SEC24D

Proteinski transportni protein Sec24D jest protein koji je kod ljudi kodiran genom SEC24D sa hromosoma 4.

SEC24D
Dostupne strukture PDB Pretraga Human UniProta: PDBe RCSB Spisak PDB ID kodova 3EFO, 3EG9
Identifikatori
Aliasi	SEC24D
Vanjski ID-jevi	OMIM: 607186 MGI: 1916858 HomoloGene: 40986 GeneCards: SEC24D
Lokacija gena (čovjek) Hrom. Hromosom 4 (čovjek) Bend 4q26 Početak 118,722,823 bp Kraj 118,838,683 bp
Lokacija gena (miš) Hrom. Hromosom 3 (miš) Bend 3|3 G1 Početak 123,061,104 bp Kraj 123,159,290 bp
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • GO:0001948, GO:0016582 vezivanje za proteine • SNARE binding • vezivanje iona cinka • vezivanje iona metala Ćelijska komponenta • citoplazma • endoplasmic reticulum membrane • membrana • Golđijeva membrana • Endoplazmatski retikulum • COPII vesicle coat • citosol • ER to Golgi transport vesicle membrane • GO:0016023 citoplazmatska vezikula Biološki proces • antigen processing and presentation of exogenous peptide antigen via MHC class II • antigen processing and presentation of peptide antigen via MHC class I • in utero embryonic development • COPII vesicle coating • protein transport • intracellular protein transport • vesicle-mediated transport • endoplasmic reticulum to Golgi vesicle-mediated transport • COPII-coated vesicle cargo loading Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	9871	69608
Ensembl	ENSG00000150961	ENSMUSG00000039234
UniProt	O94855	n/a
RefSeq (mRNK)	NM_014822 NM_001318066	NM_027135
RefSeq (bjelančevina)	NP_001304995 NP_055637	n/a
Lokacija (UCSC)	Chr 4: 118.72 – 118.84 Mb	Chr 3: 123.06 – 123.16 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 1.032 aminokiseline, а molekulska težina 113.010 Da.

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MSQQGYVATP		PYSQPQPGIG		LSPPHYGHYG		DPSHTASPTG		MMKPAGPLGA
TATRGMLPPG		PPPPGPHQFG		QNGAHATGHP		PQRFPGPPPV		NNVASSHAPY
QPSAQSSYPG		PISTSSVTQL		GSQLSAMQIN		SYGSGMAPPS		QGPPGPLSAT
SLQTPPRPPQ		PSILQPGSQV		LPPPPTTLNG		PGASPLPLPM		YRPDGLSGPP
PPNAQYQPPP		LPGQTLGAGY		PPQQANSGPQ		MAGAQLSYPG		GFPGGPAQMA
GPPQPQKKLD		PDSIPSPIQV		IENDRASRGG		QVYATNTRGQ		IPPLVTTDCM
IQDQGNASPR		FIRCTTYCFP		CTSDMAKQAQ		IPLAAVIKPF		ATIPSNESPL
YLVNHGESGP		VRCNRCKAYM		CPFMQFIEGG		RRYQCGFCNC		VNDVPPFYFQ
HLDHIGRRLD		HYEKPELSLG		SYEYVATLDY		CRKSKPPNPP		AFIFMIDVSY
SNIKNGLVKL		ICEELKTMLE		KIPKEEQEET		SAIRVGFITY		NKVLHFFNVK
SNLAQPQMMV		VTDVGEVFVP		LLDGFLVNYQ		ESQSVIHNLL		DQIPDMFADS
NENETVFAPV		IQAGMEALKA		ADCPGKLFIF		HSSLPTAEAP		GKLKNRDDKK
LVNTDKEKIL		FQPQTNVYDS		LAKDCVAHGC		SVTLFLFPSQ		YVDVASLGLV
PQLTGGTLYK		YNNFQMHLDR		QQFLNDLRND		IEKKIGFDAI		MRVRTSTGFR
ATDFFGGILM		NNTTDVEMAA		IDCDKAVTVE		FKHDDKLSED		SGALIQCAVL
YTTISGQRRL		RIHNLGLNCS		SQLADLYKSC		ETDALINFFA		KSAFKAVLHQ
PLKVIREILV		NQTAHMLACY		RKNCASPSAA		SQLILPDSMK		VLPVYMNCLL
KNCVLLSRPE		ISTDERAYQR		QLVMTMGVAD		SQLFFYPQLL		PIHTLDVKST
MLPAAVRCSE		SRLSEEGIFL		LANGLHMFLW		LGVSSPPELI		QGIFNVPSFA
HINTDMTLLP		EVGNPYSQQL		RMIMGIIQQK		RPYSMKLTIV		KQREQPEMVF
RQFLVEDKGL		YGGSSYVDFL		CCVHKEICQL		LN

Funkcija

Protein kodiran ovim genom je član potporodice SEC24 porodice SEC23/SEC24, koja je uključena u promet vezikula. Kodirani protein je sličan kvaščevoj Sec24p komponenti COPII. COPII je proteinski kompleks omotača, odgovoran za pupanje vezikula iz ER. Uloga ovog genskog proizvoda je implicirana u oblikovanju vezikula, kao i u selekciji i koncentraciji tereta.

Dopunska literatura

• Tang BL, Kausalya J, Low DY, et al. (1999). "A family of mammalian proteins homologous to yeast Sec24p". Biochem. Biophys. Res. Commun. 258 (3): 679–84. doi:10.1006/bbrc.1999.0574. PMID 10329445.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Watson P, Forster R, Palmer KJ, et al. (2005). "Coupling of ER exit to microtubules through direct interaction of COPII with dynactin". Nat. Cell Biol. 7 (1): 48–55. doi:10.1038/ncb1206. PMC 1592520. PMID 15580264.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Farhan H, Reiterer V, Korkhov VM, et al. (2007). "Concentrative export from the endoplasmic reticulum of the gamma-aminobutyric acid transporter 1 requires binding to SEC24D". J. Biol. Chem. 282 (10): 7679–89. doi:10.1074/jbc.M609720200. PMID 17210573.