Encoding.com's API can encrypt to a variety of native encryption as well as several commercial DRM platforms. For FlashAccess, PlayReady, Widevine, Atlas, or BuyDRM KeyOS CPIX, please see their respective sections in the API documents.
These more generic open-source methods below are supported by all formats except iphone_stream, ipad_stream, advanced_mss, and advanced_dash formats. Those formats have their own encryption implementation, please refer to their documentation on how to use them.
A destination is required when using encryption without specifying a encryption_key or encryption_key_file. The key used for encryption will be uploaded to the same destination as output file, with a .key extension.