Sfingozin-1-fosfat lijaza 1 je enzim koji je kod ljudi kodiran genom SGPL1.[5][6][7]

SGPL1
Dostupne strukture
PDBPretraga ortologa: PDBe RCSB
Spisak PDB ID kodova

4Q6R

Identifikatori
AliasiSGPL1
Vanjski ID-jeviOMIM: 603729 MGI: 1261415 HomoloGene: 2897 GeneCards: SGPL1
Lokacija gena (čovjek)
Hromosom 10 (čovjek)
Hrom.Hromosom 10 (čovjek)[1]
Hromosom 10 (čovjek)
Genomska lokacija za SGPL1
Genomska lokacija za SGPL1
Bend10q22.1Početak70,815,948 bp[1]
Kraj70,881,184 bp[1]
Lokacija gena (miš)
Hromosom 10 (miš)
Hrom.Hromosom 10 (miš)[2]
Hromosom 10 (miš)
Genomska lokacija za SGPL1
Genomska lokacija za SGPL1
Bend10 B4|10 32.14 cMPočetak60,934,421 bp[2]
Kraj60,983,482 bp[2]
Obrazac RNK ekspresije




Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija GO:0001948, GO:0016582 vezivanje za proteine
catalytic activity
lyase activity
pyridoxal phosphate binding
carboxy-lyase activity
sphinganine-1-phosphate aldolase activity
Ćelijska komponenta integral component of membrane
endoplasmic reticulum membrane
membrana
integral component of endoplasmic reticulum membrane
Endoplazmatski retikulum
Biološki proces fibroblast migration
roof of mouth development
luteinization
Leydig cell differentiation
estrogen metabolic process
androgen metabolic process
Nefrogeneza
ceramide metabolic process
regulation of multicellular organism growth
lipid metabolism
carboxylic acid metabolic process
skeletal system morphogenesis
sphingolipid biosynthetic process
post-embryonic development
fatty acid metabolic process
female gonad development
Vaskulogeneza
nitrogen compound metabolic process
Spermatogeneza
apoptotic signaling pathway
platelet-derived growth factor receptor signaling pathway
face morphogenesis
GO:0097285 apoptoza
sphingolipid metabolic process
sphingolipid catabolic process
Hematopoeza
ameboidal-type cell migration
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_003901

NM_009163
NM_001316673
NM_001316674

RefSeq (bjelančevina)

NP_003892

NP_001303602
NP_001303603
NP_033189

Lokacija (UCSC)Chr 10: 70.82 – 70.88 MbChr 10: 60.93 – 60.98 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Aminokiselinska sekvenca

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Dužina polipeptidnog lanca je 568 aminokiselina, а molekulska težina 63.524 Da.[8]

1020304050
MPSTDLLMLKAFEPYLEILEVYSTKAKNYVNGHCTKYEPWQLIAWSVVWT
LLIVWGYEFVFQPESLWSRFKKKCFKLTRKMPIIGRKIQDKLNKTKDDIS
KNMSFLKVDKEYVKALPSQGLSSSAVLEKLKEYSSMDAFWQEGRASGTVY
SGEEKLTELLVKAYGDFAWSNPLHPDIFPGLRKIEAEIVRIACSLFNGGP
DSCGCVTSGGTESILMACKAYRDLAFEKGIKTPEIVAPQSAHAAFNKAAS
YFGMKIVRVPLTKMMEVDVRAMRRAISRNTAMLVCSTPQFPHGVIDPVPE
VAKLAVKYKIPLHVDACLGGFLIVFMEKAGYPLEHPFDFRVKGVTSISAD
THKYGYAPKGSSLVLYSDKKYRNYQFFVDTDWQGGIYASPTIAGSRPGGI
SAACWAALMHFGENGYVEATKQIIKTARFLKSELENIKGIFVFGNPQLSV
IALGSRDFDIYRLSNLMTAKGWNLNQLQFPPSIHFCITLLHARKRVAIQF
LKDIRESVTQIMKNPKAKTTGMGAIYGMAQTTVDRNMVAELSSVFLDSLY
STDTVTQGSQMNGSPKPH

Reference

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000166224 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020097 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Zhou J, Saba JD (Mar 1998). "Identification of the first mammalian sphingosine phosphate lyase gene and its functional expression in yeast". Biochem Biophys Res Commun. 242 (3): 502–7. doi:10.1006/bbrc.1997.7993. PMID 9464245.
  6. ^ Oskouian B, Sooriyakumaran P, Borowsky AD, Crans A, Dillard-Telm L, Tam YY, Bandhuvula P, Saba JD (Nov 2006). "Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is down-regulated in colon cancer". Proc Natl Acad Sci U S A. 103 (46): 17384–9. doi:10.1073/pnas.0600050103. PMC 1859938. PMID 17090686.
  7. ^ "Entrez Gene: SGPL1 sphingosine-1-phosphate lyase 1".
  8. ^ "UniProt, O95470". Pristupljeno 4. 9. 2021.

Dopunska literatuara

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Vanjski linkovi

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