MIER1

MIER1
Identifikatori
Aliasi	MIER1
Vanjski ID-jevi	OMIM: 616848 MGI: 1918398 HomoloGene: 136176 GeneCards: MIER1
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	66,988,619 bp
Lokacija gena (miš)
Hrom.	Hromosom 4 (miš)
Kraj	103,022,951 bp
Ontologija gena
Molekularna funkcija	• vezivanje sa DNK; • GO:0001948, GO:0016582 vezivanje za proteine; • signal transducer activity; • histone deacetylase activity; • histone deacetylase binding;
Ćelijska komponenta	• citoplazma; • transcription repressor complex; • nukleoplazma; • jedro;
Biološki proces	• positive regulation of I-kappaB kinase/NF-kappaB signaling; • GO:0009373 regulation of transcription, DNA-templated; • transcription, DNA-templated; • GO:0072468 Transdukcija signala; • histone deacetylation;
	Izvori:Amigo / QuickGO
Ortolozi
	57708
	71148
	ENSG00000198160
	ENSMUSG00000028522
	Q8N108
	Q5UAK0
NM_001077700; NM_001077701; NM_001077702; NM_001077703; NM_001077704;
	NM_001146110; NM_001146111; NM_001146112; NM_001146113; NM_001278215; NM_020948; NM_001350530
	NM_001039081; NM_001286221; NM_001286222; NM_001286223; NM_027696
NP_001071168; NP_001071169; NP_001071170; NP_001071171; NP_001071172;
	NP_001139582; NP_001139583; NP_001139584; NP_001139585; NP_001265144; NP_065999; NP_001337459
NP_001034170; NP_001273150; NP_001273151; NP_001273152; NP_081972;
	NP_001391009; NP_001391010; NP_001391011; NP_001391013; NP_001391014
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Protein 1 sa ranom indukcijom mezoderma jest protein koji je kod ljudi kodiran genom MIER1 sa hromosoma 1.^[5]^[6]^[7]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 512 aminokiselina, a molekulska težina 57.983 Da.^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MAEPSVESSS	PGGSATSDDH	EFDPSADMLV	HDFDDERTLE	EEEMMEGETN
FSSEIEDLAR	EGDMPIHELL	SLYGYGSTVR	LPEEDEEEEE	EEEEGEDDED
ADNDDNSGCS	GENKEENIKD	SSGQEDETQS	SNDDPSQSVA	SQDAQEIIRP
RRCKYFDTNS	EVEEESEEDE	DYIPSEDWKK	EIMVGSMFQA	EIPVGICRYK
ENEKVYENDD	QLLWDPEYLP	EDKVIIFLKD	ASRRTGDEKG	VEAIPEGSHI
KDNEQALYEL	VKCNFDTEEA	LRRLRFNVKA	AREELSVWTE	EECRNFEQGL
KAYGKDFHLI	QANKVRTRSV	GECVAFYYMW	KKSERYDFFA	QQTRFGKKKY
NLHPGVTDYM	DRLLDESESA	ASSRAPSPPP	TASNSSNSQS	EKEDGTVSTA
NQNGVSSNGP	GEILNKEEVK	VEGLHINGPT	GGNKKPLHAD	MDTNGYETDN
LTTDPKLAHM	TARNENDFDE	KSERPAKRRR	VNSNGKESPG	SSEFFQEAVS
HGKFEELENT	DD

Interakcije

Pokazalo se da je MIER1 u interakciji sa HDAC1.^[6]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000198160 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028522 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Paterno GD, Ding Z, Lew YY, Nash GW, Mercer FC, Gillespie LL (Jul 2002). "Genomic organization of the human mi-er1 gene and characterization of alternatively spliced isoforms: regulated use of a facultative intron determines subcellular localization". Gene. 295 (1): 79–88. doi:10.1016/S0378-1119(02)00823-5. PMID 12242014.
^ ^a ^b Ding Z, Gillespie LL, Paterno GD (Jan 2003). "Human MI-ER1 alpha and beta function as transcriptional repressors by recruitment of histone deacetylase 1 to their conserved ELM2 domain". Molecular and Cellular Biology. 23 (1): 250–8. doi:10.1128/MCB.23.1.250-258.2003. PMC 140656. PMID 12482978.
^ "Entrez Gene: MIER1 mesoderm induction early response 1 homolog (Xenopus laevis)".
^ "UniProt, Q8N108" (jezik: eng.). Pristupljeno 1. 12. 2021.CS1 održavanje: nepoznati jezik (link)

Dopunska literatura

Paterno GD, Mercer FC, Chayter JJ, Yang X, Robb JD, Gillespie LL (Nov 1998). "Molecular cloning of human er1 cDNA and its differential expression in breast tumours and tumour-derived cell lines". Gene. 222 (1): 77–82. doi:10.1016/S0378-1119(98)00473-9. PMID 9813250.
Nagase T, Kikuno R, Nakayama M, Hirosawa M, Ohara O (Aug 2000). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 7 (4): 273–81. doi:10.1093/dnares/7.4.271. PMID 10997877.
Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H, Sugano S (maj 2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.
Ding Z, Gillespie LL, Mercer FC, Paterno GD (Jul 2004). "The SANT domain of human MI-ER1 interacts with Sp1 to interfere with GC box recognition and repress transcription from its own promoter". The Journal of Biological Chemistry. 279 (27): 28009–16. doi:10.1074/jbc.M403793200. PMID 15117948.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (Apr 2006). "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000198160 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028522 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12242014-5] Paterno GD, Ding Z, Lew YY, Nash GW, Mercer FC, Gillespie LL (Jul 2002). "Genomic organization of the human mi-er1 gene and characterization of alternatively spliced isoforms: regulated use of a facultative intron determines subcellular localization". Gene. 295 (1): 79–88. doi:10.1016/S0378-1119(02)00823-5. PMID 12242014.

[pmid12482978-6] Ding Z, Gillespie LL, Paterno GD (Jan 2003). "Human MI-ER1 alpha and beta function as transcriptional repressors by recruitment of histone deacetylase 1 to their conserved ELM2 domain". Molecular and Cellular Biology. 23 (1): 250–8. doi:10.1128/MCB.23.1.250-258.2003. PMC 140656. PMID 12482978.

[entrez-7] "Entrez Gene: MIER1 mesoderm induction early response 1 homolog (Xenopus laevis)".

[UniProt-8] "UniProt, Q8N108" (jezik: eng.). Pristupljeno 1. 12. 2021.CS1 održavanje: nepoznati jezik (link)

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