Tip I inozitol-3,4-bisfosfat 4-fosfataze jest enzim koji je kod ljudi kodiran genom INPP4A sa hromosoma 2.[5][6][7]

INPP4A
Identifikatori
AliasiINPP4A
Vanjski ID-jeviOMIM: 600916 MGI: 1931123 HomoloGene: 2871 GeneCards: INPP4A
Lokacija gena (čovjek)
Hromosom 2 (čovjek)
Hrom.Hromosom 2 (čovjek)[1]
Hromosom 2 (čovjek)
Genomska lokacija za INPP4A
Genomska lokacija za INPP4A
Bend2q11.2Početak98,444,854 bp[1]
Kraj98,594,392 bp[1]
Lokacija gena (miš)
Hromosom 1 (miš)
Hrom.Hromosom 1 (miš)[2]
Hromosom 1 (miš)
Genomska lokacija za INPP4A
Genomska lokacija za INPP4A
Bend1 B|1 15.46 cMPočetak37,338,946 bp[2]
Kraj37,449,817 bp[2]
Obrazac RNK ekspresije




Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity
GO:0001948, GO:0016582 vezivanje za proteine
hydrolase activity
inositol-3,4-bisphosphate 4-phosphatase activity
phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity
inositol-1,3,4-trisphosphate 4-phosphatase activity
Ćelijska komponenta citosol
citoplazma
Biološki proces phosphatidylinositol biosynthetic process
phosphatidylinositol-3-phosphate biosynthetic process
inositol phosphate metabolic process
GO:0072468 Transdukcija signala
GO:0098501, GO:0098502, GO:0006286 Defosforilacija
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)
NM_001134224
NM_001134225
NM_001566
NM_004027
NM_001351424

NM_001351425
NM_001351426
NM_001351427
NM_001351428
NM_001351429

NM_001290797
NM_001290798
NM_001290799
NM_030266
NM_172971

NM_001374629
NM_001374630

RefSeq (bjelančevina)
NP_001127696
NP_001127697
NP_001557
NP_004018
NP_001338353

NP_001338354
NP_001338355
NP_001338356
NP_001338357
NP_001338358

NP_001277726
NP_001277727
NP_001277728
NP_084542
NP_766559

NP_001361558
NP_001361559

Lokacija (UCSC)Chr 2: 98.44 – 98.59 MbChr 1: 37.34 – 37.45 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Aminokiselinska sekvenca

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Dužina polipeptidnog lanca je 977 aminokiselina, a molekulska težina 109.956 Da.[8]

1020304050
MTAREHSPRHGARARAMQRASTIDVAADMLGLSLAGNIQDPDEPILEFSL
ACSELHTPSLDRKPNSFVAVSVTTPPQAFWTKHAQTEIIEGTNNPIFLSS
IAFFQDSLINQMTQVKLSVYDVKDRSQGTMYLLGSGTFIVKDLLQDRHHR
LHLTLRSAESDRVGNITVIGWQMEEKSDQRPPVTRSVDTVNGRMVLPVDE
SLTEALGIRSKYASLRKDTLLKSVFGGAICRMYRFPTTDGNHLRILEQMA
ESVLSLHVPRQFVKLLLEEDAARVCELEELGELSPCWESLRRQIVTQYQT
IILTYQENLTDLHQYRGPSFKASSLKADKKLEFVPTNLHIQRMRVQDDGG
SDQNYDIVTIGAPAAHCQGFKSGGLRKKLHKFEETKKHFEECCTSSGCQS
IIYIPQDVVRAKEIIAQINTLKTQVSYYAERLSRAAKDRSATGLERTLAI
LADKTRQLVTVCDCKLLANSIHGLNAARPDYIASKASPTSTEEEQVMLRN
DQDTLMARWTGRNSRSSLQVDWHEEEWEKVWLNVDKSLECIIQRVDKLLQ
KERLHGEGCEDVFPCAGSCTSKKGNPDSHAYWIRPEDPFCDVPSSPCPST
MPSTACHPHLTTHCSPPPEESSPGEWSEALYPLLTTLTDCVAMMSDKAKK
AMVFLLMQDSAPTIATYLSLQYRRDVVFCQTLTALICGFIIKLRNCLHDD
GFLRQLYTIGLLAQFESLLSTYGEELAMLEDMSLGIMDLRNVTFKVTQAT
SSASADMLPVITGNRDGFNVRVPLPGPLFDALPREIQSGMLLRVQPVLFN
VGINEQQTLAERFGDTSLQEVINVESLVRLNSYFEQFKEVLPEDCLPRSR
SQTCLPELLRFLGQNVHARKNKNVDILWQAAEICRRLNGVRFTSCKSAKD
RTAMSVTLEQCLILQHEHGMAPQVFTQALECMRSEGCRRENTMKNVGSRK
YAFNSLQLKAFPKHYRPPEGTYGKVET

Funkcija

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INPP4A kodira inozitol polifosfat 4-fosfatazu tipa I, jedan od enzima uključenih u fosfatidilinozitolske signalne puteve. Ovaj enzim uklanja fosfatnu grupu na poziciji 4 inozitolskog prstena iz inozitol 3,4-bisfosfata.[7]

Reference

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000040933 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026113 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Norris FA, Auethavekiat V, Majerus PW (Aug 1995). "The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase". J Biol Chem. 270 (27): 16128–33. doi:10.1074/jbc.270.27.16128. PMID 7608176.
  6. ^ Norris FA, Atkins RC, Majerus PW (Oct 1997). "The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family". J Biol Chem. 272 (38): 23859–64. doi:10.1074/jbc.272.38.23859. PMID 9295334.
  7. ^ a b "Entrez Gene: INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa".
  8. ^ "UniProt, Q96PE3" (jezik: engleski). Pristupljeno 17. 11. 2021.

Dopunska literatura

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Vanjski linkovi

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