RING finger protein 4 is a protein that in humans is encoded by the RNF4 gene.[5][6]

RNF4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRNF4, SLX5, SNURF, RES4-26, ring finger protein 4
External IDsOMIM: 602850; MGI: 1201691; HomoloGene: 37711; GeneCards: RNF4; OMA:RNF4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002938
NM_001185009
NM_001185010

NM_011278
NM_001304269
NM_001304270

RefSeq (protein)

NP_001171938
NP_001171939
NP_002929

NP_001291198
NP_001291199
NP_035408

Location (UCSC)Chr 4: 2.46 – 2.63 MbChr 5: 34.49 – 34.51 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene contains a RING finger domain and acts as a transcription factor. This protein has been shown to interact with, and inhibit the activity of, TRPS1, a transcription suppressor of GATA-mediated transcription. Transcription repressor ZNF278/PATZ1 is found to interact with this protein, and thus reduce the enhancement of androgen receptor-dependent transcription mediated by this protein. Studies of the mouse and rat counterparts suggested a role of this protein in spermatogenesis.[6]

Interactions

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RNF4 has been shown to interact with TCF20,[7] PATZ1[8][9] and Androgen receptor.[9][10][11] RNF4 has been shown to be responsible for the degradation of the Werner syndrome helicase in MSI-H cells after WRN inhibition.[12]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000063978Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029110Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Chiariotti L, Benvenuto G, Fedele M, Santoro M, Simeone A, Fusco A, Bruni CB (Jan 1998). "Identification and characterization of a novel RING-finger gene (RNF4) mapping at 4p16.3". Genomics. 47 (2): 258–65. doi:10.1006/geno.1997.5105. PMID 9479498.
  6. ^ a b "Entrez Gene: RNF4 ring finger protein 4".
  7. ^ Lyngsø C, Bouteiller G, Damgaard CK, Ryom D, Sanchez-Muñoz S, Nørby PL, Bonven BJ, Jørgensen P (Aug 2000). "Interaction between the transcription factor SPBP and the positive cofactor RNF4. An interplay between protein binding zinc fingers". The Journal of Biological Chemistry. 275 (34): 26144–9. doi:10.1074/jbc.M003405200. PMID 10849425.
  8. ^ Fedele M, Benvenuto G, Pero R, Majello B, Battista S, Lembo F, Vollono E, Day PM, Santoro M, Lania L, Bruni CB, Fusco A, Chiariotti L (Mar 2000). "A novel member of the BTB/POZ family, PATZ, associates with the RNF4 RING finger protein and acts as a transcriptional repressor". The Journal of Biological Chemistry. 275 (11): 7894–901. doi:10.1074/jbc.275.11.7894. PMID 10713105.
  9. ^ a b Pero R, Lembo F, Palmieri EA, Vitiello C, Fedele M, Fusco A, Bruni CB, Chiariotti L (Feb 2002). "PATZ attenuates the RNF4-mediated enhancement of androgen receptor-dependent transcription". The Journal of Biological Chemistry. 277 (5): 3280–5. doi:10.1074/jbc.M109491200. PMID 11719514.
  10. ^ Moilanen AM, Poukka H, Karvonen U, Häkli M, Jänne OA, Palvimo JJ (Sep 1998). "Identification of a novel RING finger protein as a coregulator in steroid receptor-mediated gene transcription". Molecular and Cellular Biology. 18 (9): 5128–39. doi:10.1128/mcb.18.9.5128. PMC 109098. PMID 9710597.
  11. ^ Poukka H, Aarnisalo P, Santti H, Jänne OA, Palvimo JJ (Jan 2000). "Coregulator small nuclear RING finger protein (SNURF) enhances Sp1- and steroid receptor-mediated transcription by different mechanisms". The Journal of Biological Chemistry. 275 (1): 571–9. doi:10.1074/jbc.275.1.571. PMID 10617653.
  12. ^ Rodríguez Pérez F, Natwick D, Schiff L, McSwiggen D, Heckert A, Huey M, Morrison H, Loo M, Miranda RG, Filbin J, Ortega J, Van Buren K, Murnock D, Tao A, Butler R, Cheng K, Tarvestad W, Zhang Z, Gonzalez E, Miller RM, Kelly M, Tang Y, Ho J, Anderson D, Bashore C, Basham S (July 2024). "WRN inhibition leads to its chromatin-associated degradation via the PIAS4-RNF4-p97/VCP axis". Nat. Commun. 15 (6059). doi:10.1038/s41467-024-50178-3. PMC 11258360. PMID 39025847.

Further reading

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