Aminokiselinska sekvenca
uredi
Dužina polipeptidnog lanca je 347 aminokiselina , a molekulska težina 38.287 Da .[ 8]
10 20 30 40 50 MAQSRDGGNP FAEPSELDNP FQDPAVIQHR PSRQYATLDV YNPFETREPP PAYEPPAPAP LPPPSAPSLQ PSRKLSPTEP KNYGSYSTQA SAAAATAELL KKQEELNRKA EELDRREREL QHAALGGTAT RQNNWPPLPS FCPVQPCFFQ DISMEIPQEF QKTVSTMYYL WMCSTLALLL NFLACLASFC VETNNGAGFG LSILWVLLFT PCSFVCWYRP MYKAFRSDSS FNFFVFFFIF FVQDVLFVLQ AIGIPGWGFS GWISALVVPK GNTAVSVLML LVALLFTGIA VLGIVMLKRI HSLYRRTGAS FQKAQQEFAA GVFSNPAVRT AAANAAAGAA ENAFRAP
Ovaj genski proizvod pripada SCAMP porodici proteina koji su membranski proteini sekretornih nosača. Funkcioniraju kao nosači na površini ćelije u putevima reciklaže poslije obrade u Golgijevom aparatu . Različiti članovi porodice su visoko srodni proizvodima različitih gena i obično se eksprimiraju zajedno. Ovi nalazi sugeriraju da SCAMP-ovi mogu funkcionirati na istom mjestu tokom transporta vezikula , a ne u različitim putevima. Za ovaj gen su pronađene dvije varijante transkripta koje kodiraju različite izoforme .[ 7]
^ a b c ENSG00000116521 GRCh38: Ensembl release 89: ENSG00000263290, ENSG00000116521 - Ensembl , maj 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028049 - Ensembl , maj 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Winfield SL, Tayebi N, Martin BM, Ginns EI, Sidransky E (oktobar 1997). "Identification of three additional genes contiguous to the glucocerebrosidase locus on chromosome 1q21: implications for Gaucher disease" . Genome Research . 7 (10): 1020–6. doi :10.1101/gr.7.10.1020 . PMC 310674 PMID 9331372 . ^ Wu TT, Castle JD (juli 1998). "Tyrosine phosphorylation of selected secretory carrier membrane proteins, SCAMP1 and SCAMP3, and association with the EGF receptor" . Molecular Biology of the Cell . 9 (7): 1661–74. doi :10.1091/mbc.9.7.1661 . PMC 25404 PMID 9658162 . ^ a b "Entrez Gene: SCAMP3 secretory carrier membrane protein 3" .^ "UniProt, O14828" (jezik: engleski). Pristupljeno 18. 12. 2021 .^ Aoh QL, Castle AM, Hubbard CH, Katsumata O, Castle JD (mart 2009). "SCAMP3 negatively regulates epidermal growth factor receptor degradation and promotes receptor recycling" . Molecular Biology of the Cell . 20 (6): 1816–32. doi :10.1091/mbc.E08-09-0894 . PMC 2655259 PMID 19158374 .
Dopunska literatura
uredi
Wu TT, Castle JD (juli 1997). "Evidence for colocalization and interaction between 37 and 39 kDa isoforms of secretory carrier membrane proteins (SCAMPs)". Journal of Cell Science . 110 ( Pt 13) (13): 1533–41. PMID 9224770 . Singleton DR, Wu TT, Castle JD (septembar 1997). "Three mammalian SCAMPs (secretory carrier membrane proteins) are highly related products of distinct genes having similar subcellular distributions". Journal of Cell Science . 110 ( Pt 17) (17): 2099–107. PMID 9378760 . Fernández-Chacón R, Achiriloaie M, Janz R, Albanesi JP, Südhof TC (april 2000). "SCAMP1 function in endocytosis" . The Journal of Biological Chemistry . 275 (17): 12752–6. doi :10.1074/jbc.275.17.12752 PMID 10777571 . Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC (maj 2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Analytical Chemistry . 76 (10): 2763–72. doi :10.1021/ac035352d . PMID 15144186 . Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ (januar 2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells" . Nature Biotechnology . 23 (1): 94–101. doi :10.1038/nbt1046 . PMID 15592455 . S2CID 7200157 . Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (novembar 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" . Cell . 127 (3): 635–48. doi :10.1016/j.cell.2006.09.026 PMID 17081983 . S2CID 7827573 .
