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A novel fibre optic monitor for VHEE UHDR beam monitoring: first tests at CLEAR
/ Bateman, Joseph (JAI, UK ; CERN) ; Buchanan, Emma (CERN) ; Corsini, Roberto (CERN) ; Gerbershagen, Alexander (Groningen U.) ; Ortega Ruiz, Inaki (CERN) ; Dosanjh, Manjit (JAI, UK ; CERN) ; Farabolini, Wilfrid (CERN) ; Rieker, Vilde (CERN ; Oslo U.) ; Korysko, Pierre (JAI, UK ; CERN) ; Malyzhenkov, Alexander (CERN)
Beam monitoring for Ultra High Dose Rate (UHDR) radiation therapy using pulsed beams, i.e. Very High Energy Electrons (VHEE), is a major challenge. [...]
2023
- Published in : JACoW IPAC 2023 (2023) THPL041
Fulltext: PDF;
In : 14th International Particle Accelerator Conference (IPAC 2023), Venice, Italy, 7 - 12 May 2023, pp.THPL041
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Development of a novel fibre optic beam profile and dose monitor for very high energy electron radiotherapy at ultrahigh dose rates
/ Bateman, Joseph J (JAI, UK) ; Buchanan, Emma (CERN) ; Corsini, Roberto (CERN) ; Farabolini, Wilfrid (CERN) ; Korysko, Pierre (JAI, UK ; CERN) ; Larsen, Robert Garbrecht (CERN ; Groningen U.) ; Malyzhenkov, Alexander (CERN) ; Ruiz, Iñaki Ortega (CERN) ; Rieker, Vilde (CERN ; Oslo U.) ; Gerbershagen, Alexander (Groningen U.)
Objective. Very high energy electrons (VHEE) in the range of 50–250 MeV are of interest for treating deep-seated tumours with FLASH radiotherapy (RT). [...]
2024 - 16 p.
- Published in : Phys. Med. Biol. 69 (2024) 085006
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Testing the Properties of Beam-Dose Monitors for VHEE-FLASH Radiation Therapy
/ Bateman, Joseph (JAI, UK) ; Burrows, Philip (JAI, UK) ; Corsini, Roberto (CERN) ; Dosanjh, Manjit (CERN) ; Dyks, Luke (JAI, UK) ; Farabolini, Wilfrid (CERN) ; Gerbershagen, Alexander (CERN) ; Heracleous, Natalie (CERN) ; Korysko, Pierre (CERN) ; Morales Vigo, Sara (CERN) et al.
Very High Energy Electrons (VHEE) of 50 - 250 MeV are an attractive choice for FLASH radiation therapy (RT). Before VHEE-FLASH RT can be considered for clinical use, a reliable dosimetric and beam monitoring system needs to be developed, able to measure the dose delivered to the patient in real-time and cut off the beam in the event of a machine fault to prevent overdosing the patient. [...]
2022 - 4 p.
- Published in : JACoW IPAC 2022 (2022) 3018-3021
Fulltext: PDF;
In : 13th International Particle Accelerator Conference (IPAC 2022), Bangkok, Thailand, 12 - 17 Jun 2022, pp.3018-3021
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Plastic Scintillator Dosimetry of Ultrahigh Dose-Rate 200 MeV Electrons at CLEAR
/ Hart, Alexander (Victoria U.) ; Giguère, Cloé (Laval U.) ; Bateman, Joseph (Oxford U.) ; Korysko, Pierre (Oxford U.) ; Farabolini, Wilfrid (CERN) ; Rieker, Vilde (CERN ; Oslo U.) ; Esplen, Nolan (Victoria U.) ; Corsini, Roberto (CERN) ; Dosanjh, Manjit (Oxford U.) ; Beaulieu, Luc (Laval U.) et al.
Very-high-energy electron (VHEE) beams with energies greater than 100 MeV may be promising candidates for FLASH radiotherapy due to their favorable dose distributions and accessibility of ultrahigh dose rates (UHDRs). Combining VHEE with the normal tissue-sparing FLASH effect of UHDR radiotherapy could improve patient outcomes. [...]
2024 - 9 p.
- Published in : IEEE Sensors J. 24 (2024) 14229-14237
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Methods for VHEE/FLASH Radiotherapy Studies and High Dose Rate Dosimetry at the CLEAR User Facility
/ Korysko, Pierre (U. Oxford (main) ; CERN) ; Bateman, Joseph (U. Oxford (main) ; CERN) ; Corsini, Roberto (CERN) ; Dyks, Luke (CERN) ; Farabolini, Wilfrid (CERN) ; Rieker, Vilde (CERN) ; Robertson, Cameron (U. Oxford (main) ; CERN)
The CERN Linear Electron Accelerator for Research (CLEAR), operating since 2017, is a user facility providing electron beams for a varied and large range of experiments. The accelerator can generate a 60-220 MeV electron beam and it was recently selected to study the feasibility of using Very High Energy Electrons (VHEE) at Ultra High Dose Rate (UHDR) for cancer radiotherapy. [...]
2022 - 4 p.
