You can divide large numbers in python as you would normally do. But this has a lot of precision issues as such operations cannot be guaranteed to be precise as it might slow down the language. You would be better off using a numeric computation library like bigfloat to perform such operations.
You can read more about floating point issues that you might face with precision on https://docs.python.org/3/tutorial/floatingpoint.html