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INSIDE in-beam positron emission tomography system for particle range monitoring in hadrontherapy
/ Bisogni, Maria Giuseppina (U. Pisa (main)) ; Attili, Andrea (U. Turin (main)) ; Battistoni, Giuseppe (INFN, Italy) ; Belcari, Nicola (U. Pisa (main)) ; Camarlinghi, Niccoló (U. Pisa (main)) ; Cerello, Piergiorgio (INFN, Italy) ; Coli, Silvia (INFN, Italy) ; Del Guerra, Alberto (U. Pisa (main)) ; Ferrari, Alfredo (CERN) ; Ferrero, Veronica (U. Turin (main)) et al.
The quality assurance of particle therapy treatment is a fundamental issue that can be addressed by developing reliable monitoring techniques and indicators of the treatment plan correctness. Among the available imaging techniques, positron emission tomography (PET) has long been investigated and then clinically applied to proton and carbon beams. [...]
2016 - 12 p.
- Published in : Journal of Medical Imaging 4 (2016) 011005
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2.
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Online monitoring for proton therapy: A real-time procedure using a planar PET system
/ Kraan, A C (Pisa U. ; INFN, Pisa) ; Battistoni, G (INFN, Milan) ; Belcari, N (Pisa U. ; INFN, Pisa) ; Camarlinghi, N (Pisa U. ; INFN, Pisa) ; Ciocca, M (CNAO, Pavia) ; Ferrari, A (CERN) ; Ferretti, S (Pisa U. ; INFN, Pisa) ; Mairani, A (CNAO, Pavia) ; Molinelli, S (CNAO, Pavia) ; Pullia, M (CNAO, Pavia) et al.
In this study a procedure for range verification in proton therapy by means of a planar in-beam PET system is presented. The procedure consists of two steps: the measurement of the β+-activity induced in the irradiated body by the proton beam and the comparison of these distributions with simulations. [...]
2015
- Published in : Nucl. Instrum. Methods Phys. Res., A 786 (2015) 120-126
Elsevier Open Access article: PDF;
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3.
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Monitoring Proton Therapy Through in-Beam PET: An Experimental Phantom Study
/ Topi, A (INFN, Pisa) ; Muraro, S (INFN, Pisa) ; Battistoni, G (INFN, Milan) ; Belcari, N (INFN, Pisa ; Pisa U.) ; Bisogni, M G (INFN, Pisa ; Pisa U.) ; Camarlinghi, N (INFN, Pisa ; Pisa U.) ; Del Guerra, A (INFN, Pisa ; Pisa U.) ; Ferrari, A (CERN) ; Kopec, R (Cracow, INP) ; Kraan, A C (INFN, Pisa) et al.
In this paper, we investigate the use of a positron
emission tomography (PET) system to monitor the proton therapy. The monitoring procedure is based on the comparison
between the β+ activity generated in the irradiated volume during the treatment, with the β+ activity distribution obtained
with Monte Carlo (MC) simulation. [...]
2020 - 8 p.
- Published in : IEEE Trans. Rad. Plasma Med. Sci. 4 (2020) 194-201
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4.
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An overview of recent developments in FLUKA PET tools
/ Augusto, R S (CERN ; LMU Munich (main)) ; Bauer, J (Heidelberg U. Hospital) ; Bouhali, O (Texas A&M; U. Qatar, Doha) ; Cuccagna, C (CERN ; TERA, Novara ; U. Geneva (main)) ; Gianoli, C (LMU Munich (main)) ; Kozłowska, W S (CERN ; Med. U. of Vienna, Spitalgasse) ; Ortega, P G (U. Salamanca (main)) ; Tessonnier, T (Centre François Baclesse, Caen) ; Toufique, Y (Texas A&M; U. Qatar, Doha ; Hassan 1st U., Settat) ; Vlachoudis, V (CERN) et al.
The new developments of the FLUKA Positron-Emission-Tomography (PET) tools are detailed. FLUKA is a fully integrated Monte Carlo (MC) particle transport code, used for an extended range of applications, including Medical Physics. [...]
2018
- Published in : Physica Medica 54 (2018) 189-199
Fulltext: PDF;
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5.
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The associative memory for the self-triggered SLIM5 silicon telescope
/ Batignani, G (U. Pisa (main) ; INFN, Pisa) ; Bettarini, S (U. Pisa (main) ; INFN, Pisa) ; Calderini, G (U. Pisa (main) ; INFN, Pisa) ; Cenci, R (U. Pisa (main) ; INFN, Pisa) ; Cervelli, A (U. Pisa (main) ; INFN, Pisa) ; Crescioli, F (U. Pisa (main) ; INFN, Pisa) ; Dell'Orso, M (U. Pisa (main) ; INFN, Pisa) ; Forti, F (U. Pisa (main) ; INFN, Pisa) ; Giannetti, P (INFN, Pisa) ; Giorgi, M A (U. Pisa (main) ; INFN, Pisa) et al.
