon Adjuvant RT for NSCLC

Oral Cavity Cancer

• Cleveland Clinic Locoregional RFS - probability of 5-year LRRFS after surgery
• Oregon Post-op RT

Pancreas

• Oregon Adjuvant RT

Renal Cell

• Please see the renal cell carcinoma page

Prostate

• MSKCC Prostate Cancer Nomograms - multiple outcomes
• PSA doubling time calculator:
  • RTOG - opens Excel spreadsheet
  • Bellera (PDF) - graph paper method
• University of Michigan PSACalc - see PMID 19014779 "Determinants of Change in Prostate-Specific Antigen Over Time and Its Association With Recurrence After External Beam Radiation Therapy for Prostate Cancer in Five Large Cohorts." (Proust-Lima C, Int J Radiat Oncol Biol Phys. 2008 Nov 1;72(3):782-91)
• The Palpable Prostate blog - PSA Doubling Time. Provides a number of links to doubling time calculators
• Doubling Time - by Roth V. - Graphs (linear) and computes doubling time
• prostatecancerwatchfulwaiting.co.za - Excel spreadsheet. PSA Calculator. Graphs semi-log but only graphs PSA values > 1.0.

Sarcoma

• MSKCC Sarcoma Survival After Surgery

Patient information

Cancer Survivorship

• OncoLife - University of Pennsylvania
  • Create individualized survivorship plans of care based on the Institute of Medicine recommendations for cancer survivors.

About Radiation Oncology

• RT Answers - American Society for Radiation Oncology (ASTRO)
  • Information on radiation therapy written for patients by physicians and other members of the radiation oncology treatment team.