RBM15

RBM15
Identifikatori
Aliasi	RBM15
Vanjski ID-jevi	OMIM: 606077 MGI: 2443205 HomoloGene: 23383 GeneCards: RBM15
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	110,346,681 bp
Lokacija gena (miš)
Hrom.	Hromosom 3 (miš)
Kraj	107,240,989 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • nucleic acid binding; • vezivanje sa RNK; • mRNA binding;
Ćelijska komponenta	• nuclear speck; • Jedarna membrana; • membrana; • jedro; • nukleoplazma; • nuclear envelope; • RNA N6-methyladenosine methyltransferase complex;
Biološki proces	• branching involved in blood vessel morphogenesis; • ventricular septum morphogenesis; • mRNA splicing, via spliceosome; • placenta blood vessel development; • GO:0022415 viral process; • negative regulation of myeloid cell differentiation; • spleen development; • GO:0045996 negative regulation of transcription, DNA-templated; • positive regulation of transcription of Notch receptor target; • regulation of alternative mRNA splicing, via spliceosome; • RNA methylation; • dosage compensation by inactivation of X chromosome; • thrombopoietin-mediated signaling pathway; • regulation of megakaryocyte differentiation;
	Izvori:Amigo / QuickGO
Ortolozi
	64783
	229700
	ENSG00000162775
	ENSMUSG00000048109
	Q96T37
	Q0VBL3
	NM_001201545; NM_022768; NM_014092
	NM_001045807
	NP_001188474; NP_073605
	NP_001039272
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Pretpostavljeni RNK-vezujući protein 15 jest protein koji je kod ljudi kodiran genom RBM15 sa hromosoma 1.^[5]^[6]^[7]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 977 aminokiselina, a molekulska težina 107.189 Da.^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MRTAGRDPVP	RRSPRWRRAV	PLCETSAGRR	VTQLRGDDLR	RPATMKGKER
SPVKAKRSRG	GEDSTSRGER	SKKLGGSGGS	NGSSSGKTDS	GGGSRRSLHL
DKSSSRGGSR	EYDTGGGSSS	SRLHSYSSPS	TKNSSGGGES	RSSSRGGGGE
SRSSGAASSA	PGGGDGAEYK	TLKISELGSQ	LSDEAVEDGL	FHEFKRFGDV
SVKISHLSGS	GSGDERVAFV	NFRRPEDARA	AKHARGRLVL	YDRPLKIEAV
YVSRRRSRSP	LDKDTYPPSA	SVVGASVGGH	RHPPGGGGGQ	RSLSPGGAAL
GYRDYRLQQL	ALGRLPPPPP	PPLPRDLERE	RDYPFYERVR	PAYSLEPRVG
AGAGAAPFRE	VDEISPEDDQ	RANRTLFLGN	LDITVTESDL	RRAFDRFGVI
TEVDIKRPSR	GQTSTYGFLK	FENLDMSHRA	KLAMSGKIII	RNPIKIGYGK
ATPTTRLWVG	GLGPWVPLAA	LAREFDRFGT	IRTIDYRKGD	SWAYIQYESL
DAAHAAWTHM	RGFPLGGPDR	RLRVDFADTE	HRYQQQYLQP	LPLTHYELVT
DAFGHRAPDP	LRGARDRTPP	LLYRDRDRDL	YPDSDWVPPP	PPVRERSTRT
AATSVPAYEP	LDSLDRRRDG	WSLDRDRGDR	DLPSSRDQPR	KRRLPEESGG
RHLDRSPESD	RPRKRHCAPS	PDRSPELSSS	RDRYNSDNDR	SSRLLLERPS
PIRDRRGSLE	KSQGDKRDRK	NSASAERDRK	HRTTAPTEGK	SPLKKEDRSD
GSAPSTSTAS	SKLKSPSQKQ	DGGTAPVASA	SPKLCLAWQG	MLLLKNSNFP
SNMHLLQGDL	QVASSLLVEG	STGGKVAQLK	ITQRLRLDQP	KLDEVTRRIK
VAGPNGYAIL	LAVPGSSDSR	SSSSSAASDT	ATSTQRPLRN	LVSYLKQKQA
AGVISLPVGG	NKDKENTGVL	HAFPPCEFSQ	QFLDSPAKAL	AKSEEDYLVM
IIVRGFGFQI	GVRYENKKRE	NLALTLL

