Twist family bHLH transcription factor 1 (Q575849)

http://www.ebi.ac.uk/interpro/protein/Q15672

http://www.ebi.ac.uk/interpro/protein/H7C4D7

Helix-loop-helix DNA-binding domain superfamily

2 references

http://www.ebi.ac.uk/interpro/protein/Q15672

http://www.ebi.ac.uk/interpro/protein/H7C4D7

Myc-type, basic helix-loop-helix (bHLH) domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

2 references

13 November 2019

17 September 2016

2 references

13 November 2019

20 March 2016

language of work or name

English

molecular function

DNA binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

1 reference

8 April 2019

protein homodimerization activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

protein domain specific binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

DNA-binding transcription factor activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

bHLH transcription factor binding

1 reference

8 April 2019

Saethre-Chotzen mutations cause TWIST protein degradation or impaired nuclear location

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

E-box binding

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

8 April 2019

Twist transcriptionally up-regulates AKT2 in breast cancer cells leading to increased migration, invasion, and resistance to paclitaxel

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

8 April 2019

Twist1 promotes heart valve cell proliferation and extracellular matrix gene expression during development in vivo and is expressed in human diseased aortic valves

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

protein binding

8 references

8 April 2019

Induction of EMT by twist proteins as a collateral effect of tumor-promoting inactivation of premature senescence

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

8 April 2019

SET8 promotes epithelial-mesenchymal transition and confers TWIST dual transcriptional activities

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

8 April 2019

Twist and p53 reciprocally regulate target genes via direct interaction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

8 April 2019

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

8 April 2019

In silico prediction of physical protein interactions and characterization of interactome orphans

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

8 April 2019

Disrupting the interaction of BRD4 with diacetylated Twist suppresses tumorigenesis in basal-like breast cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

8 April 2019

A "twist box" code of p53 inactivation: twist box: p53 interaction promotes p53 degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

8 April 2019

Matrix stiffness drives epithelial-mesenchymal transition and tumour metastasis through a TWIST1-G3BP2 mechanotransduction pathway.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

protein heterodimerization activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

DNA-binding transcription factor activity, RNA polymerase II-specific

A census of human transcription factors: function, expression and evolution

4 references

8 April 2019

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

8 April 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

Norwegian University of Science and Technology, Systems Biology team

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

ISA

8 April 2019

Twist transcriptionally up-regulates AKT2 in breast cancer cells leading to increased migration, invasion, and resistance to paclitaxel

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

cell component

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

4 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

8 April 2019

HOXA5-twist interaction alters p53 homeostasis in breast cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

8 April 2019

Saethre-Chotzen mutations cause TWIST protein degradation or impaired nuclear location

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

nucleoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

1 reference

8 April 2019

positive regulation of transcription regulatory region DNA binding

biological process

1 reference

8 April 2019

TWIST inactivation reduces CBFA1/RUNX2 expression and DNA binding to the osteocalcin promoter in osteoblasts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

embryonic skeletal system morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

positive regulation of fatty acid beta-oxidation

1 reference

8 April 2019

A possible inflammatory role of twist1 in human white adipocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

roof of mouth development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

positive regulation of cell motility

Twist and epithelial-mesenchymal transition are induced by the EBV oncoprotein latent membrane protein 1 and are associated with metastatic nasopharyngeal carcinoma

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

8 April 2019

Twist transcriptionally up-regulates AKT2 in breast cancer cells leading to increased migration, invasion, and resistance to paclitaxel

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

regulation of transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15672&geneProductId=UniProtKB:Q15672

1 reference

27 March 2018

negative regulation of molecular function

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

rhythmic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

1 reference

8 April 2019

positive regulation of epithelial cell proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

negative regulation of striated muscle tissue development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

regulation of bone mineralization

1 reference

8 April 2019

Association of TWIST1 gene polymorphisms with bone mineral density in postmenopausal women

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

aortic valve morphogenesis

Twist1 promotes heart valve cell proliferation and extracellular matrix gene expression during development in vivo and is expressed in human diseased aortic valves

