SPATS2-liki protein (spermatogenezi pridruženi, serin-bogati 2-liki protein) ili DNAPTP6 (DNK-polimerazno transaktivirtani protein 6) jest protein koji je kod ljudi kodiran genom SPATS2L sa hromosoma 2..[5][6]

SATB2
Dostupne strukture
PDBPretraga ortologa: PDBe RCSB
Spisak PDB ID kodova

1WI3, 1WIZ, 2CSF

Identifikatori
AliasiSATB2
Vanjski ID-jeviOMIM: 608148 MGI: 2679336 HomoloGene: 32249 GeneCards: SATB2
Lokacija gena (čovjek)
Hromosom 2 (čovjek)
Hrom.Hromosom 2 (čovjek)[1]
Hromosom 2 (čovjek)
Genomska lokacija za SATB2
Genomska lokacija za SATB2
Bend2q33.1Početak199,269,500 bp[1]
Kraj199,471,266 bp[1]
Lokacija gena (miš)
Hromosom 1 (miš)
Hrom.Hromosom 1 (miš)[2]
Hromosom 1 (miš)
Genomska lokacija za SATB2
Genomska lokacija za SATB2
Bend1|1 C1.3Početak56,833,140 bp[2]
Kraj57,017,809 bp[2]
Ontologija gena
Molekularna funkcija sequence-specific DNA binding
vezivanje sa DNK
chromatin binding
GO:0001948, GO:0016582 vezivanje za proteine
GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific
RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific
Ćelijska komponenta histone deacetylase complex
transcription regulator complex
nuclear matrix
jedro
nukleoplazma
Biološki proces commitment of neuronal cell to specific neuron type in forebrain
embryonic skeletal system morphogenesis
cellular response to organic substance
chromatin remodeling
roof of mouth development
GO:0009373 regulation of transcription, DNA-templated
embryonic pattern specification
GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II
neuron migration
GO:1901227 negative regulation of transcription by RNA polymerase II
transcription, DNA-templated
multicellular organism development
cartilage development
Regulacija ekspresije gena
osteoblast development
GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II
transcription by RNA polymerase II
GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_001172509
NM_001172517
NM_015265

NM_139146
NM_001358580
NM_001358581

RefSeq (bjelančevina)

NP_001165980
NP_001165988
NP_056080

NP_631885
NP_001345509
NP_001345510

Lokacija (UCSC)Chr 2: 199.27 – 199.47 MbChr 1: 56.83 – 57.02 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Aminokiselinska sekvenca

uredi

Dužina polipeptidnog lanca je 558 aminokiselina, a molekulska težina 6 729 Da.[7]

1020304050
MAELNTHVNVKEKIYAVRSVVPNKSNNEIVLVLQQFDFNVDKAVQAFVDG
SAIQVLKEWNMTGKKKNNKRKRSKSKQHQGNKDAKDKVERPEAGPLQPQP
PQIQNGPMNGCEKDSSSTDSANEKPALIPREKKISILEEPSKALRGVTEG
NRLLQQKLSLDGNPKPIHGTTERSDGLQWSAEQPCNPSKPKAKTSPVKSN
TPAAHLEIKPDELAKKRGPNIEKSVKDLQRCTVSLTRYRVMIKEEVDSSV
KKIKAAFAELHNCIIDKEVSLMAEMDKVKEEAMEILTARQKKAEELKRLT
DLASQMAEMQLAELRAEIKHFVSERKYDEELGKAARFSCDIEQLKAQIML
CGEITHPKNNYSSRTPCSSLLPLLNAHAATSGKQSNFSRKSSTHNKPSEG
KAANPKMVSSLPSTADPSHQTMPANKQNGSSNQRRRFNPQYHNNRLNGPA
KSQGSGNEAEPLGKGNSRHEHRRQPHNGFRPKNKGGAKNQEASLGMKTPE
APAHSEKPRRRQHAADTSEARPFRGSVGRVSQCNLCPTRIEVSTDAAVLS
VPAVTLVA

Reference

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000119042 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038331 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  6. ^ "Entrez Gene: DNAPTP6 DNA polymerase-transactivated protein 6".
  7. ^ "UniProt, Q9NUQ6" (jezik: engleski). Pristupljeno 19. 11. 2012.

Dopunska literatura

uredi