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  1. The Zéro allergie research clinic (Saguenay, Canada) is a clinical and research initiative in oral immunotherapy (OIT) for managing IgE-mediated food allergy (FA). A total of 183 children with FA and 27 non-aller...

    Authors: Bénédicte L. Tremblay, Philippe Bégin, Frédérique Gagnon-Brassard, Anne-Marie Boucher-Lafleur, Marie-Ève Lavoie, Anne-Marie Madore, Sarah Lavoie, Cloé Rochefort-Beaudoin, Claudia Nuncio-Naud, Charles Morin, Guy Parizeault and Catherine Laprise
    Citation: Allergy, Asthma & Clinical Immunology 2024 20:59
    Content type: Research Published on:

  2. Rasburicase, a recombinant urate oxidase enzyme, has potent efficacy in controlling uric acid and is widely used to prevent tumor lysis syndrome in high-risk patients owing to its low toxicity profile. However...

    Authors: Yoshikazu Utsu, Natsuho Kaneda, Makio Kawakami, Shin-ichi Masuda, Hironori Arai, Sonoko Shimoji, Rena Matsumoto, Takafumi Tsushima, Kazusuke Tanaka, Kosuke Matsuo, Chiharu Kimeda, Shiho Konno and Nobuyuki Aotsuka
    Citation: Allergy, Asthma & Clinical Immunology 2024 20:58
    Content type: Case Report Published on:

  3. Peanut allergy is a common food allergy with potentially life-threatening implications. Early oral immunotherapy for peanut allergy (P-EOIT) has been shown to be effective and safe in research and specialty cl...

    Authors: Victoria Landry, Rachel Lewis, William Lewis, Lyndsey MacDonald, Beth Carson, Kavish Chandra, Jacqueline Fraser, Andrew J. Flewelling, Paul Atkinson and Chris Vaillancourt
    Citation: Allergy, Asthma & Clinical Immunology 2024 20:57
    Content type: Research Published on:

  4. Patients with asthma with an eosinophilic phenotype may be eligible for additional treatment options to improve disease control; however, the prevalence and frequency of eosinophil testing is unknown. This stu...

    Authors: Sameer Mathur, Thomas Corbridge, Elizabeth Packnett, Krutika Jariwala-Parikh and Arijita Deb
    Citation: Allergy, Asthma & Clinical Immunology 2024 20:56
    Content type: Research Published on:

  5. Penicillin allergy adversely impacts patient care, yet most cases do not have true allergies. Clinicians require efficient, reliable clinical tools to identify low risk patients who can be safely de-labeled. O...

    Authors: Joanne Wang, Chelsea Elwood, Vanessa Paquette, Natasha Kwan, Stephanie Erdle, Melissa Watt, Julie Van Schalkwyk, Jeffrey N. Bone, Ashley Roberts, Raymond Mak and Tiffany Wong
    Citation: Allergy, Asthma & Clinical Immunology 2024 20:55
    Content type: Research Published on:

  6. Oral immunotherapy (OIT) is an increasingly utilized management strategy for IgE-mediated food allergy. Despite promising efficacy and effectiveness, there is still a lack of data surrounding the reasons for d...

    Authors: Amy A. Plessis, Scott B. Cameron, Rosemary Invik, Mariam Hanna, Douglas P. Mack and Victoria E. Cook
    Citation: Allergy, Asthma & Clinical Immunology 2024 20:54
    Content type: Research Published on:

  7. Oral immunotherapy (OIT) has become the standard of care for children with food allergy (FA) and has substantially improved their quality of life. The effect of OIT on the quality of life in adults, however, h...

    Authors: Na’ama Epstein-Rigbi, Michael B. Levy, Liat Nachshon, Yael Koren, Michael R. Goldberg and Arnon Elizur
    Citation: Allergy, Asthma & Clinical Immunology 2024 20:53
    Content type: Research Published on:

  8. Primary immunodeficiency diseases (PIDs), also referred to as inborn errors of immunity, constitute a group of genetic conditions that affect the immune system. The current standard of care for patients with P...

    Authors: Dorothea Grosse-Kreul, Crystal Allen, Chrystyna Kalicinsky and Paul K. Keith
    Citation: Allergy, Asthma & Clinical Immunology 2024 20:52
    Content type: Review Published on:

  9. The aim of this study was to investigate the influence of osthole (OS) on asthma-induced airway epithelial cell apoptosis and inflammation by restraining Th2 differentiation through suppressing TSLP/NF-κB.

