OVGP1
Jajovodno-specifični glikoprotein , znan i kao jajovodni glikoprotein (OGP) ili estrogen-ovisni jajovodni protein (EGP) ili mucin-9 (MUC9) jest protein koji je kod ljudi kodiran genom OVGP1 sa hromosoma 1.[5][6][7]
Aminokiselinska sekvenca
urediDužina polipeptidnog lanca je 678 aminokiselina, a molekulska težina 75.421 Da.[8]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MWKLLLWVGL | VLVLKHHDGA | AHKLVCYFTN | WAHSRPGPAS | ILPHDLDPFL | ||||
| CTHLIFAFAS | MNNNQIVAKD | LQDEKILYPE | FNKLKERNRE | LKTLLSIGGW | ||||
| NFGTSRFTTM | LSTFANREKF | IASVISLLRT | HDFDGLDLFF | LYPGLRGSPM | ||||
| HDRWTFLFLI | EELLFAFRKE | ALLTMRPRLL | LSAAVSGVPH | IVQTSYDVRF | ||||
| LGRLLDFINV | LSYDLHGSWE | RFTGHNSPLF | SLPEDPKSSA | YAMNYWRKLG | ||||
| APSEKLIMGI | PTYGRTFRLL | KASKNGLQAR | AIGPASPGKY | TKQEGFLAYF | ||||
| EICSFVWGAK | KHWIDYQYVP | YANKGKEWVG | YDNAISFSYK | AWFIRREHFG | ||||
| GAMVWTLDMD | DVRGTFCGTG | PFPLVYVLND | ILVRAEFSST | SLPQFWLSSA | ||||
| VNSSSTDPER | LAVTTAWTTD | SKILPPGGEA | GVTEIHGKCE | NMTITPRGTT | ||||
| VTPTKETVSL | GKHTVALGEK | TEITGAMTMT | SVGHQSMTPG | EKALTPVGHQ | ||||
| SVTTGQKTLT | SVGYQSVTPG | EKTLTPVGHQ | SVTPVSHQSV | SPGGTTMTPV | ||||
| HFQTETLRQN | TVAPRRKAVA | REKVTVPSRN | ISVTPEGQTM | PLRGENLTSE | ||||
| VGTHPRMGNL | GLQMEAENRM | MLSSSPVIQL | PEQTPLAFDN | RFVPIYGNHS | ||||
| SVNSVTPQTS | PLSLKKEIPE | NSAVDEEA |
Funkcija
urediGlikoprotein specifičan za jajovode je veliki, bogat ugljikohidratima, epitelni glikoprotein sa brojnim O-glikozilacijskim mjestima unutar treoninom, serinom i prolinom bogatih tandemskih ponavlja. Gen je sličan članovima porodice sluznih gena i glikozil hidrolaze 18. Regulacija ekspresije može biti estrogen-ovisna. Ekspresija gena i sekrecija proteina javljaju se tokom kasnog razvoja folikula u ranoj fazi embriogeneze. Protein se luči iz epitelnih ćelija ovidukt a bez cilija i povezuje se sa ovulskimm oocitom, blastomerama i akrosomnim regijama spermatozoida.[7]
Iza jajovoda, OVGP1 je otkriven u mišjim jajnicima, sjemenicima i epididimisu, što ukazuje na njegovu ulogu izvan oplodnje. Ne otkriva se u mišjoj maternici, grliću materice, vagini, dojkama, sjemenim vezikulama i prostati.[9] OVGP1 je eksprimiran u površinskomm epitelu endometrija u vrijeme implantacije kod miša. Potreban je za održavanje fenotipa receptivnosti i adhezije trofoblasta, a nivoi OVGP1 iRNK smanjeni su u endometriju žena sa rekurentnim neuspjehom implantacije[10]
Reference
uredi- ^ a b c GRCh38: Ensembl release 89: ENSG00000085465 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000074340 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Arias EB, Verhage HG, Jaffe RC (Feb 1995). "Complementary deoxyribonucleic acid cloning and molecular characterization of an estrogen-dependent human oviductal glycoprotein". Biol Reprod. 51 (4): 685–94. doi:10.1095/biolreprod51.4.685. PMID 7819450.
- ^ Lapensee L, Paquette Y, Bleau G (Nov 1997). "Allelic polymorphism and chromosomal localization of the human oviductin gene (MUC9)". Fertil Steril. 68 (4): 702–8. doi:10.1016/S0015-0282(97)00317-8. PMID 9341614.
