CERN Accelerating science

Preprint
Report number	E19-2005-112 ; JINR-E19-2005-112
Title	Combining Different Modalities for 3D Imaging of Biological Objects
Author(s)	Tsyganov, E ; Antich, P ; Kulkarni, P ; Mason, R ; Parkey, R ; Seliuonine, S ; Shay, J ; Soesbe, T ; Zhezher, V ; Zinchenko, A I
Affiliation	(The University of Texas Southwestern Medical Center, Dallas, USA) ; (Veksler and Baldin Laboratory of High Energies, Dubna)
Publication	2005
Imprint	19 Jul 2005
Number of pages	17
Subject category	Other Fields of Physics
Abstract	A resolution enhanced NaI(Tl)-scintillator micro-SPECT device using pinhole collimator geometry has been built and tested with small animals. This device was constructed based on a depth-of-interaction measurement using a thick scintillator crystal and a position sensitive PMT to measure depth-dependent scintillator light profiles. Such a measurement eliminates the parallax error that degrades the high spatial resolution required for small animal imaging. This novel technique for 3D gamma-ray detection was incorporated into the micro-SPECT device and tested with a $^{57}$Co source and $^{98m}$Tc-MDP injected in mice body. To further enhance the investigating power of the tomographic imaging different imaging modalities can be combined. In particular, as proposed and shown in this paper, the optical imaging permits a 3D reconstruction of the animal's skin surface thus improving visualization and making possible depth-dependent corrections, necessary for bioluminescence 3D reconstruction in biological objects. This structural information can provide even more detail if the x-ray tomography is used as presented in the paper.
Submitted by	[email protected]