    Authors: Yanli Li, Yushan Zhou, Liqiong Liu, Yunfeng Yang, Yanhong Liu, Dailing Yan, Juyan Chen and Yi Xiao
    Citation: Allergy, Asthma & Clinical Immunology 2024 20:51
    Content type: Research Published on:

  10. Hereditary angioedema with normal C1-inhibitor function (HAE nC1-INH) and idiopathic angioedema of unknown etiology (AE-UNK) are rare conditions that cause recurrent subcutaneous and submucosal swelling. The c...

    Authors: Adil Adatia, Jean-Nicolas Boursiquot, Dawn Goodyear, Chrystyna Kalicinsky, Amin Kanani, Susan Waserman, Michelle M. L. Nguyen, Abhinav Wadhwa, Jessica Weiss, Ahmed El-Zoeiby and Stephen Betschel
    Citation: Allergy, Asthma & Clinical Immunology 2024 20:50
    Content type: Research Published on:

  11. Abrocitinib, an oral small-molecule Janus kinase 1 (JAK1) inhibitor, has been widely accepted for the treatment of moderate-to-severe atopic dermatitis (AD). Currently there is a paucity of data on the adverse...

    Authors: Shirui Chen, Chongtu Yang and Yonghong Lu
    Citation: Allergy, Asthma & Clinical Immunology 2024 20:49
    Content type: Case Report Published on:

  13. The safety, tolerability, and immunogenicity of hyaluronidase-facilitated subcutaneous immunoglobulin (fSCIG) 10% (dual-vial unit of human immunoglobulin 10% and recombinant human hyaluronidase [rHuPH20]) were...

    Authors: Peter Čižnár, Marion Roderick, Helen Schneiderova, Miloš Jeseňák, Gergely Kriván, Nicholas Brodszki, Stephen Jolles, Charles Atisso, Katharina Fielhauer, Shumyla Saeed-Khawaja, Barbara McCoy and Leman Yel
    Citation: Allergy, Asthma & Clinical Immunology 2024 20:47
    Content type: Research Published on:

  14. PF-06817024 is a humanized antibody against interleukin-33 that has the potential to inhibit type 2 inflammation. An exploratory analysis of the pharmacodynamics and clinical effects of single and repeat doses...

    Authors: Spencer I. Danto, Nikolaos Tsamandouras, Padma Reddy, Steven A. Gilbert, Jessica Y. Mancuso, Karen Page, Jean S. Beebe, Elena Peeva and Michael S. Vincent
    Citation: Allergy, Asthma & Clinical Immunology 2024 20:46
    Content type: Short report Published on:

  15. Allergic rhinitis (AR) is a prevalent disease in Canada that affects both children and adults. Several guidelines for the management of AR have been published by professional allergy societies worldwide. Howev...

    Authors: Anne K. Ellis, Victoria Cook, Paul K. Keith, Sean R. Mace, William Moote, Andrew O’Keefe, Jaclyn Quirt, Lana Rosenfield, Peter Small and Wade Watson
    Citation: Allergy, Asthma & Clinical Immunology 2024 20:45
    Content type: Position article and guidelines Published on:

  17. Hereditary angioedema (HAE) is characterized by debilitating attacks of tissue swelling in various locations. While guidelines recommend the importance of early on-demand treatment, recent data indicate that m...

    Authors: Stephen D. Betschel, Teresa Caballero, Douglas H. Jones, Hilary J. Longhurst, Michael Manning, Sally van Kooten, Markus Heckmann, Sherry Danese, Ledia Goga and Autumn Ford Burnette
    Citation: Allergy, Asthma & Clinical Immunology 2024 20:43
    Content type: Research Published on:

  18. Glucocorticoids are widely used in inhalation aerosol therapy for wheezing diseases. This study aims to explore guardians’ knowledge and attitude towards inhaled corticosteroids (ICS) aerosol therapy and the m...

    Authors: Zuojiao Liu, Haiqing Dai, Fengjiao Tao, Xiaoxiao He and Ting Jin
    Citation: Allergy, Asthma & Clinical Immunology 2024 20:42
    Content type: Research Published on:

  19. Associations between psoriasis and allergic diseases (asthma, rhinitis, and eczema) in children have been reported in a limited number of studies, and the association between psoriasis and multimorbidity (co-o...

