• Comment: Second paragraph is copied verbatim from Reference 2. WeirdNAnnoyed (talk) 22:47, 17 December 2024 (UTC)


Flazalone
Clinical data
Other namesFlumefenine, R-760.
Identifiers
CAS Number
PubChem CID
ChemSpider
Chemical and physical data
FormulaC19H19F2NO2
Molar mass331.363 g·mol−1
3D model (JSmol)
  • CN1CCC(C(C1)C(=O)C2=CC=C(C=C2)F)(C3=CC=C(C=C3)F)O
  • InChI=1S/C19H19F2NO2/c1-22-11-10-19(24,14-4-8-16(21)9-5-14)17(12-22)18(23)13-2-6-15(20)7-3-13/h2-9,17,24H,10-12H2,1H3
  • Key:PPQZABOURJVKNI-UHFFFAOYSA-N

Flazalone is an anti-inflammatory substance[1] that has not been approved as a drug.


According to Shaomeng Wang & co-workers, replacement of the para-fluoro halogen with a meta,para-dichloro substitution resulted in dopamine reuptake inhibitors useful in treating cocaine addiction.[2][3]

References

edit
  1. ^ "Flazalone". Inxight Drugs. The National Center for Advancing Translational Sciences (NCATS).
  2. ^ Wang S, Sakamuri S, Enyedy IJ, Kozikowski AP, Deschaux O, Bandyopadhyay BC, Tella SR, Zaman WA, Johnson KM (February 2000). "Discovery of a novel dopamine transporter inhibitor, 4-hydroxy-1-methyl-4-(4-methylphenyl)-3-piperidyl 4-methylphenyl ketone, as a potential cocaine antagonist through 3D-database pharmacophore searching. Molecular modeling, structure-activity relationships, and behavioral pharmacological studies". Journal of Medicinal Chemistry. 43 (3): 351–60. doi:10.1021/jm990516x. PMID 10669562.
  3. ^ Wang S, Sakamuri S, Enyedy IJ, Kozikowski AP, Zaman WA, Johnson KM (July 2001). "Molecular modeling, structure--activity relationships and functional antagonism studies of 4-hydroxy-1-methyl-4-(4-methylphenyl)-3-piperidyl 4-methylphenyl ketones as a novel class of dopamine transporter inhibitors". Bioorganic & Medicinal Chemistry. 9 (7): 1753–64. doi:10.1016/s0968-0896(01)00090-6. PMID 11425577.