CD22 molecule (Q5009798)

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mammalian protein found in Homo sapiens

BL-CAM
sialic acid-binding Ig-like lectin 2
CD22
B-lymphocyte cell adhesion molecule
B-cell receptor CD22
CD22 antigen
T-cell surface antigen Leu-14
Siglec-2

Language	Label	Description	Also known as
English	CD22 molecule	mammalian protein found in Homo sapiens	BL-CAM sialic acid-binding Ig-like lectin 2 CD22 B-lymphocyte cell adhesion molecule B-cell receptor CD22 CD22 antigen T-cell surface antigen Leu-14 Siglec-2

Statements

1 reference

13 November 2019

UniProt protein ID

Immunoglobulin-like fold

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P20273

Immunoglobulin-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P20273

Immunoglobulin subtype, protein family

1 reference

based on heuristic

inferred from protein domain or family

CD80-like, immunoglobulin C2-set, protein family

1 reference

based on heuristic

inferred from protein domain or family

Immunoglobulin subtype 2, protein family

1 reference

based on heuristic

inferred from protein domain or family

immunoglobulin-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

protein binding

determination method or standard

2 references

8 April 2019

CD22 associates with protein tyrosine phosphatase 1C, Syk, and phospholipase C-gamma(1) upon B cell activation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20273

determination method or standard

8 April 2019

Involvement of p72syk kinase, p53/56lyn kinase and phosphatidyl inositol-3 kinase in signal transduction via the human B lymphocyte antigen CD22

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20273

determination method or standard

carbohydrate binding

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20273

determination method or standard

determination method or standard

1 reference

8 April 2019

Cell surface sialic acids do not affect primary CD22 interactions with CD45 and surface IgM nor the rate of constitutive CD22 endocytosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20273

determination method or standard

signaling receptor binding

determination method or standard

1 reference

8 April 2019

Cell surface sialic acids do not affect primary CD22 interactions with CD45 and surface IgM nor the rate of constitutive CD22 endocytosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20273

determination method or standard

CD4 receptor binding

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20273

determination method or standard

integral component of membrane

determination method or standard

1 reference

26 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20273&geneProductId=UniProtKB:P20273

determination method or standard

plasma membrane

determination method or standard

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20273

determination method or standard

8 April 2019

Cell surface sialic acids do not affect primary CD22 interactions with CD45 and surface IgM nor the rate of constitutive CD22 endocytosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20273

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20273

determination method or standard

extracellular exosome

determination method or standard

1 reference

26 September 2017

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20273&geneProductId=UniProtKB:P20273

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20273

determination method or standard

determination method or standard

1 reference

8 April 2019

Cell surface sialic acids do not affect primary CD22 interactions with CD45 and surface IgM nor the rate of constitutive CD22 endocytosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20273

determination method or standard

determination method or standard

1 reference

8 April 2019

Distinct endocytic mechanisms of CD22 (Siglec-2) and Siglec-F reflect roles in cell signaling and innate immunity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20273

determination method or standard

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20273

determination method or standard

neuronal cell body membrane

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20273

determination method or standard

recycling endosome

determination method or standard

1 reference

8 April 2019

Distinct endocytic mechanisms of CD22 (Siglec-2) and Siglec-F reflect roles in cell signaling and innate immunity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20273

determination method or standard

extracellular exosome

determination method or standard

1 reference

8 April 2019

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20273

determination method or standard

biological process

regulation of endocytosis

determination method or standard

1 reference

8 April 2019

Distinct endocytic mechanisms of CD22 (Siglec-2) and Siglec-F reflect roles in cell signaling and innate immunity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20273

determination method or standard

regulation of B cell proliferation

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20273

determination method or standard

B cell activation

determination method or standard

1 reference

8 April 2019

MicroRNA-19a and CD22 Comprise a Feedback Loop for B Cell Response in Sepsis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20273

determination method or standard

regulation of immune response

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20273

determination method or standard

negative regulation of calcium-mediated signaling

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20273

determination method or standard

negative regulation of B cell receptor signaling pathway

determination method or standard

3 references

8 April 2019

Cell surface sialic acids do not affect primary CD22 interactions with CD45 and surface IgM nor the rate of constitutive CD22 endocytosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20273

determination method or standard

8 April 2019

The Myc-miR-17-92 axis amplifies B-cell receptor signaling via inhibition of ITIM proteins: a novel lymphomagenic feed-forward loop.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20273

determination method or standard

8 April 2019

MicroRNA-19a and CD22 Comprise a Feedback Loop for B Cell Response in Sepsis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20273

determination method or standard

Gene Atlas image

PBB GE CD22 38521 at fs.png
732 × 530; 11 KB

0 references

http://purl.uniprot.org/uniprot/P20273

1 reference

Identifiers.org

Commons category

CD22

0 references

Identifiers

MeSH descriptor ID

subject named as

Sialic Acid Binding Ig-like Lectin 2

0 references

D09.400.430.890.200.810

0 references

D12.776.395.550.200.810

0 references

D12.776.503.921.200

0 references

D12.776.543.550.200.810

0 references

D23.050.301.350.720

0 references

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000085219

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000085219

ENSP00000339349

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000339349

ENSP00000403822

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000403822

ENSP00000441237

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000441237

ENSP00000442279

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000442279

ENSP00000469984

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000469984

ENSP00000469503

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000469503

ENSP00000469523

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000469523

ENSP00000469980

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000469980

ENSP00000470193

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000470193

ENSP00000470681

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000470681

ENSP00000470724

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000470724

ENSP00000471399

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000471399

ENSP00000471972

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000471972

ENSP00000472664

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000472664

ENSP00000472762

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000472762

ENSP00000473221

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000473221

ENSP00000482823

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000482823

0 references

Microsoft Academic ID

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

Wikipedia(9 entries)

dewiki B-Zell-Rezeptor CD22
enwiki CD22
fawiki CD22
frwiki CD22
ruwiki CD22
ttwiki CD22
ukwiki CD22
viwiki CD22
zhwiki CD22

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(1 entry)

commonswiki Category:CD22

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