FDFT1
Farnezil-difosfat farneziltransferaza 1 je proteinski enzim koji je kod ljudi kodiran genom FDFT1.[5]
Aminokiselinska sekvenca
urediDužina polipeptidnog lanca je 417 aminokiselina, а molekulska težina 48.115 Da.[6]
10 | 20 | 30 | 40 | 50 | ||||
---|---|---|---|---|---|---|---|---|
MEFVKCLGHP | EEFYNLVRFR | IGGKRKVMPK | MDQDSLSSSL | KTCYKYLNQT | ||||
SRSFAAVIQA | LDGEMRNAVC | IFYLVLRALD | TLEDDMTISV | EKKVPLLHNF | ||||
HSFLYQPDWR | FMESKEKDRQ | VLEDFPTISL | EFRNLAEKYQ | TVIADICRRM | ||||
GIGMAEFLDK | HVTSEQEWDK | YCHYVAGLVG | IGLSRLFSAS | EFEDPLVGED | ||||
TERANSMGLF | LQKTNIIRDY | LEDQQGGREF | WPQEVWSRYV | KKLGDFAKPE | ||||
NIDLAVQCLN | ELITNALHHI | PDVITYLSRL | RNQSVFNFCA | IPQVMAIATL | ||||
AACYNNQQVF | KGAVKIRKGQ | AVTLMMDATN | MPAVKAIIYQ | YMEEIYHRIP | ||||
DSDPSSSKTR | QIISTIRTQN | LPNCQLISRS | HYSPIYLSFV | MLLAALSWQY | ||||
LTTLSQVTED | YVQTGEH |
Funkcija
urediOvaj gen kodira membranski povezani enzim koji se nalazi na tački grananja mevalonatnog puta. Kodirani protein je prvi specifični enzim u biosintezi holesterola, koji katalizira dimerizaciju dvije molekule farnezil difosfata u reakciji u dva koraka u obliku skvalena.
Reference
uredi- ^ a b c ENSG00000284967 GRCh38: Ensembl release 89: ENSG00000079459, ENSG00000284967 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021273 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Farnesyl-diphosphate farnesyltransferase 1". Pristupljeno 25. 6. 2016.
- ^ "UniProt, P37268" (jezik: engleski). Pristupljeno 17. 9. 2021.
Dopunska literatura
uredi- Kavanagh KL, Guo K, Dunford JE, Wu X, Knapp S, Ebetino FH, Rogers MJ, Russell RG, Oppermann U (2006). "The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs". Proc. Natl. Acad. Sci. U.S.A. 103 (20): 7829–34. Bibcode:2006PNAS..103.7829K. doi:10.1073/pnas.0601643103. PMC 1472530. PMID 16684881.