    Authors: Ali H. Ziyab, Yaser Ali, Dina Zein, Manal Al-Kandari, John W. Holloway and Wilfried Karmaus
    Citation: Allergy, Asthma & Clinical Immunology 2024 20:41
    Content type: Research Published on:

  20. To explore the role of different cells and molecules in the pathogenesis of allergic rhinitis (AR) with positive Artemisia allergen by detecting their expression levels.

    Authors: Li-Ping Guo, Min Yan, Rui-Bing Niu, Lei Liu, Jing-Ru Yang, Rui-Lian Chen, Bao-Sheng Duan, Cui-Cui Li and Jian-Xiong Li
    Citation: Allergy, Asthma & Clinical Immunology 2024 20:40
    Content type: Research Published on:

  21. Azathioprine is a purine synthesis inhibitor used as an immunosuppressive therapy for many immune-mediated diseases. Azathioprine hypersensitivity reaction is a rare, life-threatening adverse reaction characte...

    Authors: Samuel Su, Yu Ming Wang, Karver Zaborniak, Sate Hamza, Davinder S. Jassal and Marcus Blouw
    Citation: Allergy, Asthma & Clinical Immunology 2024 20:39
    Content type: Case Report Published on:

  23. Despite asthma guidelines’ recommended emergency department preventative strategies (EDPS), repeat asthma-related emergency department (ED) visits remain frequent.

    Authors: Tahereh Haji, Lynnette Lyzwinski, Cara Dhaliwal, Garvin Leung, Sandra Giangioppo and Dhenuka Radhakrishnan
    Citation: Allergy, Asthma & Clinical Immunology 2024 20:37
    Content type: Research Published on:

  24. Recombinant human Interleukin receptor antagonist (rhIL-Ra) can bind to the IL-1 receptor on the cell membrane and reversibly blocks the proinflammatory signaling pathway. However, its effect on allergic rhini...

    Authors: Haibing Li, Chanjuan Di, Yanbing Xie, Yuexia Bai and Yongxue Liu
    Citation: Allergy, Asthma & Clinical Immunology 2024 20:36
    Content type: Research Published on:

  25. Anaphylaxis is the most severe form of acute systemic and potentially life-threatening reactions triggered by mast and basophilic cells. Recent studies show a worldwide incidence between 50 and 112 occurrences...

    Authors: Simone Ehrhard, Vicky Eyb, Dominic Gautschi, Stefan K. Schauber, Meret E. Ricklin, Jolanta Klukowska-Rötzler, Aristomenis K. Exadaktylos and Arthur Helbling
    Citation: Allergy, Asthma & Clinical Immunology 2024 20:35
    Content type: Research Published on:

  26. Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous disease characterized by inflammation of the nasal and sinus mucosa. The inflammatory patterns may differ among patients, leading to differe...

    Authors: Yu-Tsai Lin, Ming-Hsien Tsai, Yan-Ye Su and Shun-Chen Huang
    Citation: Allergy, Asthma & Clinical Immunology 2024 20:34
    Content type: Research Published on:

  27. Diet restrictions and fear of adverse reactions put a significant burden on the nutrition, growth and life style of children and adults with food allergies. While various disease-modifying options are pursued,...

    Authors: Lydia M. Theodoropoulou and Niamh A. Cullen
    Citation: Allergy, Asthma & Clinical Immunology 2024 20:33
    Content type: Research Published on:

  29. Since the last guidance was published by the Canadian Thoracic Society, there have been several advances in the clinical management of severe asthma. To gain a better understanding of the current standards of ...

    Authors: Krystelle Godbout, Harold Kim, Irvin Mayers, James Paterson and Charles K. N. Chan
    Citation: Allergy, Asthma & Clinical Immunology 2024 20:31
    Content type: Research Published on:

  30. Immunoglobulin replacement therapy is a standard treatment for patients with antibody production deficiencies, which is of interest in patients with chronic obstructive pulmonary disease (COPD). This systemati...

    Authors: Justin J. Y. Kim, Liz Dennett, Maria B. Ospina, Anne Hicks, Harissios Vliagoftis and Adil Adatia
    Citation: Allergy, Asthma & Clinical Immunology 2024 20:30
    Content type: Research Published on:

  31. Serum-sickness like reactions (SSLRs) to amoxicillin have been documented in the medical literature. Beta-lactams are important and commonly used medications especially in the pediatric population. Often, SSLR...

