TARBP1
Vjerovatna metiltransferaza TARBP1 jest enzim koji je kod ljudi kodiran genom TARBP1 sa hromosoma 1.[5][6]
Aminokiselinska sekvenca
urediDužina polipeptidnog lanca je 1.621 aminokiselina, a molekulska težina 181. 675 Da.[7]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MEWVLAEALL | SQSRDPRALL | GALCQGEASA | ERVETLRFLL | QRLEDEEARG | ||||
| SGGAGALPEA | AREVAAGYLV | PLLRSLRGRP | AGGPDPSLQP | RHRRRVLRAA | ||||
| GAALRSCVRL | AGRPQLAAAL | AEEALRDLLA | GWRAPGAEAA | VEVLAAVGPC | ||||
| LRPREDGPLL | ERVAGTAVAL | ALGGGGDGDE | AGPAEDAAAL | VAGRLLPVLV | ||||
| QCGGAALRAV | WGGLAAPGAS | LGSGRVEEKL | LVLSALAEKL | LPEPGGDRAR | ||||
| GAREAGPDAR | RCWRFWRTVQ | AGLGQADALT | RKRARYLLQR | AVEVSAELGA | ||||
| DCTCGPQEGN | GPSLFWWSER | KKDELLKFWE | NYILIMETLE | GNQIHVIKPV | ||||
| LPKLNNLFEY | AVSEENGCWL | FHPSWHMCIY | KRMFESENKI | LSKEGVIHFL | ||||
| ELYETKILPF | SPEFSEFIIG | PLMDALSESS | LYSRSPGQPI | GSCSPLGLKL | ||||
| QKFLVTYISL | LPEEIKSSFL | LKFIRKMTSR | HWCAVPILFL | SKALANVPRH | ||||
| KALGIDGLLA | LRDVIHCTMI | THQILLRGAA | QCYLLQTAMN | LLDVEKVSLS | ||||
| DVSTFLMSLR | QEESLGRGTS | LWTELCDWLR | VNESYFKPSP | TCSSIGLHKT | ||||
| SLNAYVKSIV | QEYVKSSAWE | TGENCFMPDW | FEAKLVSLMV | LLAVDVEGMK | ||||
| TQYSGKQRTE | NVLRIFLDPL | LDVLMKFSTN | AYMPLLKTDR | CLQLLLKLLN | ||||
| TCRLKGSSAQ | DDEVSTVLQN | FFMSTTESIS | EFILRRLTMN | ELNSVSDLDR | ||||
| CHLYLMVLTE | LINLHLKVGW | KRGNPIWRVI | SLLKNASIQH | LQEMDSGQEP | ||||
| TVGSQIQRVV | SMAALAMVCE | AIDQKPELQL | DSLHAGPLES | FLSSLQLNQT | ||||
| LQKPHAEEQS | SYAHPLECSS | VLEESSSSQG | WGKIVAQYIH | DQWVCLSFLL | ||||
| KKYHTLIPTT | GSEILEPFLP | AVQMPIRTLQ | SALEALTVLS | SDQVLPVFHC | ||||
| LKVLVPKLLT | SSESLCIESF | DMAWKIISSL | SNTQLIFWAN | LKAFVQFVFD | ||||
| NKVLTIAAKI | KGQAYFKIKE | IMYKIIEMSA | IKTGVFNTLI | SYCCQSWIVS | ||||
| ASNVSQGSLS | SAKNYSELIL | EACIFGTVFR | RDQRLVQDVQ | TFIENLGHDC | ||||
| AANIVMENTK | REDHYVRICA | VKFLCLLDGS | NMSHKLFIED | LAIKLLDKDE | ||||
| LVSKSKKRYY | VNSLQHRVKN | RVWQTLLVLF | PRLDQNFLNG | IIDRIFQAGF | ||||
| TNNQASIKYF | IEWIIILILH | KFPQFLPKFW | DCFSYGEENL | KTSICTFLAV | ||||
| LSHLDIITQN | IPEKKLILKQ | ALIVVLQWCF | NHNFSVRLYA | LVALKKLWTV | ||||
| CKVLSVEEFD | ALTPVIESSL | HQVESMHGAG | NAKKNWQRIQ | EHFFFATFHP | ||||
| LKDYCLETIF | YILPRLSGLI | EDEWITIDKF | TRFTDVPLAA | GFQWYLSQTQ | ||||
| LSKLKPGDWS | QQDIGTNLVE | ADNQAEWTDV | QKKIIPWNSR | VSDLDLELLF | ||||
| QDRAARLGKS | ISRLIVVASL | IDKPTNLGGL | CRTCEVFGAS | VLVVGSLQCI | ||||
| SDKQFQHLSV | SAEQWLPLVE | VKPPQLIDYL | QQKKTEGYTI | IGVEQTAKSL | ||||
| DLTQYCFPEK | SLLLLGNERE | GIPANLIQQL | DVCVEIPQQG | IIRSLNVHVS | ||||
| GALLIWEYTR | QQLLSHGDTK | P |
Funkcija
