D-glukuronil C5-epimeraza je enzim koji je kod ljudi kodiran genom GLCE.[5][6]

GLCE
Identifikatori
AliasiGLCE
Vanjski ID-jeviOMIM: 612134 MGI: 2136405 HomoloGene: 14111 GeneCards: GLCE
Lokacija gena (čovjek)
Hromosom 15 (čovjek)
Hrom.Hromosom 15 (čovjek)[1]
Hromosom 15 (čovjek)
Genomska lokacija za GLCE
Genomska lokacija za GLCE
Bend15q23Početak69,160,584 bp[1]
Kraj69,272,217 bp[1]
Lokacija gena (miš)
Hromosom 9 (miš)
Hrom.Hromosom 9 (miš)[2]
Hromosom 9 (miš)
Genomska lokacija za GLCE
Genomska lokacija za GLCE
Bend9|9 BPočetak61,964,530 bp[2]
Kraj62,029,937 bp[2]
Ontologija gena
Molekularna funkcija racemase and epimerase activity, acting on carbohydrates and derivatives
isomerase activity
heparosan-N-sulfate-glucuronate 5-epimerase activity
Ćelijska komponenta integral component of membrane
Golđijeva membrana
Golđijev aparat
membrana
Biološki proces heparan sulfate proteoglycan biosynthetic process
heparin biosynthetic process
glycosaminoglycan biosynthetic process
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_015554
NM_001324091
NM_001324092
NM_001324093
NM_001324094

NM_033320
NM_001368304

RefSeq (bjelančevina)

NP_001311020
NP_001311021
NP_001311022
NP_001311023
NP_056369

NP_201577
NP_001355233

Lokacija (UCSC)Chr 15: 69.16 – 69.27 MbChr 9: 61.96 – 62.03 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Aminokiselinska sekvenca

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Dužina polipeptidnog lanca je 617 aminokiselina, a molekulska težina 70.101 Da.[7]

1020304050
MRCLAARVNYKTLIIICALFTLVTVLLWNKCSSDKAIQFPRRSSSGFRVD
GFEKRAAASESNNYMNHVAKQQSEEAFPQEQQKAPPVVGGFNSNVGSKVL
GLKYEEIDCLINDEHTIKGRREGNEVFLPFTWVEKYFDVYGKVVQYDGYD
RFEFSHSYSKVYAQRAPYHPDGVFMSFEGYNVEVRDRVKCISGVEGVPLS
TQWGPQGYFYPIQIAQYGLSHYSKNLTEKPPHIEVYETAEDRDKNKPNDW
TVPKGCFMANVADKSRFTNVKQFIAPETSEGVSLQLGNTKDFIISFDLKF
LTNGSVSVVLETTEKNQLFTIHYVSNAQLIAFKERDIYYGIGPRTSWSTV
TRDLVTDLRKGVGLSNTKAVKPTKIMPKKVVRLIAKGKGFLDNITISTTA
HMAAFFAASDWLVRNQDEKGGWPIMVTRKLGEGFKSLEPGWYSAMAQGQA
ISTLVRAYLLTKDHIFLNSALRATAPYKFLSEQHGVKAVFMNKHDWYEEY
PTTPSSFVLNGFMYSLIGLYDLKETAGEKLGKEARSLYERGMESLKAMLP
LYDTGSGTIYDLRHFMLGIAPNLARWDYHTTHINQLQLLSTIDESPVFKE
FVKRWKSYLKGSRAKHN
Simboli

Reference

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000138604 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032252 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ghiselli G, Agrawal A (Aug 2005). "The human D-glucuronyl C5-epimerase gene is transcriptionally activated through the β-catenin–TCF4 pathway". Biochem J. 390 (Pt 2): 493–9. doi:10.1042/BJ20050152. PMC 1198929. PMID 15853773.
  6. ^ "Entrez Gene: GLCE glucuronic acid epimerase".
  7. ^ "UniProt, O94923". Pristupljeno 14. 7. 2021.

Dopunska literatura

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