    Authors: Devyani Bakshi, Xinxin Tang and Susan Waserman
    Citation: Allergy, Asthma & Clinical Immunology 2024 20:29
    Content type: Case report Published on:

  32. Hereditary angioedema (HAE) poses diagnostic challenges due to its episodic, non-specific symptoms and overlapping conditions. This study focuses on the genetic basis of HAE, particularly focusing on unresolve...

    Authors: Marija Rozevska, Adine Kanepa, Signe Purina, Linda Gailite, Inga Nartisa, Henriette Farkas, Dmitrijs Rots and Natalja Kurjane
    Citation: Allergy, Asthma & Clinical Immunology 2024 20:28
    Content type: Short report Published on:

  33. A significant update was made to both the Global Initiative for Asthma (GINA) in 2019 and the National Heart Lung and Blood Institute (NHLBI) asthma guidelines in 2020 for mild asthma. These groups no longer r...

    Authors: Beth A. Zerr, Jacklyn M. Kruse and Jon J. Glover
    Citation: Allergy, Asthma & Clinical Immunology 2024 20:27
    Content type: Research Published on:

  34. Hereditary alpha-tryptasemia (HαT) is an autosomal dominant disorder estimated to affect 5% of the population. High baseline tryptase level is a consistent finding, but there is a great variability of clinic m...

    Authors: Vicky Le Blanc and Wade T. A. Watson
    Citation: Allergy, Asthma & Clinical Immunology 2024 20:26
    Content type: Case report Published on:

  35. Systemic corticosteroid (SCS) use remains widespread among patients with severe asthma, despite associated complications.

    Authors: Thomas B Casale, Thomas Corbridge, Guillaume Germain, François Laliberté, Sean D MacKnight, Julien Boudreau, Mei S Duh and Arijita Deb
    Citation: Allergy, Asthma & Clinical Immunology 2024 20:25
    Content type: Research Published on:

  36. Asthma exacerbations are a leading cause of pediatric hospitalizations despite multiple efforts to educate patients and families on disease course and medication management. Asthma education in the pediatric e...

    Authors: Kina Goodman, Rosa I. Arriaga, Rawan Korman, Farzina Zafar, Cal Stephens, Polly Kumari, Karthika Jayaprakash, Anne M. Fitzpatrick, Nicholas Cooper and Claudia R. Morris
    Citation: Allergy, Asthma & Clinical Immunology 2024 20:24
    Content type: Letter to the editor Published on:

  37. Circular RNA (circRNA) has the potential to serve as a crucial regulator in the progression of bronchial asthma. The objective of this investigation was to elucidate the functional dynamics of the circ_0070934...

    Authors: Ziqi Ding, Xinru Xiao, Liang Fan, Zhengdao Mao, Chuang Sun, Na Li and Qian Zhang
    Citation: Allergy, Asthma & Clinical Immunology 2024 20:23
    Content type: Research Published on:

  38. The poly-sensitization to Hymenoptera venom makes it difficult to select genuine allergens for immunotherapy and increases patients’ costs. The objective of this study was to determine the culprit allergen in ...

    Authors: Mohammad Hassan Bemanian, Raheleh Shokouhi Shoormasti, Saba Arshi, Mahsa Jafari, Sima Shokri, Morteza Fallahpour, Mohammad Nabavi and Fatemeh Zaremehrjardi
    Citation: Allergy, Asthma & Clinical Immunology 2024 20:22
    Content type: Research Published on:

  39. While the impacts of atopic dermatitis (AD) on maternal and child sleep outcomes have been previously explored, less is known about the associations between infantile AD and sleep quality and quantity.

    Authors: Zoe Harbottle, Amanda Nötzel, Michael A. Golding, Manvir Bhamra, Isac Kopsch, Erik Wilking, Marina Jonsson, Elissa M. Abrams, Michelle A. Halbrich, Elinor Simons, Leslie E. Roos, Jill A. Keddy-Grant, Thomas V. Gerstner, Jo-Anne St-Vincent, Sandra Ekström and Jennifer L. P. Protudjer
    Citation: Allergy, Asthma & Clinical Immunology 2024 20:21
    Content type: Research Published on:

  40. Self-reported penicillin allergy labels are common and often inaccurate after assessment. These labels can lead to reduced use of first-line beta-lactam antibiotics and worse outcomes. We measured the impact o...