urediOvaj gen povezuje se sa HIV-1, uzročnikom sindroma stečene imunodeficijencije (AIDS), koji sadrži genomsku RNK i proizvodi hromosomski integriranu DNK tokom replikativnog ciklusa. Aktivacija ekspresije HIV-1 gena pomoću transaktivatora Tata ovisi od regulatornog elementa RNK (TAR) koji se nalazi nizvodno od mesta inicijacije transkripcije. Ovaj element formira stabilnu strukturu matične petlje i može biti vezan ili za protein koji kodira ovaj gen ili za RNK-polimerazu II. Ovaj protein može djelovati na odvajanje RNK-polimeraze II od TAR-a tokom transkripcionog elongacije. Alternativno prerađene varijante transkripta ovog gena mogu postojati, ali priroda njihove pune dužine nije utvrđena.[6]
Reference
uredi- ^ a b c GRCh38: Ensembl release 89: ENSG00000059588 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000090290 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Wu F, Garcia J, Sigman D, Gaynor R (Dec 1991). "tat regulates binding of the human immunodeficiency virus trans-activating region RNA loop-binding protein TRP-185". Genes Dev. 5 (11): 2128–40. doi:10.1101/gad.5.11.2128. PMID 1936997.
- ^ a b "Entrez Gene: TARBP1 Tar (HIV-1) RNA binding protein 1".
- ^ "UniProt, Q13395" (jezik: engleski). Pristupljeno 20. 12. 2021.
Dopunska literatura
uredi- Sheline CT, Milocco LH, Jones KA (1992). "Two distinct nuclear transcription factors recognize loop and bulge residues of the HIV-1 TAR RNA hairpin". Genes Dev. 5 (12B): 2508–20. doi:10.1101/gad.5.12b.2508. PMID 1752441.
- Wu-Baer F, Sigman D, Gaynor RB (1995). "Specific binding of RNA polymerase II to the human immunodeficiency virus trans-activating region RNA is regulated by cellular cofactors and Tat". Proc. Natl. Acad. Sci. U.S.A. 92 (16): 7153–7. Bibcode:1995PNAS...92.7153W. doi:10.1073/pnas.92.16.7153. PMC 41297. PMID 7638159.
- Wu-Baer F, Lane WS, Gaynor RB (1996). "Identification of a group of cellular cofactors that stimulate the binding of RNA polymerase II and TRP-185 to human immunodeficiency virus 1 TAR RNA". J. Biol. Chem. 271 (8): 4201–8. doi:10.1074/jbc.271.8.4201. PMID 8626763.
- Wu-Baer F, Lane WS, Gaynor RB (1996). "The cellular factor TRP-185 regulates RNA polymerase II binding to HIV-1 TAR RNA". EMBO J. 14 (23): 5995–6009. doi:10.1002/j.1460-2075.1995.tb00288.x. PMC 394719. PMID 8846792.
- Yedavalli VS, Benkirane M, Jeang KT (2003). "Tat and trans-activation-responsive (TAR) RNA-independent induction of HIV-1 long terminal repeat by human and murine cyclin T1 requires Sp1". J. Biol. Chem. 278 (8): 6404–10. doi:10.1074/jbc.M209162200. PMID 12458222.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.