Protein 80 sa upredenom zavojnicom jest protein koji je kod ljudi kodiran genom CCDC80 sa hromosoma 3.[5][6][7]

CCDC80
Identifikatori
AliasiCCDC80
Vanjski ID-jeviOMIM: 608298 MGI: 1915146 HomoloGene: 12206 GeneCards: CCDC80
Lokacija gena (čovjek)
Hromosom 3 (čovjek)
Hrom.Hromosom 3 (čovjek)[1]
Hromosom 3 (čovjek)
Genomska lokacija za CCDC80
Genomska lokacija za CCDC80
Bend3q13.2Početak112,596,797 bp[1]
Kraj112,649,530 bp[1]
Lokacija gena (miš)
Hromosom 16 (miš)
Hrom.Hromosom 16 (miš)[2]
Hromosom 16 (miš)
Genomska lokacija za CCDC80
Genomska lokacija za CCDC80
Bend16|16 B5Početak44,913,765 bp[2]
Kraj44,948,440 bp[2]
Obrazac RNK ekspresije


Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija fibronectin binding
glycosaminoglycan binding
heparin binding
Ćelijska komponenta extracellular region
basement membrane
interstitial matrix
GO:0005578 Vanćelijski matriks
Biološki proces extracellular matrix organization
positive regulation of cell-substrate adhesion
response to bacterium
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_199512
NM_199511
NM_178274

NM_026439

RefSeq (bjelančevina)

NP_955805
NP_955806

NP_080715

Lokacija (UCSC)Chr 3: 112.6 – 112.65 MbChr 16: 44.91 – 44.95 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Aminokiselinska sekvenca

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Dužina polipeptidnog lanca je 950 aminokiselina, а molekulska težina 108.174 Da.[8]

1020304050
MTWRMGPRFTMLLAMWLVCGSEPHPHATIRGSHGGRKVPLVSPDSSRPAR
FLRHTGRSRGIERSTLEEPNLQPLQRRRSVPVLRLARPTEPPARSDINGA
AVRPEQRPAARGSPREMIRDEGSSARSRMLRFPSGSSSPNILASFAGKNR
VWVISAPHASEGYYRLMMSLLKDDVYCELAERHIQQIVLFHQAGEEGGKV
RRITSEGQILEQPLDPSLIPKLMSFLKLEKGKFGMVLLKKTLQVEERYPY
PVRLEAMYEVIDQGPIRRIEKIRQKGFVQKCKASGVEGQVVAEGNDGGGG
AGRPSLGSEKKKEDPRRAQVPPTRESRVKVLRKLAATAPALPQPPSTPRA
TTLPPAPATTVTRSTSRAVTVAARPMTTTAFPTTQRPWTPSPSHRPPTTT
EVITARRPSVSENLYPPSRKDQHRERPQTTRRPSKATSLESFTNAPPTTI
SEPSTRAAGPGRFRDNRMDRREHGHRDPNVVPGPPKPAKEKPPKKKAQDK
ILSNEYEEKYDLSRPTASQLEDELQVGNVPLKKAKESKKHEKLEKPEKEK
KKKMKNENADKLLKSEKQMKKSEKKSKQEKEKSKKKKGGKTEQDGYQKPT
NKHFTQSPKKSVADLLGSFEGKRRLLLITAPKAENNMYVQQRDEYLESFC
KMATRKISVITIFGPVNNSTMKIDHFQLDNEKPMRVVDDEDLVDQRLISE
LRKEYGMTYNDFFMVLTDVDLRVKQYYEVPITMKSVFDLIDTFQSRIKDM
EKQKKEGIVCKEDKKQSLENFLSRFRWRRRLLVISAPNDEDWAYSQQLSA
LSGQACNFGLRHITILKLLGVGEEVGGVLELFPINGSSVVEREDVPAHLV
KDIRNYFQVSPEYFSMLLVGKDGNVKSWYPSPMWSMVIVYDLIDSMQLRR
QEMAIQQSLGMRCPEDEYAGYGYHSYHQGYQDGYQDDYRHHESYHHGYPY

Funkcija

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Bioinformatička analiza sugerira da je protein CCDC80 peroksiredoksin.[9]

Reference

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000091986 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022665 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Bonaldo MF, Lennon G, Soares MB (maj 1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  6. ^ Liu Y, Monticone M, Tonachini L, Mastrogiacomo M, Marigo V, Cancedda R, Castagnola P (Aug 2004). "URB expression in human bone marrow stromal cells and during mouse development". Biochem Biophys Res Commun. 322 (2): 497–507. doi:10.1016/j.bbrc.2004.07.161. PMID 15325258.
  7. ^ "Entrez Gene: CCDC80 coiled-coil domain containing 80".
  8. ^ "UniProt, Q76M96" (jezik: engleski). Pristupljeno 6. 11. 2021.
  9. ^ Pawłowski K, Muszewska A, Lenart A, et al. (2010). "A widespread peroxiredoxin-like domain present in tumor suppression- and progression-implicated proteins". BMC Genomics. 11: 590. doi:10.1186/1471-2164-11-590. PMC 3091736. PMID 20964819.

Dopunska literatura

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Vanjski linkovi

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