Cinkoprstni protein 516 je protein koji je kod ljudi kodiran genom ZNF516.[5]

ZNF516
Identifikatori
AliasiZNF516
Vanjski ID-jeviOMIM: 615114 MGI: 2443957 HomoloGene: 37122 GeneCards: ZNF516
Lokacija gena (čovjek)
Hromosom 18 (čovjek)
Hrom.Hromosom 18 (čovjek)[1]
Hromosom 18 (čovjek)
Genomska lokacija za ZNF516
Genomska lokacija za ZNF516
Bend18q23Početak76,357,682 bp[1]
Kraj76,495,242 bp[1]
Lokacija gena (miš)
Hromosom 18 (miš)
Hrom.Hromosom 18 (miš)[2]
Hromosom 18 (miš)
Genomska lokacija za ZNF516
Genomska lokacija za ZNF516
Bend18|18 E3Početak82,928,788 bp[2]
Kraj83,023,439 bp[2]
Ontologija gena
Molekularna funkcija GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity
sequence-specific DNA binding
vezivanje sa DNK
GO:0001158 cis-regulatory region sequence-specific DNA binding
vezivanje iona metala
nucleic acid binding
GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific
Ćelijska komponenta jedro
Biološki proces multicellular organism development
GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated
response to cold
adipose tissue development
GO:0009373 regulation of transcription, DNA-templated
transcription by RNA polymerase II
GO:0072468 Transdukcija signala
brown fat cell differentiation
transcription, DNA-templated
GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II
positive regulation of cold-induced thermogenesis
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_014643

NM_001177464
NM_183033

RefSeq (bjelančevina)

NP_055458

NP_001170935
NP_898854

Lokacija (UCSC)Chr 18: 76.36 – 76.5 MbChr 18: 82.93 – 83.02 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Dužina polipeptidnog lanca je 1.163 aminokiseline, sa molekulskom težinom od 124.289-[6]

Aminokiselinska sekvenca

Simboli
1020304050
MDRNREAEMELRRGPSPTRAGRGHEVDGDKATCHTCCICGKSFPFQSSLS
QHMRKHTGEKPYKCPYCDHRASQKGNLKIHIRSHRTGTLIQGHEPEAGEA
PLGEMRASEGLDACASPTKSASACNRLLNGASQADGARVLNGASQADSGR
VLLRSSKKGAEGSACAPGEAKAAVQCSFCKSQFERKKDLELHVHQAHKPF
KCRLCSYATLREESLLSHIERDHITAQGPGSGEACVENGKPELSPGEFPC
EVCGQAFSQTWFLKAHMKKHRGSFDHGCHICGRRFKEPWFLKNHMKAHGP
KTGSKNRPKSELDPIATINNVVQEEVIVAGLSLYEVCAKCGNLFTNLDSL
NAHNAIHRRVEASRTRAPAEEGAEGPSDTKQFFLQCLNLRPSAAGDSCPG
TQAGRRVAELDPVNSYQAWQLATRGKVAEPAEYLKYGAWDEALAGDVAFD
KDRREYVLVSQEKRKREQDAPAAQGPPRKRASGPGDPAPAGHLDPRSAAR
PNRRAAATTGQGKSSECFECGKIFRTYHQMVLHSRVHRRARRERDSDGDR
AARARCGSLSEGDSASQPSSPGSACAAADSPGSGLADEAAEDSGEEGAPE
PAPGGQPRRCCFSEEVTSTELSSGDQSHKMGDNASERDTGESKAGIAASV
SILENSSRETSRRQEQHRFSMDLKMPAFHPKQEVPVPGDGVEFPSSTGAE
GQTGHPAEKLSDLHNKEHSGGGKRALAPDLMPLDLSARSTRDDPSNKETA
SSLQAALVVHPCPYCSHKTYYPEVLWMHKRIWHRVSCNSVAPPWIQPNGY
KSIRSNLVFLSRSGRTGPPPALGGKECQPLLLARFTRTQVPGGMPGSKSG
SSPLGVVTKAASMPKNKESHSGGPCALWAPGPDGYRQTKPCHGQEPHGAA
TQGPLAKPRQEASSKPVPAPGGGGFSRSATPTPTVIARAGAQPSANSKPV
EKFGVPPAGAGFAPTNKHSAPDSLKAKFSAQPQGPPPAKGEGGAPPLPPR
EPPSKAAQELRTLATCAAGSRGDAALQAQPGVAGAPPVLHSIKQEPVAEG
HEKRLDILNIFKTYIPKDFATLYQGWGVSGPGLEHRGTLRTQARPGEFVC
IECGKSFHQPGHLRAHMRAHSVVFESDGPRGSEVHTTSADAPKQGRDHSN
TGTVQTVPLRKGT

Funkcija

uredi

Proteini cinkovog prsta vežu nukleinske kiseline i imaju važnu ulogu u različitim ćelijskim funkcijama, uključujući proliferacija ćelija, diferencijacija i apoptozu. Ovaj gen kodira protein cinkovog prsta i pripada porodici proteina cinka-prsta tipa Krüppel C2H2. Može biti uključen u proces transkripcije.

Reference

uredi
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000101493 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000058881 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Zinc finger protein 516".
  6. ^ "UniProt, Q92618". Pristupljeno 12. 9. 2017.

Dopunska literatura

uredi