Vjerovatna mitohondrijska leucl-tRNK sintetaza jest enzim koji je kod ljudi kodiran genom LARS2 sa hromosoma 3.[5]

LARS2
Identifikatori
AliasiLARS2
Vanjski ID-jeviOMIM: 604544 MGI: 2142973 HomoloGene: 6526 GeneCards: LARS2
Lokacija gena (čovjek)
Hromosom 3 (čovjek)
Hrom.Hromosom 3 (čovjek)[1]
Hromosom 3 (čovjek)
Genomska lokacija za LARS2
Genomska lokacija za LARS2
Bend3p21.31Početak45,388,561 bp[1]
Kraj45,554,726 bp[1]
Lokacija gena (miš)
Hromosom 9 (miš)
Hrom.Hromosom 9 (miš)[2]
Hromosom 9 (miš)
Genomska lokacija za LARS2
Genomska lokacija za LARS2
Bend9 F4|9 73.92 cMPočetak123,195,992 bp[2]
Kraj123,291,731 bp[2]
Obrazac RNK ekspresije


Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija aminoacyl-tRNA ligase activity
nucleotide binding
ligase activity
ATP binding
aminoacyl-tRNA editing activity
leucine-tRNA ligase activity
Ćelijska komponenta mitochondrial matrix
mitohondrija
Biološki proces tRNA aminoacylation for protein translation
Biosinteza bjelančevina
leucyl-tRNA aminoacylation
mitochondrial translation
aminoacyl-tRNA metabolism involved in translational fidelity
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_015340
NM_001368263

NM_153168
NM_001348167
NM_001348168

RefSeq (bjelančevina)

NP_056155
NP_001355192

NP_694808
NP_001335096
NP_001335097

Lokacija (UCSC)Chr 3: 45.39 – 45.55 MbChr 9: 123.2 – 123.29 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Aminokiselinska sekvenca

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Dužina polipeptidnog lanca je 903 aminokiseline, а molekulska težina 101.976 Da.[6]

1020304050
MASVWQRLGFYASLLKRQLNGGPDVIKWERRVIPGCTRSIYSATGKWTKE
YTLQTRKDVEKWWHQRIKEQASKISEADKSKPKFYVLSMFPYPSGKLHMG
HVRVYTISDTIARFQKMRGMQVINPMGWDAFGLPAENAAVERNLHPQSWT
QSNIKHMRKQLDRLGLCFSWDREITTCLPDYYKWTQYLFIKLYEAGLAYQ
KEALVNWDPVDQTVLANEQVDEHGCSWRSGAKVEQKYLRQWFIKTTAYAK
AMQDALADLPEWYGIKGMQAHWIGDCVGCHLDFTLKVHGQATGEKLTAYT
ATPEAIYGTSHVAISPSHRLLHGHSSLKEALRMALVPGKDCLTPVMAVNM
LTQQEVPVVILAKADLEGSLDSKIGIPSTSSEDTILAQTLGLAYSEVIET
LPDGTERLSSSAEFTGMTRQDAFLALTQKARGKRVGGDVTSDKLKDWLIS
RQRYWGTPIPIVHCPVCGPTPVPLEDLPVTLPNIASFTGKGGPPLAMASE
WVNCSCPRCKGAAKRETDTMDTFVDSAWYYFRYTDPHNPHSPFNTAVADY
WMPVDLYIGGKEHAVMHLFYARFFSHFCHDQKMVKHREPFHKLLAQGLIK
GQTFRLPSGQYLQREEVDLTGSVPVHAKTKEKLEVTWEKMSKSKHNGVDP
EEVVEQYGIDTIRLYILFAAPPEKDILWDVKTDALPGVLRWQQRLWTLTT
RFIEARASGKSPQPQLLSNKEKAEARKLWEYKNSVISQVTTHFTEDFSLN
SAISQLMGLSNALSQASQSVILHSPEFEDALCALMVMAAPLAPHVTSEIW
AGLALVPRKLCAHYTWDASVLLQAWPAVDPEFLQQPEVVQMAVLINNKAC
GKIPVPQQVARDQDKVHEFVLQSELGVRLLQGRSIKKSFLSPRTALINFL
VQD

Funkcija

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Ovaj gen kodira klasa 1 aminoacil-tRNA sintetaze, mitohondrijjske leucil-tRNK sintetaze. Svaka od dvadeset aminoacil-tRNA sintetaza katalizira aminoacilaciju specifične tRNK ili tRNK izoakceptirajuće porodice sa srodnom amino kiselinom.[7]

Reference

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000011376 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035202 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Sohm B, Sissler M, Park H, King MP, Florentz C (maj 2004). "Recognition of human mitochondrial tRNALeu(UUR) by its cognate leucyl-tRNA synthetase". J Mol Biol. 339 (1): 17–29. doi:10.1016/j.jmb.2004.03.066. PMID 15123417.
  6. ^ "UniProt, Q15031" (jezik: engleski). Pristupljeno 4. 11. 2021.
  7. ^ "Entrez Gene: LARS2 leucyl-tRNA synthetase 2, mitochondrial".

Dopunska literatura

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Vanjski linkovi

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