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Submission declined on 17 December 2024 by WeirdNAnnoyed (talk).
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This draft has been resubmitted and is currently awaiting re-review. |
- Comment: Second paragraph is copied verbatim from Reference 2. WeirdNAnnoyed (talk) 22:47, 17 December 2024 (UTC)
Clinical data | |
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Other names | Flumefenine, R-760. |
Identifiers | |
CAS Number | |
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ChemSpider | |
Chemical and physical data | |
Formula | C19H19F2NO2 |
Molar mass | 331.363 g·mol−1 |
3D model (JSmol) | |
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Flazalone is an anti-inflammatory substance[1] that has not been approved as a drug.
According to Shaomeng Wang & co-workers, replacement of the para-fluoro halogen with a meta,para-dichloro substitution resulted in dopamine reuptake inhibitors useful in treating cocaine addiction.[2][3]
References
edit- ^ "Flazalone". Inxight Drugs. The National Center for Advancing Translational Sciences (NCATS).
- ^ Wang S, Sakamuri S, Enyedy IJ, Kozikowski AP, Deschaux O, Bandyopadhyay BC, Tella SR, Zaman WA, Johnson KM (February 2000). "Discovery of a novel dopamine transporter inhibitor, 4-hydroxy-1-methyl-4-(4-methylphenyl)-3-piperidyl 4-methylphenyl ketone, as a potential cocaine antagonist through 3D-database pharmacophore searching. Molecular modeling, structure-activity relationships, and behavioral pharmacological studies". Journal of Medicinal Chemistry. 43 (3): 351–60. doi:10.1021/jm990516x. PMID 10669562.
- ^ Wang S, Sakamuri S, Enyedy IJ, Kozikowski AP, Zaman WA, Johnson KM (July 2001). "Molecular modeling, structure--activity relationships and functional antagonism studies of 4-hydroxy-1-methyl-4-(4-methylphenyl)-3-piperidyl 4-methylphenyl ketones as a novel class of dopamine transporter inhibitors". Bioorganic & Medicinal Chemistry. 9 (7): 1753–64. doi:10.1016/s0968-0896(01)00090-6. PMID 11425577.
This submission has now been cleaned of the above-noted copyright violation and its history redacted by an administrator to remove the infringement. If re-submitted (and subsequent additions do not reintroduce copyright problems), the content may be assessed on other grounds.