DLGAP4

DLGAP4
Identifikatori
Aliasi	DLGAP4
Vanjski ID-jevi	OMIM: 616191 MGI: 2138865 HomoloGene: 8935 GeneCards: DLGAP4
Lokacija gena (čovjek) Hrom. Hromosom 20 (čovjek) Bend 20q11.23 Početak 36,306,336 bp Kraj 36,528,637 bp
Lokacija gena (miš) Hrom. Hromosom 2 (miš) Bend 2|2 H1 Početak 156,455,625 bp Kraj 156,606,283 bp
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • GO:0001948, GO:0016582 vezivanje za proteine • protein domain specific binding Ćelijska komponenta • membrana • ćelijska membrana • sinapsa • Nervno-mišićna veza • glutamatergic synapse • cholinergic synapse • postsynaptic specialization Biološki proces • signaling Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	22839	228836
Ensembl	ENSG00000080845	ENSMUSG00000061689
UniProt	Q9Y2H0	B1AZP2
RefSeq (mRNK)	NM_001042486 NM_014902 NM_183006 NM_001365621	NM_001042487 NM_001042488 NM_001277186 NM_001277187 NM_146128
RefSeq (bjelančevina)	NP_001035951 NP_055717 NP_892118 NP_001352550	NP_001035952 NP_001035953 NP_001264115 NP_001264116 NP_666240
Lokacija (UCSC)	Chr 20: 36.31 – 36.53 Mb	Chr 2: 156.46 – 156.61 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Velikodiskni pridruženi protein 4 (DAP-4), poznat i kao SAP90/ PSD-95-združeni protein 4 (SAPAP-4) je protein koji je kod ljudi kodiran genom DLGAP4.

Funkcija

DAP-4 je gvanilat-kinaza povezana s membranom koja se nalazi u postsinapsnoj gustoći u nervnih ćelija. To je signalna molekula, koja može stupiti u interakciju s kalijevim kanalom i receptorima, kao i drugim signalnim molekulama. DAP-4 može komunicirati sa PSD-95 preko svog domena gvanilat-kinaze i može biti uključen u klasteriranje PSD-95, u regiji postsinapsne gustoće. Kodirani protein je jedan od najmanje četiri slična proteina koja su pronađena. Za ovaj gen pronađene su alternativno prerađene varijante transkripata, koje kodiraju različite izoforme.

Dopunska literatura

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• Chen HJ, Rojas-Soto M, Oguni A, Kennedy MB (1998). "A synaptic Ras-GTPase activating protein (p135 SynGAP) inhibited by CaM kinase II". Neuron. 20 (5): 895–904. doi:10.1016/S0896-6273(00)80471-7. PMID 9620694.
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• Pei L, Teves RL, Wallace MC, Gurd JW (2001). "Transient cerebral ischemia increases tyrosine phosphorylation of the synaptic RAS-GTPase activating protein, SynGAP". J. Cereb. Blood Flow Metab. 21 (8): 955–63. doi:10.1097/00004647-200108000-00008. PMID 11487731.
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• Riefler GM, Balasingam G, Lucas KG, et al. (2003). "Exocyst complex subunit sec8 binds to postsynaptic density protein-95 (PSD-95): a novel interaction regulated by cypin (cytosolic PSD-95 interactor)". Biochem. J. 373 (Pt 1): 49–55. doi:10.1042/BJ20021838. PMC 1223477. PMID 12675619.
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• Song B, Yan XB, Zhang GY (2004). "PSD-95 promotes CaMKII-catalyzed serine phosphorylation of the synaptic RAS-GTPase activating protein SynGAP after transient brain ischemia in rat hippocampus". Brain Res. 1005 (1–2): 44–50. doi:10.1016/j.brainres.2004.01.032. PMID 15044063.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.