- Published in : JACoW LINAC 2022 (2022) 758-761
Fulltext: PDF;
In : 31st Linear Accelerator Conference (LINAC22), Liverpool, UK, 28 Aug - 2 Sep 2022, pp.758-761
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VHEE High Dose Rate Dosimetry Studies in CLEAR
/ Rieker, Vilde (CERN) ; Bateman, Joseph (JAI, UK ; CERN) ; Corsini, Roberto (CERN) ; Dyks, Luke (CERN ; Oxford U.) ; Farabolini, Wilfrid (IRFU, Saclay) ; Korysko, Pierre (Oxford U. ; CERN)
The 200 MeV electron beam of the CERN Linear Accelerator for Research (CLEAR) user facility at CERN has been intensively used to study the potential use of Very High Energy Electrons (VHEE) in cancer radiotherapy. In particular, irradiation tests have been performed in the high dose rate regime, which has gained a lot of interest for the so called FLASH biological effect, in which cancer cells are damaged while healthy tissue is largely spared. [...]
2022 - 4 p.
- Published in : JACoW IPAC 2022 (2022) 3026-3029
Fulltext: PDF;
In : 13th International Particle Accelerator Conference (IPAC 2022), Bangkok, Thailand, 12 - 17 Jun 2022, pp.3026-3029
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The challenge of ionisation chamber dosimetry in ultra-short pulsed high dose-rate Very High Energy Electron beams
/ McManus, M (Teddington, Natl. Phys. Lab ; U. Coll. London) ; Romano, F (INFN, Catania ; Teddington, Natl. Phys. Lab) ; Lee, N D (Teddington, Natl. Phys. Lab) ; Farabolini, W (CERN ; IRFU, Saclay) ; Gilardi, A (CERN) ; Royle, G (U. Coll. London) ; Palmans, H (Medaustron, Vienna ; Teddington, Natl. Phys. Lab) ; Subiel, A (Teddington, Natl. Phys. Lab)
High dose-rate radiotherapy, known as FLASH, has been shown to increase the differential response between healthy and tumour tissue. Moreover, Very High Energy Electrons (VHEEs) provide more favourable dose distributions than conventional radiotherapy electron and photon beams. [...]
2020 - 11 p.
- Published in : Sci. Rep. 10 (2020) 9089
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VHEE beam dosimetry at CERN Linear Electron Accelerator for Research under ultra-high dose rate conditions
/ Poppinga, Daniela (Unlisted, DE) ; Kranzer, Rafael (Carl von Ossietzky U., Oldenburg (main)) ; Farabolini, Wilfrid (CERN ; IRFU, Saclay, DACM) ; Gilardi, Antonio (CERN ; U. Naples (main) ; INFN, Naples) ; Corsini, Roberto (CERN) ; Wyrwoll, Vanessa (CERN) ; Looe, Hui Khee (Carl von Ossietzky U., Oldenburg (main)) ; Delfs, Björn (Carl von Ossietzky U., Oldenburg (main)) ; Gabrisch, Lukas (Carl von Ossietzky U., Oldenburg (main)) ; Poppe, Björn (INFN, Naples)
The aim of this work is the dosimetric characterization of a plane parallel ionization chamber under
defined beam setups at the CERN Linear Electron Accelerator for Research (CLEAR). A laser driven
electron beam with energy of 200 MeV at two different field sizes of approximately 3.5 mm FWHM
and approximately 7 mm FWHM were used at different pulse structures. [...]
2020 - 11 p.
- Published in : Biomedical Physics & Engineering Express 7 (2020) 015012
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VHEE FLASH sparing effect measured at CLEAR, CERN with DNA damage of pBR322 plasmid as a biological endpoint
/ Wanstall, Hannah C (Manchester U. ; Daresbury) ; Korysko, Pierre (Oxford U. ; CERN) ; Farabolini, Wilfred (CERN) ; Corsini, Roberto (CERN) ; Bateman, Joseph J (Oxford U., Theor. Phys.) ; Rieker, Vilde (CERN ; Oslo U.) ; Hemming, Abigail (U. Manchester (main)) ; Henthorn, Nicholas T (U. Manchester (main) ; Manchester U.) ; Merchant, Michael J (Manchester U.) ; Santina, Elham (Manchester U.) et al.
Ultra-high dose rate (UHDR) irradiation has been shown to have a sparing effect on healthy tissue, an effect known as ‘FLASH’. This effect has been studied across several radiation modalities, including photons, protons and clinical energy electrons, however, very little data is available for the effect of FLASH with Very High Energy Electrons (VHEE). [...]
2024 - 13 p.
- Published in : Sci. Rep. 14 (2024) 14803
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Updates, Status and Experiments of CLEAR, the CERN Linear Electron Accelerator for Research
/ Korysko, Pierre (Oxford U.) ; Bateman, Joseph (JAI, UK) ; Corsini, Roberto (CERN) ; Dosanjh, Manjit (CERN) ; Dyks, Luke (CERN) ; Farabolini, Wilfrid (IRFU, Saclay) ; Gilardi, Antonio (CERN) ; Rieker, Vilde (CERN) ; Robertson, Cameron (JAI, UK) ; Sjobak, Kyrre (Oslo U.)
The CERN Linear Accelerator for Research (CLEAR) at CERN is a test facility using a 200 MeV electron beam. In 2020 and 2021, a few hardware upgrades were done: comparators for position measurements were added on components, the in-air experimental area was re-arranged in order to provide more space, a robotic system was built to enable remote samples manipulations for irradiation studies, the BPM reading system was optimized and the laser double-bunch system implemented to allow for a doubling of the electron bunch frequency from 1.5 GHz to 3 GHz. [...]
2022 - 4 p.
- Published in : JACoW IPAC 2022 (2022) 3022-3025
Fulltext: PDF;
In : 13th International Particle Accelerator Conference (IPAC 2022), Bangkok, Thailand, 12 - 17 Jun 2022, pp.3022-3025
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