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1.
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ENLIGHT (European Network for Light Ion Hadron Therapy) and its role in Hadron therapy
/ Georgieva, Petya (CERN) ; Dosanjh, Manjit (CERN ; Oxford U.)
Purpose
This study provides a comprehensive overview of the progress in hadron therapy within Europe, particularly highlighting the critical roles of the Proton Ion Medical Machine Study (PIMMS) and the European Network for Light Ion Hadron Therapy (ENLIGHT).
Methods
Our approach includes a retrospective analysis of the advances in hadron therapy facilities, facilitated by a synthesis of interdisciplinary collaboration data gathered from ENLIGHT's annual meetings since 2002, and an assessment of European-funded projects and networks' contributions to the field.
Results
The results showcase significant advancements in cancer treatment due to collective efforts in hadron therapy, underscored by ENLIGHT’s pivotal role in fostering interdisciplinary cooperation and the harmonization of treatment protocols across Europe.
Conclusion
The evolution of hadron therapy, from its inception to its current impact on patient care, demonstrates the successful realization of complex medical technologies through sustained collaboration and standardized practices across European institutions and projects..
2024 - 7 p.
- Published in : Health Technol. 14 (2024) 833-839
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Active dosimetry for VHEE FLASH radiotherapy using beam profile monitors and charge measurements
/ Rieker, Vilde F (CERN ; Oslo U.) ; Corsini, Roberto (CERN) ; Stapnes, Steinar (CERN) ; Adli, Erik (Oslo U.) ; Farabolini, Wilfrid (CERN) ; Grilj, Veljko (SUBATECH, Nantes) ; Sjobak, Kyrre N (Oslo U.) ; Wroe, Laurence M (CERN) ; Aksoy, Avni (CERN ; Ankara U.) ; Robertson, Cameron S (Oxford U.) et al.
The discovery of the FLASH effect has revealed a high potential for treating cancer more efficiently by sparing
healthy tissue. The surge in related medical research activities over the last couple of years has triggered a
demand for technology with the capability of generating and measuring ionizing radiation at ultra-high doserates (UHDR). [...]
2024 - 12 p.
- Published in : Nucl. Instrum. Methods Phys. Res., A 1069 (2024) 169845
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3.
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“Particle therapy - future for the Baltic states?” – synthesis of the expert workshop report
/ Paļskis, Kristaps (Riga Tech. U. ; CERN) ; Korobeinikova, Erika ; Bogorada-Saukuma, Dace ; Camarda, Anna Maria (CNAO, Milan) ; Taylor, Rebecca (CERN ; Imperial Coll., London) ; Benedetto, Elena ; Mamis, Edgars (CERN ; Latvia U.) ; Radziņa, Maija ; Ērglis, Andrejs (Latvia U.) ; Adliene, Diana et al.
Background Baltic States remains one of the few regions in the Europe without a dedicated particle therapy center. An initiative since 2021 has been started by CERN Baltic Group on a novel particle therapy center development in the region in partnership with CERN NIMMS collaboration. [...]
2024 - 8 p.
- Published in : Health Technol. 14 (2024) 965-972
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4.
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Plastic Scintillator Dosimetry of Ultrahigh Dose-Rate 200 MeV Electrons at CLEAR
/ Hart, Alexander (Victoria U.) ; Giguère, Cloé (Laval U.) ; Bateman, Joseph (Oxford U.) ; Korysko, Pierre (Oxford U.) ; Farabolini, Wilfrid (CERN) ; Rieker, Vilde (CERN ; Oslo U.) ; Esplen, Nolan (Victoria U.) ; Corsini, Roberto (CERN) ; Dosanjh, Manjit (Oxford U.) ; Beaulieu, Luc (Laval U.) et al.
Very-high-energy electron (VHEE) beams with energies greater than 100 MeV may be promising candidates for FLASH radiotherapy due to their favorable dose distributions and accessibility of ultrahigh dose rates (UHDRs). Combining VHEE with the normal tissue-sparing FLASH effect of UHDR radiotherapy could improve patient outcomes. [...]
2024 - 9 p.
- Published in : IEEE Sensors J. 24 (2024) 14229-14237
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5.
