ZNF268

Protein cinkovog prsta 268 je protein koji je kod ljudi kodiran genom ZNF268.

ZNF268
Dostupne strukture PDB Pretraga Human UniProta: PDBe RCSB Spisak PDB ID kodova 2EL4, 2EL5, 2EL6, 2EM1, 2EMV, 2EMW, 2EMX, 2EMY, 2EN0, 2EN6, 2EN7, 2EOF, 2EOG, 2EOI, 2EOJ, 2EOK, 2EOL, 2EOP, 2EPV, 2EPW, 2EPY, 2YTF, 2YTQ
Identifikatori
Aliasi	ZNF268
Vanjski ID-jevi	OMIM: 604753 HomoloGene: 124392 GeneCards: ZNF268
Lokacija gena (čovjek) Hrom. Hromosom 12 (čovjek) Bend 12q24.33 Početak 133,181,409 bp Kraj 133,214,832 bp
Ontologija gena Molekularna funkcija • nucleic acid binding • vezivanje sa DNK • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • vezivanje iona metala • GO:0001948, GO:0016582 vezivanje za proteine • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Ćelijska komponenta • intracellular anatomical structure • citoplazma • actin cytoskeleton • jedro • citosol Biološki proces • GO:0009373 regulation of transcription, DNA-templated • Ćelijska diferencijacija • positive regulation of protein phosphorylation • GO:1903364 positive regulation of protein catabolic process • regulation of protein heterodimerization activity • positive regulation of cell migration • cellular response to tumor necrosis factor • negative regulation of apoptotic process • GO:1901227 negative regulation of transcription by RNA polymerase II • positive regulation of protein homodimerization activity • transcription, DNA-templated • positive regulation of cell differentiation • positive regulation of cell population proliferation • regulation of mitotic cell cycle • positive regulation of apoptotic process • negative regulation of cell population proliferation • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • positive regulation of NIK/NF-kappaB signaling Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	10795	n/a
Ensembl	ENSG00000090612	n/a
UniProt	Q14587	n/a
RefSeq (mRNK)	NM_152943 NM_001165881 NM_001165882 NM_001165883 NM_001165884 NM_001165885 NM_001165886 NM_001165887 NM_003415	n/a
RefSeq (bjelančevina)	NP_001159353 NP_001159354 NP_001159355 NP_001159356 NP_001159357 NP_001159358 NP_001159359 NP_003406 NP_694422	n/a
Lokacija (UCSC)	Chr 12: 133.18 – 133.21 Mb	n/a
PubMed pretraga		n/a
Wikipodaci
Pogledaj/uredi – čovjek

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 94 aminokiseline, a molekulska težina 11 068 Da.

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10		20		30		40		50
MDVFVDFTWE		EWQLLDPAQK		CLYRSVMLEN		YSNLVSLGYQ		HTKPDIIFKL
EQGEELCMVQ		AQVPNQTCPN		TVWKIDDLMD		WHQENKDKLG		STAK

Dopunska literatura

• Shao H, Zhu C, Zhao Z, et al. (2006). "KRAB-containing zinc finger gene ZNF268 encodes multiple alternatively spliced isoforms that contain transcription regulatory domains". Int. J. Mol. Med. 18 (3): 457–63. doi:10.3892/ijmm.18.3.457. PMID 16865230.
• Guo MX, Wang D, Shao HJ, et al. (2006). "Transcription of human zinc finger ZNF268 gene requires an intragenic promoter element". J. Biol. Chem. 281 (34): 24623–36. doi:10.1074/jbc.M602753200. PMID 16787922.
• Sun Y, Shao H, Li Z, et al. (2005). "ZNF268, a novel kruppel-like zinc finger protein, is implicated in early human liver development". Int. J. Mol. Med. 14 (6): 971–5. doi:10.3892/ijmm.14.6.971. PMID 15547661.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Sun Y, Gou DM, Liu H, et al. (2004). "The KRAB domain of zinc finger gene ZNF268: a potential transcriptional repressor". IUBMB Life. 55 (3): 127–31. doi:10.1080/1521654031000110208. PMID 12822888. S2CID 43391168.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gou DM, Sun Y, Gao L, et al. (2001). "Cloning and characterization of a novel Krüppel-like zinc finger gene, ZNF268, expressed in early human embryo". Biochim. Biophys. Acta. 1518 (3): 306–10. doi:10.1016/s0167-4781(01)00194-4. hdl:10397/34032. PMID 11311945.