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Sp8转录因子

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Sp8转录因子
识别号
别名SP8;, BTD, Sp8 transcription factor
外部IDOMIM608306 MGI2443471 HomoloGene18548 GeneCardsSP8
基因位置(人类
7号染色体
染色体7号染色体[1]
7号染色体
Sp8转录因子的基因位置
Sp8转录因子的基因位置
基因座7p21.1起始20,782,279 bp[1]
终止20,786,886 bp[1]
直系同源
物种人类小鼠
Entrez
Ensembl
UniProt
mRNA​序列

NM_182700
​NM_198956

NM_177082
​NM_001379379
​NM_001379380

蛋白序列

NP_874359
​NP_945194

NP_796056
​NP_001366308
​NP_001366309

基因位置​(UCSC)Chr 7: 20.78 – 20.79 MbChr 12: 118.81 – 118.82 Mb
PubMed​查找[3][4]
维基数据
查看/编辑人类查看/编辑小鼠

Sp8转录因子又称为特异性蛋白8(specificity protein 8、SP-8)或Btd转录因子[5]是由SP8基因编码的人类蛋白质[6][7],位于人类的7号染色体中。Sp8是Sp/KLF家族转录因子

功能

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Sp8在肢体生长早起扮演了协调的作用。[5]在小鼠实验中,若小鼠缺失Sp8基因会导致严重的脑外畸形英语Exencephaly[8]

参考文献

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  1. ^ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000164651 - Ensembl, May 2017
  2. ^ 2.0 2.1 2.2 GRCm38: Ensembl release 89: ENSMUSG00000048562 - Ensembl, May 2017
  3. ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  4. ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  5. ^ 5.0 5.1 Treichel D, Schöck F, Jäckle H, Gruss P, Mansouri A. mBtd is required to maintain signaling during murine limb development (PDF). Genes & Development. November 2003, 17 (21): 2630–5 [2024-01-28]. PMC 280612可免费查阅. PMID 14597661. doi:10.1101/gad.274103. (原始内容存档 (PDF)于2017-09-22). 
  6. ^ Bell SM, Schreiner CM, Waclaw RR, Campbell K, Potter SS, Scott WJ. Sp8 is crucial for limb outgrowth and neuropore closure. Proceedings of the National Academy of Sciences of the United States of America. October 2003, 100 (21): 12195–200. PMC 218735可免费查阅. PMID 14526104. doi:10.1073/pnas.2134310100可免费查阅. 
  7. ^ Entrez Gene: Sp8 transcription factor. 
  8. ^ Waclaw RR, Allen ZJ, Bell SM, Erdélyi F, Szabó G, Potter SS, Campbell K. The zinc finger transcription factor Sp8 regulates the generation and diversity of olfactory bulb interneurons. Neuron. February 2006, 49 (4): 503–16. PMID 16476661. S2CID 17734218. doi:10.1016/j.neuron.2006.01.018可免费查阅. 

延伸阅读

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