- ^ a b "Entrez Gene: OVGP1 oviductal glycoprotein 1, 120kDa (mucin 9, oviductin)".
- ^ "UniProt, Q12889" (jezik: eng.). Pristupljeno 3. 12. 2021.CS1 održavanje: nepoznati jezik (link)
- ^ Laheri, Saniya; Modi, Deepak; Bhatt, Purvi (Mar 2017). "Extra-oviductal expression of oviductal glycoprotein 1 in mouse: Detection in testis, epididymis and ovary". Journal of Biosciences. 42 (1): 69–80. doi:10.1007/s12038-016-9657-2. PMID 28229966. S2CID 10274575. Pristupljeno 16. 7. 2018.
- ^ Laheri, Saniya; Ashary, Nancy; Bhatt, Purvi; Modi, Deepak (2018). "Oviductal glycoprotein 1 (OVGP1) is expressed by endometrial epithelium that regulates receptivity and trophoblast adhesion". Journal of Assisted Reproduction and Genetics. 35 (8): 1419–1429. doi:10.1007/s10815-018-1231-4. PMC 6086790. PMID 29968069.
- Laheri, Saniya; Ashary, Nancy; Bhatt, Purvi; Modi, Deepak (2018). "Oviductal glycoprotein 1 (OVGP1) is expressed by endometrial epithelium that regulates receptivity and trophoblast adhesion". Journal of Assisted Reproduction and Genetics. 35 (8): 1419–1429. doi:10.1007/s10815-018-1231-4. PMC 6086790. PMID 29968069.
Dopunska literatura
uredi- Verhage HG, Fazleabas AT, Donnelly K (1988). "The in vitro synthesis and release of proteins by the human oviduct". Endocrinology. 122 (4): 1639–45. doi:10.1210/endo-122-4-1639. PMID 3278893.
- Iontcheva I, Oppenheim FG, Troxler RF (1997). "Human salivary mucin MG1 selectively forms heterotypic complexes with amylase, proline-rich proteins, statherin, and histatins". J. Dent. Res. 76 (3): 734–43. doi:10.1177/00220345970760030501. PMID 9109822. S2CID 39525421.
- Iontcheva I, Oppenheim FG, Offner GD, Troxler RF (2000). "Molecular mapping of statherin- and histatin-binding domains in human salivary mucin MG1 (MUC5B) by the yeast two-hybrid system". J. Dent. Res. 79 (2): 732–9. doi:10.1177/00220345000790020601. PMID 10728974. S2CID 27558675.
- Agarwal A, Yeung WS, Lee KF (2002). "Cloning and characterization of the human oviduct-specific glycoprotein (HuOGP) gene promoter". Mol. Hum. Reprod. 8 (2): 167–75. doi:10.1093/molehr/8.2.167. PMID 11818519.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Lok IH, Briton-Jones CM, Yuen PM, Haines CJ (2003). "Variable expression of oviductin mRNA at different stages of human reproductive cycle". J. Assist. Reprod. Genet. 19 (12): 569–76. doi:10.1023/A:1021263132176. PMC 3455833. PMID 12503889.
- Chen Q, Zhang J, Sweet F (2004). "Homology of primate DNA fragments for estrous-associated oviductal glycoprotein". Hereditas. 139 (1): 75–9. doi:10.1111/j.1601-5223.2003.01640.x. PMID 14641477.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Woo MM, Alkushi A, Verhage HG, et al. (2005). "Gain of OGP, an estrogen-regulated oviduct-specific glycoprotein, is associated with the development of endometrial hyperplasia and endometrial cancer". Clin. Cancer Res. 10 (23): 7958–64. doi:10.1158/1078-0432.CCR-04-1261. PMID 15585630.
- Ling L, Lee YL, Lee KF, et al. (2006). "Expression of human oviductin in an immortalized human oviductal cell line". Fertil. Steril. 84 Suppl 2: 1095–103. doi:10.1016/j.fertnstert.2005.06.006. PMID 16209999.
- Kadam KM, D'Souza SJ, Bandivdekar AH, Natraj U (2006). "Identification and characterization of oviductal glycoprotein-binding protein partner on gametes: epitopic similarity to non-muscle myosin IIA, MYH 9". Mol. Hum. Reprod. 12 (4): 275–82. doi:10.1093/molehr/gal028. PMID 16567366.
- Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.