Talk:Hyperkalemic periodic paralysis

Human form

Since this article includes a section on the human form, I added in an outside link to MDA who currenly heads the research into (human) HKPP. (then I had to come back and re-edit TALK as the format went all wonky) 75.89.160.246 (talk) 15:41, 6 January 2009 (UTC) edited to add signature/link to registered user page as I was not logged in for preceeding comment: VulpineLady (talk) 15:03, 18 November 2009 (UTC)

"Suffocate to death" is redundant so I removed both occurrances of "to death". I added the HyperKPP human shorthand to complement the HYPP horse shorthand and used it in a few places to help condense the article a bit. Rephrased the paragraph about HYPP horses being dangerous to make it less absolute and more clear. Tweaked the link for and mentions of HypoKPP for correct capitalization and edited a few run-on sentences. I also added a mention in the treatment section that treatment needs to be customized by a professional to help forestall self-help gurus out there -- self treatment of Periodic Paralysis, in any form, can be deadly and should not be attempted...though you know someone will likely try.

There's also a reference to norma/normoKPP, but both spellings return No Page. I don't know enough about that variant to start one -- maybe a collaborative effort to draft and source is in order?

I did a quick wiki search for HKPP which is the customary human abbreviation and got routed to some military unit's page. Granted the abbreviation is the same, but most recently diagnosed human sufferers are going to look for the full name or the acronym. HKPP is used interchangeably for Hypo- and HyperKPP so maybe in this case a disambiguation page is warranted? Or if anyone knows how: a tweak of the search engine might take care of it. VulpineLady (talk) 15:52, 18 November 2009 (UTC)

Nice changes, they were much needed (I've been meaning the rewrite this page, but haven't had the time). The normokalemic variant isn't actually different from hyperkalemic cases, save the difference in serum potassium levels. It turns out that the "hyperkalemic" part of the name is a bit of a misnomer. --Dpryan (talk) 05:44, 19 November 2009 (UTC)

The addition of info on the human forms is nice to see. Overall, positive changes for the better! As far as the name change of the article, though, in the horse world "hyperkalemic" is the term used, and HYPP is a HUGE issue of major importance in quarter horse circles, so if you feel the need for any kind of name change, then maybe spin off the other stuff and leave this article named as is just for horses, with appropriate disambig links to other things. Montanabw^(talk)

What name change? Search Proposal: "Periodic Paralysis" disambig to HYPP, HypoKPP, and (once its drafted) NormaKPP. "HYPP" continues to route here. "HKPP" disambig to HYPP, HypoKPP, and the military page (and maybe Norma). That should cover all eventualities. Much as we all hate disambig pages I don't see any way around it here.

The thought of a seperate human page did occur to me; it's kind of a pain to dig through all the horse info (and I am an equestrienne ;) ) Maybe: HYPP page stays, spin off human to it's own "Hyperkalemic Periodic Paralysis (Human)/HKPP" like Hypo has, though Hypo is also HKPP in the shorthand. Search for "Periodic Paralysis" would HAVE to be to a disambig page though.

Norma being the same: do you mean genetically? The fact that potassium doesn't change makes it it's own disorder; genetics not withstanding, they symptoms are differential.

Glad you like the edits!! VulpineLady (talk) 17:10, 14 January 2010 (UTC)

Yes, normokalemic periodic paralysis is caused by a mutation that also results in hyperkalemic periodic paralysis in most patients. It's believed that the normokalemic variant simply represents phenotypic heterogeneity. It's not clear that potassium doesn't go up in normokalemic periodic paralysis patients, instead going from, perhaps, the lower to the upper end of normal. You bump into these fuzzy distinctions a lot once you start delving into the nitty-gritty of diseases. --Dpryan (talk) 23:56, 14 January 2010 (UTC)

What I can tell you is that horse people will search for HYPP and want to learn about the condition in horses, as it is a significant discussion in the Quarter Horse world. We could make articles for each type using parenthetical naming per the wiki MOS and the main term here becoming the disambig page, with all the abbreviations made into suitable redirects to the proper species, naming the rest Hyperkalemic periodic paralysis (human), Hyperkalemic periodic paralysis (horse), etc. Or keep this one for horses and make Hyperkalemic periodic paralysis (disambiguation) for everything else. I don't know if this is a minor condition in humans or something the pops up regularly? Whatever works. Montanabw^(talk) 00:38, 15 January 2010 (UTC)

Learned something new there, Dpryan O_O You have any links to the details you could drop me?

I'm not sure what the prevalence is in humans, but I do know that Hypo/Hyper/Norma all stand as three distinct conditions as well as three variations of the paralytic component of Andersen's Syndrome (which is considered extremely rare). I just noticed how sparse the ATS article is...I may have to do something about that ;)

Andersen's prevalence is currently estimated at 1 in 100,000 people. It is insidious, sneaky, and quite deadly. it consists of a triad of dysmorphic features (some listed on the wiki page), LQTS (also listed), and Periodic Paralysis (of any form). The really dangerous thing about ATS is the tendancy for the paralytic component to "flip". A hypokalemic needs to be careful that taking preventive potassium doesn't cause them to express as hyperkalemic...in ATS this is a distinct possibility (as is the converse, hyper-to-hypo).

Feel free to ping my talk page ;) VulpineLady (talk) 02:05, 11 March 2010 (UTC)

O_O OMG.....you...you're with the Ptacek study...OMG....*dives for the K-Dur to balance the palpatations* so very much do ping my talk page O_O VulpineLady (talk) 02:17, 11 March 2010 (UTC)

I have concern for my spouse about muscle periodic paralysis and severe weakness

This problem seems to be gettihg worse each year. Our doctor's can not place a dx. so we have a tough time getting any kind of money (SSI disability) Some days he is very active , his walk is abnormal and other days his arm or legs give out and he lays on the floor from 5-30 min. The he will need to use his cane. This has been going on since 2003. I will refer this article to our general Doc. This disease was initially blamed on taking of Mevacor (statins), which he took for at least 5 years, even increased while all the symptoms began, but the Cardiologist, refused that notion. Not sure this is the right page to write to, but my spouse ,age 53yr. is really concerned. Thank you (97.125.36.96 (talk) 19:32, 4 August 2011 (UTC))Cherie&Kevin Saxton

WP can't help you, we just write articles on the topic, best to look for medical web sites and chat boards. Sorry. Montanabw^(talk) 20:12, 4 August 2011 (UTC)

Propose article split

The following discussion is closed. Please do not modify it. Subsequent comments should be made in a new section. A summary of the conclusions reached follows.

No opposition, therefore split. DferDaisy (talk) 23:11, 19 August 2018 (UTC)

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I think it would be clearer for readers if the horse disease and the human disease were on different pages. The disease is more common in horses than humans. However, most (all?) articles about medical conditions which have the same name in humans and in veterinary species seem to have the primary page at the human disease, and use a disambiguator for the animal disease. Therefore, I suggest leaving the human disease at Hyperkalemic periodic paralysis, and moving the horse disease to Hyperkalemic periodic paralysis (equine). What does anyone else think? DferDaisy (talk) 21:23, 13 May 2018 (UTC)

The discussion above is closed. Please do not modify it. Subsequent comments should be made on the appropriate discussion page. No further edits should be made to this discussion.