E3 ubikvitin-protein ligaza MIB2 jest enzim koji je kod ljudi kodiran genom MIB2 sa hromosoma 1.[5][6]

MIB2
Identifikatori
AliasiMIB2
Vanjski ID-jeviOMIM: 611141 MGI: 2679684 HomoloGene: 16062 GeneCards: MIB2
Lokacija gena (čovjek)
Hromosom 1 (čovjek)
Hrom.Hromosom 1 (čovjek)[1]
Hromosom 1 (čovjek)
Genomska lokacija za MIB2
Genomska lokacija za MIB2
Bend1p36.33Početak1,615,454 bp[1]
Kraj1,630,605 bp[1]
Lokacija gena (miš)
Hromosom 4 (miš)
Hrom.Hromosom 4 (miš)[2]
Hromosom 4 (miš)
Genomska lokacija za MIB2
Genomska lokacija za MIB2
Bend4|4 E2Početak155,739,134 bp[2]
Kraj155,753,655 bp[2]
Ontologija gena
Molekularna funkcija signal transducer activity
vezivanje iona cinka
GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity
vezivanje iona metala
actin binding
GO:0001948, GO:0016582 vezivanje za proteine
GO:0050372 aktivnost sa transferazom ubikvitina
aktivnost sa transferazom
Ćelijska komponenta citoplazma
endozom
early endosome
kompleks ubikvitin-ligaze
citosol
Biološki proces Notch signaling pathway
positive regulation of I-kappaB kinase/NF-kappaB signaling
protein ubiquitination
protein polyubiquitination
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_001170686
NM_001170687
NM_001170688
NM_001170689
NM_080875

NM_001256107
NM_001256108
NM_001256110
NM_145124
NM_001369161

NM_001369162
NM_001369163
NM_001369164
NM_001369165
NM_001369166
NM_001369167
NM_001369168

RefSeq (bjelančevina)

NP_001164157
NP_001164158
NP_001164159
NP_001164160
NP_543151

NP_001243036
NP_001243037
NP_660106
NP_001356090
NP_001356091

NP_001356092
NP_001356093
NP_001356094
NP_001356095
NP_001356096
NP_001356097

Lokacija (UCSC)Chr 1: 1.62 – 1.63 MbChr 4: 155.74 – 155.75 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Aminokiselinska sekvenca

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Dužina polipeptidnog lanca je 1.013 aminokiselina, a molekulska težina 109.939 Da.[7]

1020304050
MGWKPSEARGQSQSFQASGLQPRSLKAARRATGRPDRSRAARPTMDPSAH
RSRAAPPNMDPDPQAGVQVGMRVVRGVDWKWGQQDGGEGGVGTVVELGRH
GSPSTPDRTVVVQWDQGTRTNYRAGYQGAHDLLLYDNAQIGVRHPNIICD
CCKKHGLRGMRWKCRVCLDYDLCTQCYMHNKHELAHAFDRYETAHSRPVT
LSPRQGLPRIPLRGIFQGAKVVRGPDWEWGSQDGGEGKPGRVVDIRGWDV
ETGRSVASVTWADGTTNVYRVGHKGKVDLKCVGEAAGGFYYKDHLPRLGK
PAELQRRVSADSQPFQHGDKVKCLLDTDVLREMQEGHGGWNPRMAEFIGQ
TGTVHRITDRGDVRVQFNHETRWTFHPGALTKHHSFWVGDVVRVIGDLDT
VKRLQAGHGEWTDDMAPALGRVGKVVKVFGDGNLRVAVAGQRWTFSPSCL
VAYRPEEDANLDVAERARENKSSLSVALDKLRAQKSDPEHPGRLVVEVAL
GNAARALDLLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQARAGVD
LPDDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRG
FLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNID
VTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAA
LNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGC
SVNAEDEEGDTALHVALQRHQLLPLVADGAGGDPGPLQLLSRLQASGLPG
SAELTVGAAVACFLALEGADVSYTNHRGRSPLDLAAEGRVLKALQGCAQR
FRERQAGGGAAPGPRQTLGTPNTVTNLHVGAAPGPEAAECLVCSELALLV
LFSPCQHRTVCEECARRMKKCIRCQVVVSKKLRPDGSEVASAAPAPGPPR
QLVEELQSRYRQMEERITCPICIDSHIRLVFQCGHGACAPCGSALSACPI
CRQPIRDRIQIFV

Interakcije

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Pokazalo se da MIB2 (gen) ima interakcije sa aktinom alfa 1.[8]

Reference

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000197530 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029060 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H, Sugano S (maj 2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.
  6. ^ "Entrez Gene: MIB2 mindbomb homolog 2 (Drosophila)".
  7. ^ "UniProt, Q96AX9" (jezik: eng.). Pristupljeno 30. 11. 2021.CS1 održavanje: nepoznati jezik (link)
  8. ^ Takeuchi, Tamotsu; Heng Henry H Q; Ye Christine J; Liang Sheng-Ben; Iwata Jun; Sonobe Hiroshi; Ohtsuki Yuji (Oct 2003). "Down-regulation of a novel actin-binding molecule, skeletrophin, in malignant melanoma". Am. J. Pathol. United States. 163 (4): 1395–404. doi:10.1016/S0002-9440(10)63497-9. ISSN 0002-9440. PMC 1868282. PMID 14507647.

Dopunska literatura

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Vanjski linkovi

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