    Authors: Adhora Mir, Derek Lanoue, Veronica Zanichelli, Carl van Walraven, Timothy Olynych, Caroline Nott and Derek MacFadden
    Citation: Allergy, Asthma & Clinical Immunology 2024 20:20
    Content type: Research Published on:

  41. Eosinophilic gastritis (EoG) has rarely been reported in conjunction with gluten-sensitive enteropathy (GSE). When this does occur, patients typically present with gastrointestinal symptoms. To our knowledge, ...

    Authors: Zhirong Du, Zixi Wang, Weixun Zhou, Jia Yin and Yuxiang Zhi
    Citation: Allergy, Asthma & Clinical Immunology 2024 20:19
    Content type: Case report Published on:

  43. In this letter to the editor, we present questionnaire-based data assessing the patient journey of adults with moderate–severe Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) in the USA and five European cou...

    Authors: Jeremiah Hwee, Lauren Lee, Mark Small, Steven G. Smith, Victoria S. Benson and Shiyuan Zhang
    Citation: Allergy, Asthma & Clinical Immunology 2024 20:17
    Content type: Letter to the editor Published on:

  44. Correlations between mitochondrial DNA (mtDNA) and allergic rhinitis (AR) have not been reported before. This study aimed to better understand the mitochondrial genome profile with AR and to investigate the as...

    Authors: Huajie Yuan, Lingling Wang, Song Wang, Linge Li, Qingping Liu, Yan Wang, Yuping Yang and Hua Zhang
    Citation: Allergy, Asthma & Clinical Immunology 2024 20:16
    Content type: Research Published on:

  45. While a connection has been established between serum interleukin-6 (IL-6) levels and the IL-6 gene (− 174G/C) polymorphism in allergic diseases such as asthma, its specific association with severe asthma remains...

    Authors: Mona Al-Ahmad, Asmaa Ali, Ahmed Maher and Mohammad Z. Haider
    Citation: Allergy, Asthma & Clinical Immunology 2024 20:15
    Content type: Research Published on:

  46. Chronic Rhinosinusitis (CRS) is a paranasal sinus inflammatory disease and is divided into two subgroups defined as CRS with nasal polyps (CRSwNP) and CRS without nasal polyps (CRSsNP). CRSwNP displays a T hel...

    Authors: Javad Nazari, Faezeh Shahba, Negin Jafariaghdam, Saleh Mohebbi, Saba Arshi, Mohammad Hassan Bemanian, Morteza Fallahpour, Sima Shokri, Fatemeh Atashrazm, Saeed Amini, Maryam Roomiani, Mahnaz Jamee, Pegah Babaheidarian, Majid Khoshmirsafa and Mohammad Nabavi
    Citation: Allergy, Asthma & Clinical Immunology 2024 20:14
    Content type: Research Published on:

  48. According to the Th1/Th2 paradigm, the expansion of Th1-type clones in individuals with type 1 diabetes results in reduced Th2-type clones, preventing the development of atopic diseases and vice versa. However...

    Authors: Júlia Marchatto Kamei, Raissa Dias Maués, Gabriel de Oliveira Silva, Alessandra Helena Machado, Erika Megumi Hoshino, Fabiana Menezes Bacchiega, Laís Mota Furtado Sena and Carlos Antonio Negrato
    Citation: Allergy, Asthma & Clinical Immunology 2024 20:12
    Content type: Review Published on:

  49. Mepolizumab, the first widely available anti-interleukin 5 biologic, targets eosinophilic inflammation and has been shown in clinical trials to reduce exacerbations, oral corticosteroid dependence, and healthc...

    Authors: Kenneth R. Chapman, Kathryn Cogger, Erin Arthurs, Callahan LaForty, Shane Golden, Bradley Millson, Koyo Usuba and Christopher Licskai
    Citation: Allergy, Asthma & Clinical Immunology 2024 20:11
    Content type: Research Published on:

  50. Food protein-induced enterocolitis syndrome (FPIES) is a non-immunoglobulin E (IgE) -mediated food allergy predominantly observed in infants and characterized by the delayed onset of vomiting following ingesti...

    Authors: Hunter Hall, Sara Anvari, Fallon Schultz, Olubukola Ojuola and Nicholas L. Rider
    Citation: Allergy, Asthma & Clinical Immunology 2024 20:9
    Content type: Case report Published on:

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