Fyn-related kinase

Fyn-related kinase (FRK, formerly tyrosine protein kinase 5) is an enzyme that in humans is encoded by the FRK gene.

FRK
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2D8J, 2DLY
Identifiers
Aliases	FRK, GTK, PTK5, RAK, Fyn-related kinase, fyn related Src family tyrosine kinase
External IDs	OMIM: 606573; MGI: 103265; HomoloGene: 48065; GeneCards: FRK; OMA:FRK - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6q22.1 Start 115,931,149 bp End 116,060,891 bp
Gene location (Mouse) Chr. Chromosome 10 (mouse) Band 10|10 B1 Start 34,359,395 bp End 34,487,274 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa mucosa of sigmoid colon epithelium of nasopharynx mucosa of paranasal sinus bronchial epithelial cell buccal mucosa cell palpebral conjunctiva parotid gland sperm corpus epididymis Top expressed in seminal vesicula jejunum duodenum renal pelvis conjunctival fornix large intestine colon inner renal medulla left colon Paneth cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity kinase activity protein binding signaling receptor binding ATP binding non-membrane spanning protein tyrosine kinase activity protein tyrosine kinase activity Cellular component extrinsic component of cytoplasmic side of plasma membrane plasma membrane intracellular anatomical structure extracellular exosome extracellular region nucleus nucleoplasm cytoplasm azurophil granule lumen specific granule lumen cytosol Biological process cell differentiation phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway negative regulation of transcription by RNA polymerase II protein phosphorylation peptidyl-tyrosine autophosphorylation innate immune response negative regulation of cell population proliferation neutrophil degranulation cell migration Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2444 14302 Ensembl ENSG00000111816 ENSMUSG00000019779 UniProt P42685 Q922K9 RefSeq (mRNA) NM_002031 NM_001159544 NM_010237 NM_001358769 RefSeq (protein) NP_002022 NP_001153016 NP_034367 NP_001345698 Location (UCSC) Chr 6: 115.93 – 116.06 Mb Chr 10: 34.36 – 34.49 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth.

Interactions

FRK has been shown to interact with retinoblastoma protein.

Further reading

• Serfas MS, Tyner AL (2003). "Brk, Srm, Frk, and Src42A form a distinct family of intracellular Src-like tyrosine kinases". Oncol. Res. 13 (6–10): 409–19. doi:10.3727/096504003108748438. PMID 12725532.
• Craven RJ, Cance WG, Liu ET (1995). "The nuclear tyrosine kinase Rak associates with the retinoblastoma protein pRb". Cancer Res. 55 (18): 3969–72. PMID 7664264.
• Cance WG, Craven RJ, Bergman M, et al. (1995). "Rak, a novel nuclear tyrosine kinase expressed in epithelial cells". Cell Growth Differ. 5 (12): 1347–55. PMID 7696183.
• Cance WG, Craven RJ, Weiner TM, Liu ET (1993). "Novel protein kinases expressed in human breast cancer". Int. J. Cancer. 54 (4): 571–7. doi:10.1002/ijc.2910540409. PMID 8099900. S2CID 23352078.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Meyer T, Xu L, Chang J, et al. (2003). "Breast cancer cell line proliferation blocked by the Src-related Rak tyrosine kinase". Int. J. Cancer. 104 (2): 139–46. doi:10.1002/ijc.10925. PMID 12569567. S2CID 24095233.
• Watanabe T, Ohnuma T, Shibata N, et al. (2004). "No genetic association between Fyn kinase gene polymorphisms (-93A/G, IVS10+37T/C and Ex12+894T/G) and Japanese sporadic Alzheimer's disease". Neurosci. Lett. 360 (1–2): 109–11. doi:10.1016/j.neulet.2004.02.046. PMID 15082191. S2CID 11972631.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Zhang Y, Wolf-Yadlin A, Ross PL, et al. (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules". Mol. Cell. Proteomics. 4 (9): 1240–50. doi:10.1074/mcp.M500089-MCP200. PMID 15951569.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.