Modern experiments search for extremely rare processes hidden in much larger background levels. As the experiment complexity, the accelerator backgrounds and luminosity increase we need increasingly exclusive selections to efficiently select the rare events inside the huge background. [...]
2009 - 5 p.
- Published in : 10.1109/NSSMIC.2008.4774945
In : 2008 IEEE Nuclear Science Symposium, Medical Imaging Conference and 16th Room Temperature Semiconductor Detector Workshop, Dresden, Germany, 19 - 25 Oct 2008, pp.2765-2769
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6.
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Proton therapy treatment monitoring with the DoPET system: activity range, positron emitters evaluation and comparison with Monte Carlo predictions
/ Muraro, S (Pisa U. ; INFN, Pisa) ; Battistoni, G (INFN, Milan) ; Belcari, N (Pisa U. ; INFN, Pisa) ; Bisogni, M G (Pisa U. ; INFN, Pisa) ; Camarlinghi, N (Pisa U. ; INFN, Pisa) ; Cristoforetti, L (Trento Hospital, Trento) ; Guerra, A Del (Pisa U. ; INFN, Pisa) ; Ferrari, A (CERN) ; Fracchiolla, F (Trento Hospital, Trento) ; Morrocchi, M (Pisa U. ; INFN, Pisa) et al.
Ion beam irradiations can deliver conformal dose distributions minimizing damage to healthy tissues thanks to their characteristic dose profiles. Nevertheless, the location of the Bragg peak can be affected by different sources of range uncertainties: a critical issue is the treatment verification. [...]
2017 - 10 p.
- Published in : JINST 12 (2017) C12026
In : 19th International Workshop on Radiation Imaging Detectors, Krakow, Poland, 2 - 6 Jul 2017, pp.C12026
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7.
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8.
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Performance of the reconstruction algorithms of the FIRST experiment pixel sensors vertex detector
/ Rescigno, R (Strasbourg, IPHC) ; Finck, Ch (Strasbourg, IPHC) ; Juliani, D (Strasbourg, IPHC) ; Spiriti, E (Frascati ; INFN, Rome3) ; Baudot, J (Strasbourg, IPHC) ; Abou-Haidar, Z (CNA, Seville) ; Agodi, C (INFN, LNS) ; Alvarez, M A G (CNA, Seville) ; Aumann, T (Darmstadt, GSI) ; Battistoni, G (INFN, Milan) et al.
Hadrontherapy treatments use charged particles (e.g. protons and carbon ions) to treat tumors. [...]
2014 - 7 p.
- Published in : Nucl. Instrum. Methods Phys. Res., A 767 (2014) 34-40
Elsevier Open Access article: PDF;
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9.
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Low statistics positron activity reconstruction methods for proton therapy
/ Muraro, S (Pisa U. ; INFN, Pisa) ; Camarlinghi, N (Pisa U. ; INFN, Pisa) ; Battistoni, G (INFN, Milan) ; Belcari, N (Pisa U. ; INFN, Pisa) ; Bisogni, M G (INFN, Pisa ; Pisa U.) ; Cristoforetti, L (Unlisted, IT) ; Del Guerra, A (Pisa U. ; INFN, Pisa) ; Ferrari, A (CERN) ; Fracchiolla, F (Unlisted, IT) ; Kraan, A (Pisa U. ; INFN, Pisa) et al.
Positron emission tomography (PET) is one of the most mature techniques for monitoring in ion beam therapy. PET allows to reconstruct the β$^{+}$ activity generated in the patient by the nuclear interaction of the ions. [...]
2019 - 2 p.
- Published in : Nucl. Instrum. Methods Phys. Res., A 936 (2019) 52-53
In : Frontier Detectors for Frontier Physics: XIV Pisa Meeting on Advanced Detectors, La Biodola, Isola D'elba, Italy, 27 May - 2 Jun 2018, pp.52-53
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10.
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The use of multi-gap resistive plate chambers for in-beam PET in proton and carbon ion therapy
/ Watts, David (TERA, Novara ; Barcelona, Autonoma U.) ; Borghi, Giacomo (TERA, Novara) ; Sauli, Fabio (TERA, Novara) ; Amaldi, Ugo (TERA, Novara)
On-line verification of the delivered dose during proton and carbon ion radiotherapy is currently a very desirable goal for quality assurance of hadron therapy treatment plans. In-beam positron emission tomography (ibPET), which can provide an image of the β+ activity induced in the patient during irradiation, which in turn is correlated to the range of the ion beam, is one of the modalities for achieving this goal. [...]
2013
- Published in : J. Radiat. Res. 54 (2013) i136-i142
Oxford Univ. Press Open Access article: PDF;
In : PARTNER, pp.i136-i142
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