5-azacitidin-inducirani protein 2 jest protein koji je kod ljudi kodiran genom AZI2 sa hromosoma 3.[5][6]

AZI2
Identifikatori
AliasiAZI2
Vanjski ID-jeviOMIM: 609916 MGI: 1351332 HomoloGene: 8443 GeneCards: AZI2
Lokacija gena (čovjek)
Hromosom 3 (čovjek)
Hrom.Hromosom 3 (čovjek)[1]
Hromosom 3 (čovjek)
Genomska lokacija za AZI2
Genomska lokacija za AZI2
Bend3p24.1Početak28,315,003 bp[1]
Kraj28,349,050 bp[1]
Lokacija gena (miš)
Hromosom 9 (miš)
Hrom.Hromosom 9 (miš)[2]
Hromosom 9 (miš)
Genomska lokacija za AZI2
Genomska lokacija za AZI2
Bend9|9 F3Početak118,040,499 bp[2]
Kraj118,069,794 bp[2]
Obrazac RNK ekspresije
Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija GO:0001948, GO:0016582 vezivanje za proteine
Ćelijska komponenta citoplazma
Biološki proces interleukin-6 production
dendritic cell differentiation
GO:0032617 cytokine production
tumor necrosis factor production
interferon-alpha production
I-kappaB kinase/NF-kappaB signaling
T cell activation
dendritic cell proliferation
GO:0007067 Mitoza
GO:0022415 viral process
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_001134432
NM_001134433
NM_001271650
NM_022461
NM_203326

NM_001048146
NM_001286507
NM_001286508
NM_013727

RefSeq (bjelančevina)

NP_001127904
NP_001127905
NP_001258579
NP_071906

NP_001041611
NP_001273436
NP_001273437
NP_038755

Lokacija (UCSC)Chr 3: 28.32 – 28.35 MbChr 9: 118.04 – 118.07 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Aminokiselinska sekvenca

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Dužina polipeptidnog lanca je 392 aminokiseline, а molekulska težina 44.935 Da.[7]

1020304050
MDALVEDDICILNHEKAHKRDTVTPVSIYSGDESVASHFALVTAYEDIKK
RLKDSEKENSLLKKRIRFLEEKLIARFEEETSSVGREQVNKAYHAYREVC
IDRDNLKSKLDKMNKDNSESLKVLNEQLQSKEVELLQLRTEVETQQVMRN
LNPPSSNWEVEKLSCDLKIHGLEQELELMRKECSDLKIELQKAKQTDPYQ
EDNLKSRDLQKLSISSDNMQHAYWELKREMSNLHLVTQVQAELLRKLKTS
TAIKKACAPVGCSEDLGRDSTKLHLMNFTATYTRHPPLLPNGKALCHTTS
SPLPGDVKVLSEKAILQSWTDNERSIPNDGTCFQEHSSYGRNSLEDNSWV
FPSPPKSSETAFGETKTKTLPLPNLPPLHYLDQHNQNCLYKN

Funkcija

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AZI2, ili NAP1, doprinosi aktivaciji NFKB (vidi MIM 164011) zavisne ekspresije gena, aktiviranjem IKK-vezanih kinaza, kao što je NAK (TBK1; MIM 604834) (Fujita et al., 2003; prema OMIM-u)[6]

Reference

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163512 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039285 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Miyagawa J, Muguruma M, Aoto H, Suetake I, Nakamura M, Tajima S (Jan 2000). "Isolation of the novel cDNA of a gene of which expression is induced by a demethylating stimulus". Gene. 240 (2): 289–95. doi:10.1016/S0378-1119(99)00450-3. PMID 10580148.
  6. ^ a b "Entrez Gene: AZI2 5-azacytidine induced 2".
  7. ^ "UniProt, Q9H6S1" (jezik: engleski). Pristupljeno 1. 11. 2021.

Dopunska literatura

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Vanjski linkovi

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