KIF18A

Kinesin family member KIF18A is a human protein encoded by the KIF18A gene. It is part of the kinesin family of motor proteins.

KIF18A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3LRE
Identifiers
Aliases	KIF18A, MS-PPP1R99, kinesin family member 18A
External IDs	OMIM: 611271; MGI: 2446977; HomoloGene: 41820; GeneCards: KIF18A; OMA:KIF18A - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11p14.1 Start 28,020,619 bp End 28,108,156 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 E3 Start 109,111,083 bp End 109,172,092 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone gonad testicle secondary oocyte ganglionic eminence sperm left testis right testis stromal cell of endometrium bone marrow Top expressed in zygote secondary oocyte primary oocyte spermatid fetal liver hematopoietic progenitor cell ventricular zone genital tubercle spermatocyte epiblast tail of embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding microtubule motor activity tubulin-dependent ATPase activity microtubule binding microtubule plus-end binding protein binding actin binding plus-end-directed microtubule motor activity ATP binding ATPase activity Cellular component cytoplasm cytosol cell projection kinetochore microtubule kinesin complex ruffle microtubule cytoskeleton microtubule organizing center mitotic spindle midzone caveola microtubule cytoskeleton nucleus kinetochore mitotic spindle astral microtubule Biological process antigen processing and presentation of exogenous peptide antigen via MHC class II male meiotic nuclear division regulation of microtubule cytoskeleton organization microtubule-based movement seminiferous tubule development protein transport microtubule depolymerization mitotic metaphase plate congression retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum cellular response to estradiol stimulus mitotic sister chromatid segregation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 81930 228421 Ensembl ENSG00000121621 ENSMUSG00000027115 UniProt Q8NI77 Q91WD7 RefSeq (mRNA) NM_031217 NM_139303 RefSeq (protein) NP_112494 NP_647464 Location (UCSC) Chr 11: 28.02 – 28.11 Mb Chr 2: 109.11 – 109.17 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

KIF18A is a plus-end directed motor protein, and migrates to the plus ends of the spindle during early mitosis. It first accumulates there during prophase and metaphase, and is depleted during anaphase.

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Luboshits G, Benayahu D (2005). "MS-KIF18A, new kinesin; structure and cellular expression". Gene. 351: 19–28. doi:10.1016/j.gene.2005.02.009. PMID 15878648.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Kinesin-like protein KIF18A