Adipocyte Enhancer-Binding Protein is a zinc finger protein that in humans is encoded by the evolutionarily well-conserved gene AEBP2. It was initially identified due to its binding capability to the promoter[5] of the adipocyte P2 gene, and was therefore named Adipocyte Enhancer Binding Protein 2. AEBP2 is a potential targeting protein for the mammalian Polycomb Repression Complex 2 (PRC2).[6]

AEBP2
Identifiers
AliasesAEBP2, AE binding protein 2
External IDsOMIM: 617934; MGI: 1338038; HomoloGene: 40690; GeneCards: AEBP2; OMA:AEBP2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001114176
NM_001267043
NM_153207
NM_001363736

NM_001005605
NM_009637
NM_178803
NM_001309436
NM_001309437

RefSeq (protein)

NP_001107648
NP_001253972
NP_694939
NP_001350665

NP_001005605
NP_001296365
NP_001296366
NP_033767
NP_848918

Location (UCSC)Chr 12: 19.4 – 19.72 MbChr 6: 140.57 – 140.62 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

edit

AEBP2 is a DNA-binding transcriptional repressor. It may interact with and stimulate the activity of the PRC2 complex.[7]

AEBP2 may regulate the migration and development of the neural crest cells through the PRC2-mediated epigenetic mechanism and is most likely a targeting protein for the mammalian PRC2 complex.[8]

Clinical significance

edit

Diseases associated with AEBP2 include Waardenburg's syndrome, and Hirschsprung's disease.[8]

References

edit
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000139154Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030232Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Imhof, Axel; Kim, Hana; Bakshi, Arundhati; Kim, Joomyeong (2015). "Retrotransposon-Derived Promoter of Mammalian Aebp2". PLOS ONE. 10 (4): e0126966. Bibcode:2015PLoSO..1026966K. doi:10.1371/journal.pone.0126966. ISSN 1932-6203. PMC 4411029. PMID 25915901.
  6. ^ Kim H, Kang K, Ekram MB, Roh TY, Kim J (2011). "Aebp2 as an epigenetic regulator for neural crest cells". PLOS ONE. 6 (9): e25174. Bibcode:2011PLoSO...625174K. doi:10.1371/journal.pone.0025174. PMID 21949878.
  7. ^ Cao R, Zhang Y (July 2004). "SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex". Mol. Cell. 15 (1): 57–67. doi:10.1016/j.molcel.2004.06.020. PMID 15225548.
  8. ^ a b Kim H, Kang K, Kim J (2009). "AEBP2 as a potential targeting protein for Polycomb Repression Complex PRC2". Nucleic Acids Res. 37 (9): 2940–50. doi:10.1093/nar/gkp149. PMC 2685092. PMID 19293275.
edit