CpG-vezujući protein (CGBP), znan i kao CXXC-tip proteina 1 cinkovog prsta (CXXC1) ili PHD prst CXXC domen-sadržavajućeg proteina 1 (PCCX1) je protein koji je kod ljudi kodiran genom CXXC1.[5][6][7]

CXXC1
Dostupne strukture
PDBPretraga ortologa: PDBe RCSB
Spisak PDB ID kodova

3QMB, 3QMC, 3QMD, 3QMG, 3QMH, 3QMI

Identifikatori
AliasiCXXC1
Vanjski ID-jeviOMIM: 609150 MGI: 1921572 HomoloGene: 32221 GeneCards: CXXC1
Lokacija gena (čovjek)
Hromosom 18 (čovjek)
Hrom.Hromosom 18 (čovjek)[1]
Hromosom 18 (čovjek)
Genomska lokacija za CXXC1
Genomska lokacija za CXXC1
Bend18q21.1Početak50,282,343 bp[1]
Kraj50,287,839 bp[1]
Lokacija gena (miš)
Hromosom 18 (miš)
Hrom.Hromosom 18 (miš)[2]
Hromosom 18 (miš)
Genomska lokacija za CXXC1
Genomska lokacija za CXXC1
Bend18|18 E2Početak74,349,195 bp[2]
Kraj74,354,567 bp[2]
Obrazac RNK ekspresije


Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija vezivanje sa DNK
vezivanje iona cinka
GO:0001948, GO:0016582 vezivanje za proteine
GO:0001158 cis-regulatory region sequence-specific DNA binding
histone methyltransferase activity (H3-K4 specific)
vezivanje iona metala
unmethylated CpG binding
GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific
Ćelijska komponenta nuclear matrix
nuclear speck
jedro
nukleoplazma
histone methyltransferase complex
citosol
Set1C/COMPASS complex
Biološki proces GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated
IRE1-mediated unfolded protein response
histone H3-K4 methylation
GO:0009373 regulation of transcription, DNA-templated
transcription, DNA-templated
GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_001101654
NM_014593

NM_028868
NM_001378844

RefSeq (bjelančevina)

NP_001095124
NP_055408

NP_083144
NP_001365773

Lokacija (UCSC)Chr 18: 50.28 – 50.29 MbChr 18: 74.35 – 74.35 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Dužina polipeptidnog lanca je 656 aminokiselina, а molekulska težina — 75.712.[8].

Proteini koji sadrže motiv CXXC u svom domenu koji veže DNK, kao što je CXXC1, prepoznaju sekvence CpG i reguliraju ekspresiju gena.[6]

Aminokiselinska sekvenca

Simboli
1020304050
MEGDGSDPEPPDAGEDSKSENGENAPIYCICRKPDINCFMIGCDNCNEWF
HGDCIRITEKMAKAIREWYCRECREKDPKLEIRYRHKKSRERDGNERDSS
EPRDEGGGRKRPVPDPDLQRRAGSGTGVGAMLARGSASPHKSSPQPLVAT
PSQHHQQQQQQIKRSARMCGECEACRRTEDCGHCDFCRDMKKFGGPNKIR
QKCRLRQCQLRARESYKYFPSSLSPVTPSESLPRPRRPLPTQQQPQPSQK
LGRIREDEGAVASSTVKEPPEATATPEPLSDEDLPLDPDLYQDFCAGAFD
DHGLPWMSDTEESPFLDPALRKRAVKVKHVKRREKKSEKKKEERYKRHRQ
KQKHKDKWKHPERADAKDPASLPQCLGPGCVRPAQPSSKYCSDDCGMKLA
ANRIYEILPQRIQQWQQSPCIAEEHGKKLLERIRREQQSARTRLQEMERR
FHELEAIILRAKQQAVREDEESNEGDSDDTDLQIFCVSCGHPINPRVALR
HMERCYAKYESQTSFGSMYPTRIEGATRLFCDVYNPQSKTYCKRLQVLCP
EHSRDPKVPADEVCGCPLVRDVFELTGDFCRLPKRQCNRHYCWEKLRRAE
VDLERVRVWYKLDELFEQERNVRTAMTNRAGLLALMLHQTIQHDPLTTDL
RSSADR

Reference

uredi
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000154832 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024560 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Fujino T, Hasegawa M, Shibata S, Kishimoto T, Imai S, Takano T (Jun 2000). "PCCX1, a novel DNA-binding protein with PHD finger and CXXC domain, is regulated by proteolysis". Biochem Biophys Res Commun. 271 (2): 305–310. doi:10.1006/bbrc.2000.2614. PMID 10799292.
  6. ^ a b Voo KS, Carlone DL, Jacobsen BM, Flodin A, Skalnik DG (Mar 2000). "Cloning of a mammalian transcriptional activator that binds unmethylated CpG motifs and shares a CXXC domain with DNA methyltransferase, human trithorax, and methyl-CpG binding domain protein 1". Mol Cell Biol. 20 (6): 2108–2121. doi:10.1128/MCB.20.6.2108-2121.2000. PMC 110827. PMID 10688657.
  7. ^ "Entrez Gene: CXXC1 CXXC finger 1 (PHD domain)".
  8. ^ "UniProt, Q9P0U4". Pristupljeno 12. 9. 2017.

Vanjski linkovi

uredi

Dopunska literatura

uredi