Alfa-N-acetilgalaktozaminid alfa-2,6-sijaliltransferaza 6 je enzim koji je kod ljudi kodiran genom ST6GALNAC6.[5][6]

ST6GALNAC6
Identifikatori
AliasiST6GALNAC6
Vanjski ID-jeviOMIM: 610135 MGI: 1355316 HomoloGene: 8390 GeneCards: ST6GALNAC6
Lokacija gena (čovjek)
Hromosom 9 (čovjek)
Hrom.Hromosom 9 (čovjek)[1]
Hromosom 9 (čovjek)
Genomska lokacija za ST6GALNAC6
Genomska lokacija za ST6GALNAC6
Bend9q34.11Početak127,885,321 bp[1]
Kraj127,905,408 bp[1]
Lokacija gena (miš)
Hromosom 2 (miš)
Hrom.Hromosom 2 (miš)[2]
Hromosom 2 (miš)
Genomska lokacija za ST6GALNAC6
Genomska lokacija za ST6GALNAC6
Bend2|2 BPočetak32,489,721 bp[2]
Kraj32,510,818 bp[2]
Ontologija gena
Molekularna funkcija aktivnost sa transferazom
glycosyltransferase activity
sialyltransferase activity
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity
Ćelijska komponenta integral component of membrane
Golđijev aparat
membrana
ćelijska membrana
Golđijeva membrana
citoplazma
Biološki proces cell-cell recognition
glycoprotein metabolic process
glycosphingolipid metabolic process
GO:0033578, GO:0033577, GO:0033575, GO:0033576 protein glycosylation
glycosylceramide metabolic process
oligosaccharide metabolic process
sialylation
protein N-linked glycosylation via asparagine
ganglioside biosynthetic process
oligosaccharide biosynthetic process
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)
NM_001286999
NM_001287000
NM_001287001
NM_001287002
NM_001287003

NM_013443
NM_001388489

NM_001025310
NM_001025311
NM_001289547
NM_001289548
NM_001289549

NM_016973

RefSeq (bjelančevina)
NP_001273928
NP_001273929
NP_001273930
NP_001273931
NP_001273932

NP_038471

NP_001020481
NP_001020482
NP_001276476
NP_001276477
NP_001276478

NP_058669

Lokacija (UCSC)Chr 9: 127.89 – 127.91 MbChr 2: 32.49 – 32.51 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Aminokiselinska sekvenca

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Dužina polipeptidnog lanca je 333 aminokiseline, а molekulska težina 38.068 Da.[7]

1020304050
MACSRPPSQCEPTSLPPGPPAGRRHLPLSRRRREMSSNKEQRSAVFVILF
ALITILILYSSNSANEVFHYGSLRGRSRRPVNLKKWSITDGYVPILGNKT
LPSRCHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNK
TTYRVVAHSSVFRVLRRPQEFVNRTPETVFIFWGPPSKMQKPQGSLVRVI
QRAGLVFPNMEAYAVSPGRMRQFDDLFRGETGKDREKSHSWLSTGWFTMV
IAVELCDHVHVYGMVPPNYCSQRPRLQRMPYHYYEPKGPDECVTYIQNEH
SRKGNHHRFITEKRVFSSWAQLYGITFSHPSWT

Reference

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000160408 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026811 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Tsuchida A, Okajima T, Furukawa K, Ando T, Ishida H, Yoshida A, Nakamura Y, Kannagi R, Kiso M, Furukawa K (Jun 2003). "Synthesis of disialyl Lewis a (Le(a)) structure in colon cancer cell lines by a sialyltransferase, ST6GalNAc VI, responsible for the synthesis of alpha-series gangliosides". J Biol Chem. 278 (25): 22787–94. doi:10.1074/jbc.M211034200. PMID 12668675.
  6. ^ "Entrez Gene: ST6GALNAC6 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6".
  7. ^ "UniProt, Q969X2". Pristupljeno 12. 9. 2021.

Dopunska literatura

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