Activin A receptor type 2A (Q4650906)

http://www.ebi.ac.uk/interpro/protein/P27037

TGFβ superfamily receptor

1 reference

http://www.ebi.ac.uk/interpro/protein/P27037

activin types I and II receptor domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Serine/threonine-protein kinase, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27037

1 reference

8 April 2019

nucleotide binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27037

1 reference

8 April 2019

protein kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27037

1 reference

8 April 2019

PDZ domain binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27037

growth factor binding

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27037&geneProductId=UniProtKB:P27037

coreceptor activity

1 reference

8 April 2019

Betaglycan binds inhibin and can mediate functional antagonism of activin signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27037

activin binding

Activin and inhibin have antagonistic effects on ligand-dependent heteromerization of the type I and type II activin receptors and human erythroid differentiation

2 references

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27037&geneProductId=UniProtKB:P27037

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27037&geneProductId=UniProtKB:P27037

metal ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27037

1 reference

8 April 2019

kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27037

1 reference

8 April 2019

protein self-association

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27037

protein serine/threonine kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27037

3 references

8 April 2019

8 April 2019

Activation of signalling by the activin receptor complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27037

EXP

8 April 2019

Formation and activation by phosphorylation of activin receptor complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27037

EXP

inhibin binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27037

protein binding

7 references

8 April 2019

Modulation of activin signal transduction by inhibin B and inhibin-binding protein (INhBP)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27037

8 April 2019

Activin and inhibin have antagonistic effects on ligand-dependent heteromerization of the type I and type II activin receptors and human erythroid differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27037

8 April 2019

Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27037

8 April 2019

Activin and inhibin have antagonistic effects on ligand-dependent heteromerization of the type I and type II activin receptors and human erythroid differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27037

8 April 2019

Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27037

8 April 2019

Activation of signalling by the activin receptor complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27037

8 April 2019

Betaglycan binds inhibin and can mediate functional antagonism of activin signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27037

activin-activated receptor activity

1 reference

8 April 2019

Identification of a functional binding site for activin on the type I receptor ALK4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27037

transforming growth factor beta-activated receptor activity

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27037

transforming growth factor beta receptor activity, type II

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27037

type I transforming growth factor beta receptor binding

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27037

SMAD binding

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27037

activin binding

Activin and inhibin have antagonistic effects on ligand-dependent heteromerization of the type I and type II activin receptors and human erythroid differentiation

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27037

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27037

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27037

cell component

cytoplasm

1 reference

8 April 2019

Expression of activin subunits and receptors in the developing human ovary: activin A promotes germ cell survival and proliferation before primordial follicle formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27037

integral component of membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27037

1 reference

8 April 2019

inhibin-betaglycan-ActRII complex

1 reference

8 April 2019

Betaglycan binds inhibin and can mediate functional antagonism of activin signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27037

receptor complex

1 reference

5 June 2018

Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27037&geneProductId=UniProtKB:P27037

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27037

1 reference

8 April 2019

integral component of plasma membrane

1 reference

5 June 2018

Molecular cloning and binding properties of the human type II activin receptor

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27037&geneProductId=UniProtKB:P27037

cell surface

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27037

integral component of plasma membrane

receptor complex

Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27037

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27037

activin receptor complex

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27037

positive regulation of protein phosphorylation

biological process

1 reference

8 April 2019

Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27037

male gonad development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27037

ejaculation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27037

positive regulation of erythrocyte differentiation

1 reference

8 April 2019

Activin and inhibin have antagonistic effects on ligand-dependent heteromerization of the type I and type II activin receptors and human erythroid differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27037

positive regulation of bone mineralization

1 reference

8 April 2019

BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27037

phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27037

1 reference

8 April 2019

positive regulation of pathway-restricted SMAD protein phosphorylation

1 reference

8 April 2019

Bone morphogenetic protein (BMP) and activin type II receptors balance BMP9 signals mediated by activin receptor-like kinase-1 in human pulmonary artery endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27037

gastrulation with mouth forming second

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27037

penile erection

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27037

regulation of nitric-oxide synthase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27037

cellular response to BMP stimulus

2 references

8 April 2019

Bone morphogenetic protein (BMP) and activin type II receptors balance BMP9 signals mediated by activin receptor-like kinase-1 in human pulmonary artery endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27037

8 April 2019

Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27037

Sertoli cell proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27037

BMP signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27037

5 references

8 April 2019

8 April 2019

Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27037

8 April 2019

Bone morphogenetic protein (BMP) and activin type II receptors balance BMP9 signals mediated by activin receptor-like kinase-1 in human pulmonary artery endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27037

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27037

8 April 2019

BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27037

embryonic skeletal system development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27037

regulation of BMP signaling pathway

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27037

protein phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27037

1 reference

8 April 2019

determination of left/right symmetry

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27037

positive regulation of activin receptor signaling pathway

1 reference

8 April 2019

Identification of a functional binding site for activin on the type I receptor ALK4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27037

positive regulation of osteoblast differentiation

1 reference

8 April 2019

BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27037

regulation of signal transduction

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27037

spermatogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27037

mesoderm development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27037

anterior/posterior pattern specification

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27037

positive regulation of transcription by RNA polymerase II

1 reference

8 April 2019

Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27037

activin receptor signaling pathway

transforming growth factor beta receptor signaling pathway

2 references

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27037

pattern specification process

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27037

activin receptor signaling pathway

Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27037

8 April 2019

Identification of a functional binding site for activin on the type I receptor ALK4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27037

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27037

serine/threonine-protein kinase, active site

has part(s)

1 reference

http://www.ebi.ac.uk/interpro/protein/P27037

protein kinase domain

1 reference

http://www.ebi.ac.uk/interpro/protein/P27037

activin types I and II receptor domain

1 reference