Funkcija

Putativvni RNK-vezujući protein 15 je RNK-vezujući protein koji djeluje kao ključni regulator metilacije N6-metiladenozinske (m⁶A) RNK.^[9]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000162775 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000048109 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ma Z, Morris SW, Valentine V, Li M, Herbrick JA, Cui X, Bouman D, Li Y, Mehta PK, Nizetic D, Kaneko Y, Chan GC, Chan LC, Squire J, Scherer SW, Hitzler JK (Jun 2001). "Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia". Nat Genet. 28 (3): 220–1. doi:10.1038/90054. PMID 11431691. S2CID 36236342.
^ Mercher T, Coniat MB, Monni R, Mauchauffe M, Nguyen Khac F, Gressin L, Mugneret F, Leblanc T, Dastugue N, Berger R, Bernard OA (maj 2001). "Involvement of a human gene related to the Drosophila spen gene in the recurrent t(1;22) translocation of acute megakaryocytic leukemia". Proc Natl Acad Sci U S A. 98 (10): 5776–9. Bibcode:2001PNAS...98.5776M. doi:10.1073/pnas.101001498. PMC 33289. PMID 11344311.
^ "Entrez Gene: RBM15 RNA binding motif protein 15".
^ "UniProt, Q96T37" (jezik: eng.). Pristupljeno 4. 12. 2021.CS1 održavanje: nepoznati jezik (link)
^ "UniProtKB - Q96T37 (RBM15_HUMAN)". Pristupljeno 29. 10. 2018.

Dopunska literatura

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Hsiao HH, Yang MY, Liu YC, et al. (2005). "RBM15-MKL1 (OTT-MAL) fusion transcript in an adult acute myeloid leukemia patient". Am. J. Hematol. 79 (1): 43–5. doi:10.1002/ajh.20298. PMID 15849773. S2CID 30859557.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Lindtner S, Zolotukhin AS, Uranishi H, et al. (2007). "RNA-binding motif protein 15 binds to the RNA transport element RTE and provides a direct link to the NXF1 export pathway". J. Biol. Chem. 281 (48): 36915–28. doi:10.1074/jbc.M608745200. PMID 17001072.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000162775 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000048109 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11431691-5] Ma Z, Morris SW, Valentine V, Li M, Herbrick JA, Cui X, Bouman D, Li Y, Mehta PK, Nizetic D, Kaneko Y, Chan GC, Chan LC, Squire J, Scherer SW, Hitzler JK (Jun 2001). "Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia". Nat Genet. 28 (3): 220–1. doi:10.1038/90054. PMID 11431691. S2CID 36236342.

[pmid11344311-6] Mercher T, Coniat MB, Monni R, Mauchauffe M, Nguyen Khac F, Gressin L, Mugneret F, Leblanc T, Dastugue N, Berger R, Bernard OA (maj 2001). "Involvement of a human gene related to the Drosophila spen gene in the recurrent t(1;22) translocation of acute megakaryocytic leukemia". Proc Natl Acad Sci U S A. 98 (10): 5776–9. Bibcode:2001PNAS...98.5776M. doi:10.1073/pnas.101001498. PMC 33289. PMID 11344311.

[entrez-7] "Entrez Gene: RBM15 RNA binding motif protein 15".

[UniProt-8] "UniProt, Q96T37" (jezik: eng.). Pristupljeno 4. 12. 2021.CS1 održavanje: nepoznati jezik (link)

[uniprot-9] "UniProtKB - Q96T37 (RBM15_HUMAN)". Pristupljeno 29. 10. 2018.

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