Protein 1 sa transmembranskim inhibitornim motivom BAX jest protein koji je kod ljudi kodiran genom TMBIM1 sa hromosoma 2.[5][6]

TMBIM1
Identifikatori
AliasiTMBIM1
Vanjski ID-jeviOMIM: 610364 MGI: 1916910 HomoloGene: 36404 GeneCards: TMBIM1
Lokacija gena (čovjek)
Hromosom 2 (čovjek)
Hrom.Hromosom 2 (čovjek)[1]
Hromosom 2 (čovjek)
Genomska lokacija za TMBIM1
Genomska lokacija za TMBIM1
Bend2q35Početak218,274,197 bp[1]
Kraj218,292,586 bp[1]
Lokacija gena (miš)
Hromosom 1 (miš)
Hrom.Hromosom 1 (miš)[2]
Hromosom 1 (miš)
Genomska lokacija za TMBIM1
Genomska lokacija za TMBIM1
Bend1|1 C3Početak74,327,406 bp[2]
Kraj74,344,781 bp[2]
Obrazac RNK ekspresije
Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija death receptor binding
Ćelijska komponenta integral component of membrane
lysosomal membrane
endozom
Golđijev aparat
Lizozom
endosome membrane
Egzosom
membrana
ćelijska membrana
specific granule membrane
intracellular membrane-bounded organelle
Biološki proces negative regulation of Fas signaling pathway
positive regulation of blood vessel remodeling
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0048553 negative regulation of catalytic activity
neutrophil degranulation
negative regulation of protein localization to plasma membrane
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)
NM_022152
NM_001321427
NM_001321428
NM_001321429
NM_001321430

NM_001321432
NM_001321433
NM_001321435
NM_001321436
NM_001321438

NM_027154

RefSeq (bjelančevina)
NP_001308356
NP_001308357
NP_001308358
NP_001308359
NP_001308361

NP_001308362
NP_001308364
NP_001308365
NP_001308367
NP_071435

NP_081430

Lokacija (UCSC)Chr 2: 218.27 – 218.29 MbChr 1: 74.33 – 74.34 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Amiokiselininska sekvenca

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Dužina polipeptidnog lanca je 311 aminokiselina, a molekulska težina 34.607 Da.[7]

1020304050
MSNPSAPPPYEDRNPLYPGPPPPGGYGQPSVLPGGYPAYPGYPQPGYGHP
AGYPQPMPPTHPMPMNYGPGHGYDGEERAVSDSFGPGEWDDRKVRHTFIR
KVYSIISVQLLITVAIIAIFTFVEPVSAFVRRNVAVYYVSYAVFVVTYLI
LACCQGPRRRFPWNIILLTLFTFAMGFMTGTISSMYQTKAVIIAMIITAV
VSISVTIFCFQTKVDFTSCTGLFCVLGIVLLVTGIVTSIVLYFQYVYWLH
MLYAALGAICFTLFLAYDTQLVLGNRKHTISPEDYITGALQIYTDIIYIF
TFVLQLMGDRN

Reference

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000135926 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000006301 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc Natl Acad Sci U S A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  6. ^ "Entrez Gene: TMBIM1 transmembrane BAX inhibitor motif containing 1".
  7. ^ "UniProt, Q969X1" (jezik: engleski). Pristupljeno 20. 11. 2021.

Dopunska literatura

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