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

negative regulation of cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

cardiac neural crest cell migration involved in outflow tract morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

cellular response to growth factor stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

positive regulation of monocyte chemotactic protein-1 production

1 reference

8 April 2019

A possible inflammatory role of twist1 in human white adipocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

muscle organ development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

1 reference

8 April 2019

negative regulation of apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

neuron migration

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

in utero embryonic development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

outer ear morphogenesis

1 reference

8 April 2019

The sonic hedgehog-patched-gli pathway in human development and disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

eyelid development in camera-type eye

1 reference

8 April 2019

Ocular phenotype correlations in patients with TWIST versus FGFR3 genetic mutations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

mitral valve morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

positive regulation of DNA-templated transcription, initiation

1 reference

8 April 2019

Twist transcriptionally up-regulates AKT2 in breast cancer cells leading to increased migration, invasion, and resistance to paclitaxel

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

negative regulation of DNA-binding transcription factor activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15672&geneProductId=UniProtKB:Q15672

1 reference

27 March 2018

positive regulation of angiogenesis

1 reference

8 April 2019

Up-regulation of Twist induces angiogenesis and correlates with metastasis in hepatocellular carcinoma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

hindlimb morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

negative regulation of phosphatidylinositol 3-kinase signaling

1 reference

8 April 2019

Down-regulation of ubiquitin ligase Cbl induced by twist haploinsufficiency in Saethre-Chotzen syndrome results in increased PI3K/Akt signaling and osteoblast proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

odontogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

endocardial cushion morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

negative regulation of double-strand break repair

1 reference

8 April 2019

Role of p14ARF in TWIST-mediated senescence in prostate epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

multicellular organism development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

1 reference

8 April 2019

cardiac neural crest cell development involved in outflow tract morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

neural tube closure

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

positive regulation of gene expression

1 reference

8 April 2019

Down-regulation of ubiquitin ligase Cbl induced by twist haploinsufficiency in Saethre-Chotzen syndrome results in increased PI3K/Akt signaling and osteoblast proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

negative regulation of DNA damage response, signal transduction by p53 class mediator

1 reference

8 April 2019

Role of p14ARF in TWIST-mediated senescence in prostate epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

negative regulation of skeletal muscle tissue development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

embryonic limb morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

negative regulation of oxidative phosphorylation uncoupler activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

osteoblast differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

positive regulation of tumor necrosis factor production

1 reference

8 April 2019

A possible inflammatory role of twist1 in human white adipocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

cell proliferation involved in heart valve development

Twist1 promotes heart valve cell proliferation and extracellular matrix gene expression during development in vivo and is expressed in human diseased aortic valves

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

embryonic cranial skeleton morphogenesis

Mutations of the TWIST gene in the Saethre-Chotzen syndrome

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

8 April 2019

Mutations in TWIST, a basic helix-loop-helix transcription factor, in Saethre-Chotzen syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

negative regulation of tumor necrosis factor production

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

negative regulation of peroxisome proliferator activated receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

negative regulation of histone acetylation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

embryonic camera-type eye formation

1 reference

8 April 2019

Ocular phenotype correlations in patients with TWIST versus FGFR3 genetic mutations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

bone development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

embryonic forelimb morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

positive regulation of transcription by RNA polymerase II

TWIST inactivation reduces CBFA1/RUNX2 expression and DNA binding to the osteocalcin promoter in osteoblasts

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

8 April 2019

Twist transcriptionally up-regulates AKT2 in breast cancer cells leading to increased migration, invasion, and resistance to paclitaxel

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

negative regulation of cellular senescence

1 reference

8 April 2019

Role of p14ARF in TWIST-mediated senescence in prostate epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

embryonic hindlimb morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

negative regulation of transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

3 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

8 April 2019

Functional Analysis of Two Novel Mutations in TWIST1 Protein Motifs Found in Ventricular Septal Defect Patients

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

cytokine-mediated signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672

1 reference

8 April 2019

http://purl.uniprot.org/uniprot/Q15672

Gene Atlas image

PBB GE TWIST1 213943 at fs.png
732 × 530; 11 KB

0 references

exact match

1 reference

Myc-type, basic helix-loop-helix (bHLH) domain

Identifiers.org

has part(s)

2 references

http://www.ebi.ac.uk/interpro/protein/Q15672

http://www.ebi.ac.uk/interpro/protein/H7C4D7

Identifiers

MeSH descriptor ID

D051879

subject named as

Twist-Related Protein 1

0 references

MeSH tree code

D12.776.260.103.906.250

0 references

D12.776.930.125.906.250

0 references

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

20 March 2016

language of work or name

1 reference

1 reference

1 reference

0 references

Microsoft Academic ID

0 references

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

1 reference

20 March 2016

language of work or name

1 reference

inferred by common MeSH mappings on source and on Wikidata

UMLS 2023