AE-vezujući protein 1 je protein koji je kod ljudi kodiran genom AEBP1.[5]

AEBP1
Identifikatori
AliasiAEBP1
Vanjski ID-jeviOMIM: 602981 MGI: 1197012 HomoloGene: 878 GeneCards: AEBP1
Lokacija gena (čovjek)
Hromosom 7 (čovjek)
Hrom.Hromosom 7 (čovjek)[1]
Hromosom 7 (čovjek)
Genomska lokacija za AEBP1
Genomska lokacija za AEBP1
Bend7p13Početak44,104,345 bp[1]
Kraj44,114,562 bp[1]
Lokacija gena (miš)
Hromosom 11 (miš)
Hrom.Hromosom 11 (miš)[2]
Hromosom 11 (miš)
Genomska lokacija za AEBP1
Genomska lokacija za AEBP1
Bend11|11 A1Početak5,811,947 bp[2]
Kraj5,822,088 bp[2]
Ontologija gena
Molekularna funkcija vezivanje sa DNK
RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0001106 transcription corepressor activity
GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity
vezivanje iona cinka
calmodulin binding
GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific
metallocarboxypeptidase activity
carboxypeptidase activity
serine-type carboxypeptidase activity
extracellular matrix structural constituent
collagen binding
Ćelijska komponenta citoplazma
GO:0005578 Vanćelijski matriks
Egzosom
jedro
Vanćelijsko
extracellular region
collagen-containing extracellular matrix
Biološki proces skeletal system development
GO:0009373 regulation of transcription, DNA-templated
peptide metabolic process
protein processing
muscle organ development
GO:1901227 negative regulation of transcription by RNA polymerase II
transcription, DNA-templated
Proteoliza
regulation of collagen fibril organization
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_001129

NM_001291857
NM_009636

RefSeq (bjelančevina)

NP_001120

NP_001278786
NP_033766

Lokacija (UCSC)Chr 7: 44.1 – 44.11 MbChr 11: 5.81 – 5.82 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Aminokiselinska sekvenca

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Dužina polipeptidnog lanca je 1.158 aminokiselina, а molekulska težina 130.929 Da.[6]

1020304050
MAAVRGAPLLSCLLALLALCPGGRPQTVLTDDEIEEFLEGFLSELEPEPR
EDDVEAPPPPEPTPRVRKAQAGGKPGKRPGTAAEVPPEKTKDKGKKGKKD
KGPKVPKESLEGSPRPPKKGKEKPPKATKKPKEKPPKATKKPKEKPPKAT
KKPKEKPPKATKKPPSGKRPPILAPSETLEWPLPPPPSPGPEELPQEGGA
PLSNNWQNPGEETHVEAREHQPEPEEETEQPTLDYNDQIEREDYEDFEYI
RRQKQPRPPPSRRRRPERVWPEPPEEKAPAPAPEERIEPPVKPLLPPLPP
DYGDGYVIPNYDDMDYYFGPPPPQKPDAERQTDEEKEELKKPKKEDSSPK
EETDKWAVEKGKDHKEPRKGEELEEEWTPTEKVKCPPIGMESHRIEDNQI
RASSMLRHGLGAQRGRLNMQTGATEDDYYDGAWCAEDDARTQWIEVDTRR
TTRFTGVITQGRDSSIHDDFVTTFFVGFSNDSQTWVMYTNGYEEMTFHGN
VDKDTPVLSELPEPVVARFIRIYPLTWNGSLCMRLEVLGCSVAPVYSYYA
QNEVVATDDLDFRHHSYKDMRQLMKVVNEECPTITRTYSLGKSSRGLKIY
AMEISDNPGEHELGEPEFRYTAGIHGNEVLGRELLLLLMQYLCREYRDGN
PRVRSLVQDTRIHLVPSLNPDGYEVAAQMGSEFGNWALGLWTEEGFDIFE
DFPDLNSVLWGAEERKWVPYRVPNNNLPIPERYLSPDATVSTEVRAIIAW
MEKNPFVLGANLNGGERLVSYPYDMARTPTQEQLLAAAMAAARGEDEDEV
SEAQETPDHAIFRWLAISFASAHLTLTEPYRGGCQAQDYTGGMGIVNGAK
WNPRTGTINDFSYLHTNCLELSFYLGCDKFPHESELPREWENNKEALLTF
MEQVHRGIKGVVTDEQGIPIANATISVSGINHGVKTASGGDYWRILNPGE
YRVTAHAEGYTPSAKTCNVDYDIGATQCNFILARSNWKRIREIMAMNGNR
PIPHIDPSRPMTPQQRRLQQRRLQHRLRLRAQMRLRRLNATTTLGPHTVP
PTLPPAPATTLSTTIEPWGLIPPTTAGWEESETETYTEVVTEFGTEVEPE
FGTKVEPEFETQLEPEFETQLEPEFEEEEEEEKEEEIATGQAFPFTTVET
YTVNFGDF

Funkcija

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AE-vezujući protein 1 je član proteinske porodice karboksipeptidaza A. Protein može funkcionirati kao transkripcijski represor i imati ulogu u adipogenezi i diferencijaciji ćelija u glatkim mišićima. Studije na miševima sugeriraju da gen AEBP1 koji kodira proteinske funkcije u zacjeljivanju rana i razvoju trbušnog zida. Prekomjerna ekspresija ovog gena povezana je s glioblastomomom.[5]

Reference

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000106624 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020473 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: AE binding protein 1".
  6. ^ "UniProt, Q8IUX7" (jezik: engleski). Pristupljeno 22. 9. 2021.

Dopunska literatura

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Vanjski linkovi

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