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Mini-GRID radiotherapy on the CLEAR very-high-energy electron beamline: collimator optimization, film dosimetry, and Monte Carlo simulations
/ Clements, Nathan (Victoria U.) ; Esplen, Nolan (Victoria U.) ; Bateman, Joseph (Oxford U.) ; Robertson, Cameron (Oxford U.) ; Dosanjh, Manjit (Oxford U. ; CERN) ; Korysko, Pierre (Oxford U. ; CERN) ; Farabolini, Wilfrid (CERN) ; Corsini, Roberto (CERN) ; Bazalova-Carter, Magdalena (Victoria U.)
Objective. Spatially-fractionated radiotherapy (SFRT) delivered with a very-high-energy electron (VHEE) beam and a mini-GRID collimator was investigated to achieve synergistic normal tissue-sparing through spatial fractionation and the FLASH effect. [...]
2024 - 17 p.
- Published in : Phys. Med. Biol. 69 (2024) 055003
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6.
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A novel fibre optic monitor for VHEE UHDR beam monitoring: first tests at CLEAR
/ Bateman, Joseph (JAI, UK ; CERN) ; Buchanan, Emma (CERN) ; Corsini, Roberto (CERN) ; Gerbershagen, Alexander (Groningen U.) ; Ortega Ruiz, Inaki (CERN) ; Dosanjh, Manjit (JAI, UK ; CERN) ; Farabolini, Wilfrid (CERN) ; Rieker, Vilde (CERN ; Oslo U.) ; Korysko, Pierre (JAI, UK ; CERN) ; Malyzhenkov, Alexander (CERN)
Beam monitoring for Ultra High Dose Rate (UHDR) radiation therapy using pulsed beams, i.e. Very High Energy Electrons (VHEE), is a major challenge. [...]
2023
- Published in : JACoW IPAC 2023 (2023) THPL041
Fulltext: PDF;
In : 14th International Particle Accelerator Conference (IPAC 2023), Venice, Italy, 7 - 12 May 2023, pp.THPL041
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7.
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8.
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Improving access to radiotherapy in LMICs through a collaborative initiative to reduce technology downtime
/ Ige, Taofeeq A (Natl. Hospital Abuja, Nigeria ; Lancaster U.) ; Jenkins, Alexander (Lancaster U. ; Oxford U.) ; Dosanjh, Manjit (Lancaster U. ; Oxford U. ; Internatl. Cancer Expert Corps, Washington) ; O’Brien, Donna (Internatl. Cancer Expert Corps, Washington) ; Pistenmaa, David (Lancaster U. ; Internatl. Cancer Expert Corps, Washington) ; Coleman, C Norman (Internatl. Cancer Expert Corps, Washington)
This chapter covers approaches that aim to increase access to radiotherapy care in Africa by reducing machine downtime. It includes a survey design covering this issue across Africa..
2022 - 10 p.
- Published in : 10.1088/978-0-7503-3075-6ch21
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9.
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Understanding the challenges of delivering radiotherapy in low- and middle-income countries in Africa
/ Ige, Taofeeq (Nigeria U.) ; Lewis, Philippa (JAI, UK) ; Shelley, Charlotte (U. Manchester (main)) ; Pistenmaa, David ; Coleman, C Norman ; Aggarwal, Ajay (King's Coll. London) ; Dosanjh, Manjit (CERN ; Oxford U.)
Background
Access to high quality radiotherapy (RT) continues to be a major issue across Africa with Africa having just 34% of its optimal capacity.
Methods
We co-developed a survey with clinical, academic and policy stakeholders designed to provide a structured assessment of the barriers and enablers to RT capacity building in Africa. The survey covered nine key themes including funding, procurement, education and training. [...]
2023 - 8 p.
- Published in : Journal of Cancer Policy 35 (2023) 100372
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10.
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Minimising Transverse Multipoles in Accelerating RF Cavities via Azimuthally Modulated Designs
/ Wroe, Laurence (JAI, UK) ; Apsimon, Robert (Lancaster U. (main)) ; Dosanjh, Manjit (CERN) ; Sheehy, Suzanne (Melbourne U.)
In this paper, we build upon previous work of designing RF structures that support modes with tailored multipolar fields by applying the concept to negate the transverse multipoles in accelerating RF cavities caused by the incorporation of waveguide slots and tuning deformations. We outline a systematic method for designing structures that minimise these transverse multipoles and present analysis of simulations of two different minimisation designs..
2022 - 4 p.
- Published in : JACoW IPAC 2022 (2022) 610-613
Fulltext: PDF;
In : 13th International Particle Accelerator Conference (IPAC 2022), Bangkok, Thailand, 12 - 17 Jun 2022, pp.610-613
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